| Patent Number |
Title Of Patent |
Date Issued |
| 6852694 |
Stabilized insulin formulations |
February 8, 2005 |
| The present invention is directed to stabilized insulin composition comprising a mixture of insulin species such as insulin and an insulin analog. As disclosed herein, insulin compositions comprising a mixture of insulin and insulin analog species form heterodimeric complexes having a |
| 6804544 |
Detection of biological molecules using chemical amplification and optical sensors |
October 12, 2004 |
| Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and b |
| 6784274 |
Hydrophilic, swellable coatings for biosensors |
August 31, 2004 |
| Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of wa |
| 6766183 |
Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers |
July 20, 2004 |
| Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. Embodiments of these biosensor molecules exhibit fluorescence emission at wavelengths greater than about 650 nm. Typical bi |
| 6750311 |
Detection of biological molecules using boronate-based chemical amplification and optical sensor |
June 15, 2004 |
| Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and b |
| 6734162 |
Mixed buffer system for stabilizing polypeptide formulations |
May 11, 2004 |
| The present invention is a pharmaceutical composition for polypeptide which are not stably soluble. A preferred polypeptide is monomeric insulin and a preferred formulation consists of a TRIS-phosphate combination buffer, zinc; a phenolic preservative and an isotonicity agent such as gly |
| 6462162 |
Hydrophilic, swellable coatings for biosensors |
October 8, 2002 |
| Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of wa |
| 6443942 |
Medication device with protein stabilizing surface coating |
September 3, 2002 |
| The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate |
| 6319540 |
Detection of biological molecules using chemical amplification and optical sensors |
November 20, 2001 |
| Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and b |
| 6011984 |
Detection of biological molecules using chemical amplification and optical sensors |
January 4, 2000 |
| Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and b |
| 6002954 |
Detection of biological molecules using boronate-based chemical amplification and optical sensor |
December 14, 1999 |
| Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and b |
| 5786439 |
Hydrophilic, swellable coatings for biosensors |
July 28, 1998 |
| Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of wa |
| 5777060 |
Silicon-containing biocompatible membranes |
July 7, 1998 |
| Biocompatible membranes for use with biosensors are provided. The membranes are polymers which can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer, (c) a siloxane polymer having functional groups at the chain termini, and optionally, (d) a chain extender. |
