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Inventor:
Underiner; Gail E.
Address:
Brier, WA
No. of patents:
20
Patents:












Patent Number Title Of Patent Date Issued
6133274 Hydroxyl-containing bicyclic compounds October 17, 2000
Disclosed are therapeutic compounds having the formula:including resolved enantiomers, diastereomers, hydrates, salts, solvates and mixtures thereof. j is an integer from one to three, the core moiety is either non-cyclic or comprises at least one five- to seven-membered ring structure,
6103730 Amine substituted compounds August 15, 2000
Compounds and pharmaceutical compositions, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, have the formula:In these compounds, j is an integer from one to three; the core moiety is a cyclic core, the cyclic core being non-cyclic or at
6100271 Therapeutic compounds containing xanthinyl August 8, 2000
Therapeutic compounds with at least one carboxylic acid, ester or amide-substituted side chain have the formula:wherein j is an integer from one to three. The core moiety is non-cyclic or cyclic (carbocyclic or heterocyclic). R may be selected from among hydrogen, halogen, hydroxyl, amin
6043250 Methods for using therapeutic compounds containing xanthinyl March 28, 2000
Therapeutic compounds with at least one carboxylic acid, ester or amide-substituted side chain have the formula:wherein j is an integer from one to three. The core moiety is non-cyclic or cyclic (carbocyclic or heterocyclic). R may be selected from among hydrogen, halogen, hydroxyl, amin
5889011 Substituted amino alkyl compounds March 30, 1999
Compounds and pharmaceutical compositions thereof comprise the formula:including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, wherein J is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-m
5837703 Amino-alcohol substituted cyclic compounds November 17, 1998
Therapeutic compounds have the formula:j being an integer from one to three, the core moiety comprising a core moiety, the core moiety being a heterocycle having one ring or two-fused rings, each ring having five or six ring atoms, A being a carbon atom of the core moiety and attached to
5824677 Substituted amino alcohol compounds October 20, 1998
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl
5817662 Substituted amino alkyl compounds October 6, 1998
Compounds and pharmaceutical compositions thereof comprise the formula:including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, wherein J is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-m
5807862 Therapeutic compounds containing pyrimidinyl moieties September 15, 1998
Therapeutic compounds with at least one carboxylic acid, ester or amide-substituted side chain have the formula:wherein j is an integer from one to three. The core moiety is non-cyclic or cyclic (carbocyclic or heterocyclic). R may be selected from among hydrogen, halogen, hydroxyl, amin
5807861 Amine substituted xanthinyl compounds September 15, 1998
A method for treating a disease caused by an undesirable cell response mediated by a proliferative intracellular signaling pathway is provided wherein an effective amount of a compound is administered. The compound, resolved enantiomers, diastereomers, hydrates, salts, solvates and m
5804584 Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one t September 8, 1998
Disclosed are therapeutic compounds having the formula:including resolved enantiomers, diastereomers, hydrates, salts, solvates and mixtures thereof. j is an integer from one to three, the core moiety is either non-cyclic or comprises at least one five- to seven-membered ring structure,
5801182 Amine substituted compounds September 1, 1998
Compounds and pharmaceutical compositions, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, have the formula:In these compounds, j is an integer from one to three; the core moiety is a cyclic core, the cyclic core being non-cyclic or at
5801181 Amino alcohol substituted cyclic compounds September 1, 1998
Therapeutic compounds have the formula:J being an integer from one to three, the core moiety having at least one, five- to seven-membered ring and X being a racemic mixture, R or S enantiomer, slovate, hydrate, or salt of: ##STR1## *C is a chiral carbon atom, n is an integer from one
5780476 Hydroxyl-containing xanthine compounds July 14, 1998
Disclosed are therapeutic compounds having the formula:including resolved enantiomers, diastereomers, hydrates, salts, solvates and mixtures thereof. j is an integer from one to three, the core moiety is either non-cyclic or comprises at least one five- to seven-membered ring structure,
5777117 Method for preparing substituted amino alcohol compounds July 7, 1998
Disclosed is a process for preparing compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight
5756511 Method for treating symptoms of a neurodegenerative condition May 26, 1998
A method for treating symptoms of Alzheimer's Disease by administering an effective amount of a compound, racemate, isolated R or S enantionmer, solvate, hydrate or salt having the formula:In the above formula, the terminal heterocyclic moiety is a 3,7-dimethylxanthinyl, 3-methylxanthiny
5750575 Substituted amino alcohol compounds May 12, 1998
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl
5641783 Substituted amino alcohol compounds June 24, 1997
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl
5629423 Asymmetric synthesis of chiral secondary alcohols May 13, 1997
A process for synthesizing enantiomerically pure chiral secondary alcohol compounds linked to a heterocyclic core moiety, using a natural chiral molecule starting material. The inventive process is particularly useful for bulk manufacturing of chiral secondary alcohol compounds.
5470878 Cell signaling inhibitors November 28, 1995
Therapeutic compounds have the formula:j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate, hydrate, or salt of: ##STR1## *C is a chiral carbon atom, n is an integer from one to four (preferably from one to three)










 
 
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