| Patent Number |
Title Of Patent |
Date Issued |
| 6326495 |
Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-a |
December 4, 2001 |
| The invention concerns a method of preparing an 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-a s-indacene compound of the formula: ##STR1##and pharmaceutically acceptable salt forms thereof, where R.sup.1 is hydrogen; alkyl; alkoxy; alkoxyalkyl; alkenyl; cy |
| 6124457 |
Process and intermediates for a .beta..sub.3 -adrenergic receptor agonist |
September 26, 2000 |
| The instant invention relates to intermediates of Formula II, ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to processes for preparing compounds of Formula III, ##S |
| 6090942 |
Process and intermediates for a .beta..sub.3 -adrenergic receptor agonist |
July 18, 2000 |
| The instant invention relates to intermediates of Formula II, ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to processes for preparing compounds of Formula III, ##S |
| 6022984 |
Efficient synthesis of furan sulfonamide compounds useful in the synthesis of new IL-1 inhibitor |
February 8, 2000 |
| An efficent synthesis of furan sulfonamide compounds of formula ##STR1## comprising reacting a compound of formula 11 with a Grignard reagent in a reaction inert solvent, wherein R' is (C.sub.1 -C.sub.6)alkyl. The compound of formula II is prepared by reacting a compound of formula I |
| 5977355 |
Processes and intermediates for preparing 3-amino-benzo(b)azepinones |
November 2, 1999 |
| A process for the preparation of CCK antagonists of the formula ##STR1## wherein X, Y.sup.1 and Y.sup.2 are defined above and to novel intermediates used in the process. |
| 5637713 |
Process for preparing trans-piperidine-2,5-dicarboxylates |
June 10, 1997 |
| Process for the preparation of a dialkyl trans-piperidine-2,5-dicarboxylate from a corresponding dialkyl cis-piperidine-2,5-dicarboxylate via a trans-substituted pyridine derivative of the formula ##STR1## wherein R is a (C.sub.1 -C.sub.3)alkyl group. |
| 5489688 |
Process for preparing trans-piperidine-2,5-dicarboxylates |
February 6, 1996 |
| Process for the preparation of a dialkyl trans-piperidine-2,5-dicarboxylate from a corresponding dialkyl cis-piperidine-2,5-dicarboxylate via a trans-substituted pyridine derivative of the formula ##STR1## wherein R is a (C.sub.1 -C.sub.3)alkyl group. |
| 5455350 |
Process and intermediate for certain bis-aza-bicyclic anxiolytic agents |
October 3, 1995 |
| (C.sub.1 -C.sub.3)Alkyl-4,6,7,8,9,9a-hexahydro-2H,3H-pyrido[1,2-a]pyrazin-1-one-7-c arboxylate esters, important precursors to certain bis-aza-bicyclic anxiolytics, can be prepared from di(C.sub.1 -C.sub.3)alkyl cis-piperidine-2,5-dicarboxylate starting material by a new process via a |
| 5359068 |
Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl |
October 25, 1994 |
| A process for preparing the compound of the formula ##STR1## which comprises treating a compound of the formula ##STR2## wherein R.sup.2 is hydrogen, CN or CO.sub.2 R.sup.1 and R.sup.1 is hydrogen or (C.sub.1 -C.sub.6)alkyl with a reducing agent with the proviso that when R.s |
| 5326874 |
Process for preparing trans-piperidine-2,5-dicarboxylates |
July 5, 1994 |
| Process for the preparation of a dialkyl trans-piperidine-2,5-dicarboxylate from a corresponding dialkyl cis-piperidine-2,5-dicarboxylate via a transsubstituted pyridine derivative of the formula ##STR1## wherein R is a (C.sub.1 -C.sub.3)alkyl group. |
| 5206367 |
Preparation of optically active spiro-hydantoins |
April 27, 1993 |
| This invention relates to the preparation of preparing optically-active asymmetric spiro-hydantoin compounds, which are known to be of value in the medical control of certain chronic diabetic complications arising from diabetes mellitus. This invention also includes within its scope cert |
| 5185449 |
