| Patent Number |
Title Of Patent |
Date Issued |
| 5391810 |
Method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester |
February 21, 1995 |
| In crystallizing .alpha.-APM from a water solution or a mixed solvent solution of water and a lower alcohol in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crys |
| 5266719 |
Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester |
November 30, 1993 |
| In neutralizing an acid addition salt of .alpha.-APM in an aqueous medium, the .alpha.-APM concentration in the neutralized liquid is controlled to fall within the range of from 3 to 10 wt. % at the finish of neutralization. Then, the liquid is heated to 50.degree. to 80.degree. C. a |
| 5248806 |
Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester |
September 28, 1993 |
| An acid addition salt of .alpha.-APM is dissolved or suspended in an aqueous medium at 50.degree. C. or lower at a pH of 3 or less and a concentration of the salt of 3 wt.% or more (solution A). A liquid having a pH of 3 or more and containing or not containing .alpha.-APM is prepared |
