| Patent Number |
Title Of Patent |
Date Issued |
| 8216852 |
Channel cross-section geometry to manipulate dispersion rates |
July 10, 2012 |
| The present invention provides novel methods for controlling/manipulating materials flowing in a fluidic device. In particular, the methods of the invention create and utilize differences between dispersion rates and/or average velocity of materials in order to manipulate the materials. |
| 7754150 |
Microfluidic analytic detection assays, devices, and integrated systems |
July 13, 2010 |
| Methods of detecting a component of interest, such as a protein, in a microfluidic system are provided. The methods include the use of a component-binding moiety specific to the component of interest, such as an antibody, to detect the component of interest. Also included are microfl |
| 6989128 |
Apparatus for continuous liquid flow in microscale channels using wicking |
January 24, 2006 |
| Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an upstream region of the device. Such methods include electrokinetic injection or withdrawal of |
| 6979553 |
Use of Nernstein voltage sensitive dyes in measuring transmembrane voltage |
December 27, 2005 |
| Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for transmembrane potential |
| 6759191 |
Use of nernstein voltage sensitive dyes in measuring transmembrane voltage |
July 6, 2004 |
| Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for transmembrane potential |
| 6649358 |
Microscale assays and microfluidic devices for transporter, gradient induced, and binding activi |
November 18, 2003 |
| Methods of monitoring transporter activity, gradient induced activity, and binding activity in microscale systems, as well as corresponding microscale devices, systems and kits are provided. |
| 6613581 |
Microfluidic analytic detection assays, devices, and integrated systems |
September 2, 2003 |
| Methods of detecting a component of interest, such as a protein, in a microfluidic system are provided. The methods include the use of a component-binding moiety specific to the component of interest, such as an antibody, to detect the component of interest. Also included are microfl |
| 6592821 |
Focusing of microparticles in microfluidic systems |
July 15, 2003 |
| Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle |
| 6537771 |
Use of nernstein voltage sensitive dyes in measuring transmembrane voltage |
March 25, 2003 |
| Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for transmembrane potential |
| 6529835 |
High throughput methods, systems and apparatus for performing cell based screening assays |
March 4, 2003 |
| Methods for determining a function of cells, which comprises a suspension of cells flowing along a first fluid channel. The cells have a first detectable property associated therewith, and wherein the cells produce a second detectable property upon activation of the function of the cells |
| 6506609 |
Focusing of microparticles in microfluidic systems |
January 14, 2003 |
| Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, |
| 6416642 |
Method and apparatus for continuous liquid flow in microscale channels using pressure injection, |
July 9, 2002 |
| Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an upstream region of the device. Such methods include electrokinetic injection or withdrawal of |
| 6379884 |
Methods and systems for monitoring intracellular binding reactions |
April 30, 2002 |
| Intracellular binding reactions, and particularly DNA/DNA binding protein reactions are detected in situ, using intracellular fluorescence polarization detection. The methods comprise providing a biological cell having at least a first component of a binding reaction disposed therein. |
| 5632982 |
Cytotoxic enhancement of TNF with copper |
May 27, 1997 |
| Copper chelates serve as cytotoxic agents in conjunction with a surface membrane protein receptor internalizing agent, particularly TNF, which has independent cytotoxic activity, for use against target cells. By employing concentrations of the two agents, where the agents have substantia |
