| Patent Number |
Title Of Patent |
Date Issued |
| 7319094 |
Increased and sustained in vivo gene expression using a nucleic acid, histone and amphipathic co |
January 15, 2008 |
| The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death. |
| 7300927 |
Method for treating or preventing Alzheimer's disease |
November 27, 2007 |
| Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an agent which reduces serum insulin levels. |
| 7291454 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention |
November 6, 2007 |
| Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential |
| 7226730 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention |
June 5, 2007 |
| Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential |
| 7138380 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention |
November 21, 2006 |
| Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential |
| 7122541 |
Methods of inhibiting metastases |
October 17, 2006 |
| The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine. |
| 7094556 |
Diagnosis and treatment of malignant neoplasms |
August 22, 2006 |
| The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting H |
| 7045616 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention |
May 16, 2006 |
| Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential |
| 6835370 |
Diagnosis and treatment of malignant neoplasms |
December 28, 2004 |
| The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to ge |
| 6815415 |
Diagnosis and treatment of malignant neoplasms |
November 9, 2004 |
| The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting H |
| 6812206 |
Diagnosis and treatment of malignant neoplasms |
November 2, 2004 |
| The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting H |
| 6797696 |
Diagnosis and treatment of malignant neoplasms |
September 28, 2004 |
| The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting H |
| 6783758 |
Diagnosis and treatment of malignant neoplasms |
August 31, 2004 |
| The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting H |
| 6770797 |
Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid |
August 3, 2004 |
| The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death. |
| 6753328 |
Methods of inhibiting metastases |
June 22, 2004 |
| The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine. |
| 6528479 |
Dominant negative mutants of IRS-1 and uses thereof |
March 4, 2003 |
| Dominant negative mutants of mammalian IRS-1 proteins and therapeutic compositions containing such mutants. Also featured are methods of using the dominant negative mutants to inhibit tyrosyl phosphorylation of endogenous IRS-1 in mammalian cells and methods of treating a mammalian m |
| 6258937 |
Hepadnavirus receptor |
July 10, 2001 |
| The invention features an hepadnavirus cellular receptor and a nucleic acid sequence that encodes the receptor. The receptor is a 170 kD surface glycoprotein, and is referred to as the p170 receptor. |
| 6071705 |
Method of detecting neurological disease or dysfunction |
June 6, 2000 |
| This invention relates to a method of detecting and diagnosing neurological disease or dysfunction using antibodies against a neurological form of Pancreatic Thread Protein (nPTP). Specifically, this invention is directed to a method of diagnosing Alzheimer's Disease, Down's Syndrome, an |
| 6025341 |
Chimeric hepatitis B/hepatitis C virus vaccine |
February 15, 2000 |
| Nucleic acid molecule that comprise an incomplete hepatitis C and hepatitis B viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C and hepatitis B viral genome i |
| 6001990 |
Antisense inhibition of hepatitis C virus |
December 14, 1999 |
| The invention features antisense oligonucleotides and methods of using these antisense oligonucleotides for inhibiting HCV RNA translation. |
| 5948888 |
Neural thread protein gene expression and detection of Alzheimer's disease |
September 7, 1999 |
| The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes |
| 5948634 |
Neural thread protein gene expression and detection of alzheimer's disease |
September 7, 1999 |
| The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes |
| 5929220 |
Hepadnavirus receptor |
July 27, 1999 |
| The invention features a purified nucleic acid that encodes a member of the hepadnavirus family of cellular receptors. The receptor is a 170 kD cell surface glycoprotein, and is referred to as the p170 receptor. The pre-S domain of the duck hepatitis B virus envelope protein binds the p1 |
| 5830670 |
Neural thread protein gene expression and detection of Alzheimer's disease |
November 3, 1998 |
| The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes |
| 5610050 |
Methods of preventing viral replication |
March 11, 1997 |
| The invention relates to methods and compositions for inhibition of viral replication. In particular, termination of replication of hepatitis B virus is achieved by introducing into a target cell an antisense oligonucleotide having a sequence substantially complementary to an mRNA wh |
| 5534406 |
Method of detecting antigenic nucleic acid-containing macromolecular entities |
July 9, 1996 |
| A method for the detection of nucleic acid-containing moieties is described which combines affinity capture of the moiety with detection and identification of the moiety's nucleic acid. |
| 5422239 |
Immunoassay utilizing monoclonal high affinity IgM antibodies |
June 6, 1995 |
| Hybridomally produced monoclonal IgM antibodies having high affinity are useful for the immunoassay and purification of vital antigens. |
| 5077192 |
Method of detecting antigenic, nucleic acid-containing macromolecular entities |
December 31, 1991 |
| A method for the detection of nucleic acid-containing moieties is described which combines affinity capture of the moiety with detection and identification of the moiety's nucleic acid. |
| 5011771 |
Multiepitopic immunometric assay |
April 30, 1991 |
| The invention relates to an immunometric assay for a multivalent antigen in a sample which comprises forming a complex of the antigen together with multiple immobilized monoclonal antibodies against different epitopes of the antigen and with a detectably labeled soluble monoclonal antibo |
| 4973669 |
Monoclonal IgM antibody with specificity against hepatitis B surface antigen |
November 27, 1990 |
| The monoclonal antibodies are specific for a determinant found on hepatitis B surface antigen, and show high affinity for this determinant. Hybridomally produced monoclonal IgM antibodies having high affinity are useful for the immunoassay and purification of viral antigens. |
| 4933275 |
Method for the detection of a polypeptide subunit in the presence of a quaternary protein contai |
June 12, 1990 |
| A method for the determination of a free protein subunit of a quaternary protein in a sample, which comprises:(a) contacting a sample with a first immunological binding partner which is or will be bound to a carrier, wherein the first immunological binding partner binds epitopic determin |
| 4879219 |
Immunoassay utilizing monoclonal high affinity IgM antibodies |
November 7, 1989 |
| Hybridomally produced monoclonal IgM antibodies having high affinity are useful for the immunoassay and purification of viral antigens. |
| 4837167 |
Immunoassay for multi-determinant antigens using high-affinity |
June 6, 1989 |
| A simultaneous sandwich immunoassay employing high-affinity monoclonal antibodies is disclosed. This simultaneous sandwich assembly has surprising sensitivity compared to forward and reverse sandwich assays for the detection of multi-determinant antigens such as hepatitis B surface a |
| 4804626 |
Immunometric assay for the detection of human chorionic gonadotropin |
February 14, 1989 |
| A highly sensitive and specific monoclonal-immuno-radiometric assay (M-IRMA) for hCG, using monoclonal antibodies (Mabs) directed against a 37-amino acid synthetic polypeptide analogous to the carboxyl terminus (CTP) of beta-hCG. Accordingly, in one embodiment, a method is described |
| 4714613 |
Method of suppressing cell growth by immunotherapy |
December 22, 1987 |
| A selective method of suppressing the growth of cells which express a viral antigen on the surface thereof, which comprises administering to the cells a growth suppressing amount of a monoclonal antibody against said viral antigen, especially a method of suppressing the growth of hepatoc |
| 4491632 |
Process for producing antibodies to hepatitis virus and cell lines therefor |
January 1, 1985 |
| Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce m |
| 4271145 |
Process for producing antibodies to hepatitis virus and cell lines therefor |
June 2, 1981 |
| Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce m |