Process and intermediate for certain bis-aza-bicyclic anxiolytic agents |
February 9, 1993 |
| (C.sub.1 -C.sub.3)Alkyl-4,6,7,8,9,9a-hexahydro-2H,3H-pyrido-[1,2-a]pyrazin-1-one-7- carboxylate esters, important precursors to certain bis-aza-bicyclic anxiolytics, can be prepared from di(C.sub.1 -C.sub.3)alkyl cis-piperidine-2,5-dicarboxylate starting material by a new process via |
| 5149821 |
Process and intermediates for optically active 3-formyltetrahydropyrans |
September 22, 1992 |
| Process and intermediate useful in the preparation of optically active 3-formyltetrahydropyrans from racemic 3-formyltetrahydropyran. |
| 5010185 |
Processes for tigogenin beta-cellobioside |
April 23, 1991 |
| Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials. |
| 4935442 |
Tetrahydrofuran-containing macrocyclic polyether carboxylic acids |
June 19, 1990 |
| A series of tetrahydrofuran-containing, macrocyclic polyether compounds. The macrocycles have a 21-membered ring, incorporating six oxygen atoms, and they have a carboxy group (or a salt thereof) directed towards the interior of the ring. Administration of the compounds of the invention |
| 4876367 |
Macrocyclic polyether carboxylic acids |
October 24, 1989 |
| A series of novel, macrocyclic polyether compounds. The macrocycles have a 21-membered ring, containing six oxygen atoms, and they have a carboxy group (or a salt thereof) directed towards the interior of the ring. Administration of the compounds of the invention to ruminant animals (e.g |
| 4874877 |
Process for optically active 3-(methane-sulfonyloxy)thiolane and analogs |
October 17, 1989 |
| Intermediates and a stepwise process for the conversion of D-methionine or certain of its derivatives to optically active compounds of the formula ##STR1## wherein R is (C.sub.1 -C.sub.3) alkyl, phenyl or tolyl. The latter compounds are in turn useful as an intermediate in the prepar |
| 4841079 |
Process for the production of asymmetric hydantoins |
June 20, 1989 |
| An improved process for preparing (4S)-6-fluorospiro-[chroman-4,4'-imidazolidine]-2',5'-dione (sorbinil) or its (2R)-methyl derivative (2-methylsorbinil) is disclosed herein, starting from p-fluorophenol in each instance. The final products obtained have known pharmaceutical value as |
| 4777270 |
Macrocyclic polyether carboxylic acids |
October 11, 1988 |
| A series of novel, macrocyclic polyether compounds. The macrocycles have a 21-membered ring, containing six oxygen atoms, and they have a carboxy group (or a salt thereof) directed towards the interior of the ring. Administration of the compounds of the invention to ruminant animals (e.g |
| 4716113 |
Process for the production of an (S)-methyl or (S)-ethyl 4-amino-6-fluorochroman-4-carboxylate |
December 29, 1987 |
| An improved process for preparing (4S)-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione (sorbinil) or its (2R)-methyl derivative (2-methylsorbinil) is disclosed herein, starting from p-fluorophenol in each instance. The final products obtained have known pharmaceutical value a |
| 4663474 |
Synthetic intermediates for a chiral 3-(substituted-phenyl)-4-(3-hydroxypropyl) cyclohexanol |
May 5, 1987 |
| Racemic endo- and exo-1-methoxybicyclo[2.2.2]oct-5-ene-2-carboxylic acids are starting materials for a novel and efficient synthesis of chiral 3R-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4R-(3-hydroxypropyl)-1R-cycloh exanol, a compound having valuable central nervous system (CNS) activit |
| 4585888 |
Synthetic method for a chiral 3-(substituted-phenyl)-4-(3-hydroxypropyl)cyclohexanol |
April 29, 1986 |
| Racemic endo- and exo-1-methoxybicyclo[2.2.2]oct-5-ene-2-carboxylic acids are starting materials for a novel and efficient synthesis of chiral 3R-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4R-(3-hydroxypropyl)-1R-cycloh exanol, a compound having valuable central nervous system (CNS) activit |
