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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Yamakawa; Mineo
Address:
Campbell, CA
No. of patents:
34
Patents:












Patent Number Title Of Patent Date Issued
8173436 Biosensor utilizing a resonator having a functionalized surface May 8, 2012
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized sur
8158008 Device and method for particle complex handling April 17, 2012
An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a mag
8153079 Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molec April 10, 2012
Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around
8105848 Programmable electromagnetic array for molecule transport January 31, 2012
An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one o
8062841 Multiplex data collection and analysis in bioanalyte detection November 22, 2011
Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiple
7993525 Device and method for particle complex handling August 9, 2011
An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a mag
7914740 Biosensor utilizing a resonator having a functionalized surface March 29, 2011
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface
7894056 Method, structure, and apparatus for Raman spectroscopy February 22, 2011
Disclosed herein are a Raman spectroscopy structure comprising a porous material substrate, and a method of performing Raman spectroscopy of a sample disposed adjacent to the structure comprising the porous material substrate. Generally, the substrate includes one or more layers of a
7871569 Biosensor utilizing a resonator having a functionalized surface January 18, 2011
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface
7820454 Programmable electromagnetic array for molecule transport October 26, 2010
An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or mo
7705222 Controlled alignment of nano-barcodes encoding specific information for scanning probe microscop April 27, 2010
The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nano-barcodes
7606403 Model-based fusion of scanning probe microscopic images for detection and identification of mole October 20, 2009
In certain embodiments of the invention, a plurality of images of one or more subjects may be captured using different imaging techniques, such as different modalities of scanning probe microscopy. Parameters may be estimated from the plurality of images, using one or more models of know
7599056 Method, structure, and apparatus for Raman spectroscopy October 6, 2009
Disclosed herein are a Raman spectroscopy structure comprising a porous material substrate, and a method of performing Raman spectroscopy of a sample disposed adjacent to the structure comprising the porous material substrate. Generally, the substrate includes one or more layers of a
7531726 Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy May 12, 2009
The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes
7476786 Controlled alignment of nano-barcodes encoding specific information for scanning probe microscop January 13, 2009
The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nano-barcodes
7465578 Nucleic acid sequencing by Raman monitoring of uptake of precursors during molecular replication December 16, 2008
The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DNA or RNA polymerase or
7410763 Multiplex data collection and analysis in bioanalyte detection August 12, 2008
Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiple
7400395 Metal coated nanocrystalline silicon as an active surface enhanced raman spectroscopy (SERS) sub July 15, 2008
The disclosed methods and apparatus concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates. Porous silicon substrates may be formed by anodic etching in dilute hydrofluoric acid. A thin coating of a Raman active metal, such as gold or silver, may be c
7381529 Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocod June 3, 2008
A method for determining a nucleotide sequence of a nucleic acid is provided that includes contacting the nucleic acid with a series of labeled oligonucleotides for binding to the nucleic acid, wherein each labeled oligonucleotide includes a known nucleotide sequence and a molecular
7364851 Nucleic acid sequencing by Raman monitoring of uptake of precursors during molecular replication April 29, 2008
The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DNA or RNA polymerase or
7361821 Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy April 22, 2008
The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes
7302832 Use of arrays of atomic force microscope/scanning tunneling microscope tips to scan nanocodes December 4, 2007
A surface analysis device is disclosed for identifying molecules by simultaneously scanning nanocodes on a surface of a substrate. The device includes a scanning array that is capable of simultaneously scanning the nanocodes on the surface of the substrate and an analyzer that is coupled
7291466 Detecting molecular binding by monitoring feedback controlled cantilever deflections November 6, 2007
The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of t
7279134 Microfluidic devices with porous membranes for molecular sieving, metering, and separations October 9, 2007
Microfluidic devices with porous membranes for molecular sieving, metering, and separation of analyte fluids. In one aspect, a microfluidic device includes a substrate having input and output microfluidic channel sections separated by a porous membrane formed integral to the substrate.
7270952 Detecting molecular binding by monitoring feedback controlled cantilever deflections September 18, 2007
The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of t
7238477 Methods to increase nucleotide signals by Raman scattering July 3, 2007
The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids
7105301 Detecting molecular binding by monitoring feedback controlled cantilever deflections September 12, 2006
The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of t
7075642 Method, structure, and apparatus for Raman spectroscopy July 11, 2006
Disclosed herein are a Raman spectroscopy structure comprising a porous material substrate, and a method of performing Raman spectroscopy of a sample disposed adjacent to the structure comprising the porous material substrate. Generally, the substrate includes one or more layers of a
6989897 Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) sub January 24, 2006
The disclosed methods and apparatus concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates. Porous silicon substrates may be formed by anodic etching in dilute hydrofluoric acid. A thin coating of a Raman active metal, such as gold or silver, may be c
6982165 Nucleic acid sequencing by raman monitoring of molecular deconstruction January 3, 2006
The disclosed methods, apparatus and compositions are of use for nucleic acid sequencing. More particularly, the methods and apparatus concern sequencing single molecules of single stranded DNA or RNA by exposing the molecule to exonuclease activity, removing free nucleotides one at a ti
6972173 Methods to increase nucleotide signals by raman scattering December 6, 2005
The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid 13. Exonuclease 15 treatment of the labeled nuc
6970239 Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) sub November 29, 2005
The methods and apparatus 300 disclosed herein concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates 240, 340. In certain embodiments of the invention, porous silicon substrates 110, 210 may be formed by anodic etching in dilute hydrofluoric acid 150. A
6852492 Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication February 8, 2005
The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DNA or RNA polymerase or
6806543 Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molec October 19, 2004
Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around










 
 
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