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Inventor:
Wu; George G.
Address:
Basking Ridge, NJ
No. of patents:
13
Patents:












Patent Number Title Of Patent Date Issued
8273790 Exo-selective synthesis of himbacine analogs September 25, 2012
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. T
8258319 Exo- and diastereo- selective synthesis of himbacine analogs September 4, 2012
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by th
8138180 Exo-selective synthesis of himbacine analogs March 20, 2012
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. T
8076479 Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1 December 13, 2011
Disclosed is a process for the synthesis of compounds of Formula I ##STR00001## by sequentially aminating, first with a primary amine and then with a secondary amine, an intermediate compound of the structure of Formula E1, ##STR00002## wherein R.sup.1 is a linear, branched, or cy
7989653 Exo- and diastereo-selective syntheses of himbacine analogs August 2, 2011
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by th
7772276 Exo-selective synthesis of himbacine analogs August 10, 2010
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. T
7049440 Enantioselective process May 23, 2006
An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I ##STR00001## is disclosed.
6750347 Synthesis of intermediates useful in preparing tricyclic compounds June 15, 2004
A process is provided for preparing a compound having the formula ##STR1##wherein R is H or Cl.Also provided is a process for preparing a compound having the formula ##STR2##
6495689 Synthesis of intermediates useful in preparing tricyclic compounds December 17, 2002
Disclosed is a process for preparing a compound having the formula: ##STR1##wherein R, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy.
6492519 Synthesis of intermediates useful in preparing tricyclic compounds December 10, 2002
A process is provided for preparing a compound having the formula ##STR1##comprising: (a) reacting a compound having the formula ##STR2##with an isocyanate having the formula R.sup.1 NCO to produce a compound having the formula ##STR3## (b) optionally hydrolyzing the compound o
6372909 Synthesis of intermediates useful in preparing tricyclic compounds April 16, 2002
Disclosed is a process for preparing a compound having the formula: ##STR1##wherein R, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy, by(A) reacting a compound having the formula ##STR2## wherein R.sup.A, R.s
6307048 Enantioselective alkylation of tricyclic compounds October 23, 2001
Disclosed is a process for preparing a compound of the formula: ##STR1##wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4, and X.sup.5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the
6096883 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones August 1, 2000
The invention relates to intermediates of the formulae ##STR1## said intermediates being useful in a process for producing a compound of the formula ##STR2## wherein Bn is benzyl and R.sub.1, .sub.2 and R.sub.3 are as defined in the specification,










 
 
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