| Patent Number |
Title Of Patent |
Date Issued |
| 6833408 |
Methods for tissue repair using adhesive materials |
December 21, 2004 |
| A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inte |
| 6653450 |
Mutated recombinant collagens |
November 25, 2003 |
| The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptides by one or two non-natural site-specific proteolytic agent (e.g., protease) recognition sites. A wide variety of propeptides and site-specific proteolytic agent |
| 6624245 |
Rapid-gelling biocompatible polymer composition and associated methods of preparation and use |
September 23, 2003 |
| A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i.e., at a selected site within a patient's body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein m.gtoreq.2 and a biocompatible |
| 6495127 |
Compositions and systems for forming high strength medical sealants, and associated methods of p |
December 17, 2002 |
| The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form |
| 6458889 |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparat |
October 1, 2002 |
| Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked biomaterials. The compositions contain at least three biocompatible, nonimmunogenic components having reactive functional groups thereon, with the functional gr |
| 6413737 |
Ecarin prothrombin protease and methods |
July 2, 2002 |
| New forms of ecarin, a procoagulant protein from Echis carinatus venom, are described, as are polynucleotides encoding the new proteins, methods for production of the new proteins, and methods for activation of prothrombin using the new proteins. The new ecarins comprise a serine at posi |
| 6312725 |
Rapid gelling biocompatible polymer composition |
November 6, 2001 |
| This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired |
| 6280727 |
Compositions containing thrombin and microfibrillar collagen and methods for preparation and use |
August 28, 2001 |
| The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present inve |
| 6096309 |
Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparat |
August 1, 2000 |
| The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present inve |
| 6066325 |
Fragmented polymeric compositions and methods for their use |
May 23, 2000 |
| Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an |
| 6063061 |
Fragmented polymeric compositions and methods for their use |
May 16, 2000 |
| Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice at the target site. Alternativel |
| 5931165 |
Films having improved characteristics and methods for their preparation and use |
August 3, 1999 |
| Gelatin film compositions are useful for immobilization over tissue, usually by the application of energy to the films. Exemplary films comprise cross-linked and non-cross-linked granular and non-granular gelatin sheets, typically including a plasticizer. The gelatin films are dry, t |
| 5749895 |
Method for bonding or fusion of biological tissue and material |
May 12, 1998 |
| Biological materials are joined, repaired or fused by heating the material in proximity to a mechanical support. Preferably, the mechanical support comprises a patch or bridge structure. In the most preferred embodiment, the patch is formed from collagen having a thickness from between 2 |
| 5550188 |
Polymer conjugates ophthalmic devices comprising collagen-polymer conjugates |
August 27, 1996 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5543441 |
Implants coated with collagen-polymer conjugates |
August 6, 1996 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5523348 |
Method of preparing collagen-polymer conjugates |
June 4, 1996 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5446091 |
Collagen-polymer conjugates containing an ether linkage |
August 29, 1995 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5413791 |
Collagen-polymer conjugates |
May 9, 1995 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5376375 |
Method of augmenting tissue using collagen-polymer conjugates |
December 27, 1994 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5352715 |
Injectable ceramic compositions and methods for their preparation and use |
October 4, 1994 |
| Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 .mu.m to 250 .mu.m. Optionally, the compositions may further comprise collagen, where the r |
| 5328955 |
Collagen-polymer conjugates |
July 12, 1994 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5324775 |
Biologically inert, biocompatible-polymer conjugates |
June 28, 1994 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthet |
| 5306500 |
Method of augmenting tissue with collagen-polymer conjugates |
April 26, 1994 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5304595 |
Collagen-polymer conjugates |
April 19, 1994 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5264214 |
Composition for bone repair |
November 23, 1993 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5204382 |
Injectable ceramic compositions and methods for their preparation and use |
April 20, 1993 |
| Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 .mu.m to 250 .mu.m. Optionally, the compositions may further comprise collagen, where the r |
| 5162430 |
Collagen-polymer conjugates |
November 10, 1992 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 4803075 |
Injectable implant composition having improved intrudability |
February 7, 1989 |
| Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue. |
| 4789663 |
Methods of bone repair using collagen |
December 6, 1988 |
| A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen |
| 4582640 |
Injectable cross-linked collagen implant material |
April 15, 1986 |
| Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in |
| 4424208 |
Collagen implant material and method for augmenting soft tissue |
January 3, 1984 |
| An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this material have improved persistence rela |
