| Patent Number |
Title Of Patent |
Date Issued |
| 7632645 |
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage |
December 15, 2009 |
| The present invention relates to agents and methods for growth-factor receptor activation by modulating the G-protein mediated signal transduction pathway. |
| 7074589 |
Nucleic acids encoding BDP-1 |
July 11, 2006 |
| Nucleic acid molecules encoding full length PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides, portions of such nucleic acid molecules, nucleic acid vectors containing such nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purif |
| 6913894 |
Antibodies directed against signal regulator proteins |
July 5, 2005 |
| Monoclonal antibodies which bind specifically to the extracellular domain of the SIRP cell surface glycoproteins, and which, in some cases, block the interaction of SIRP with the surface molecule CD47, are described. |
| 6897029 |
MCK-10 a novel receptor tyrosine kinase |
May 24, 2005 |
| The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of inhibiting MCK-10 activity. The invention relates to differentially spliced isoforms of MCK- |
| 6872699 |
Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotid |
March 29, 2005 |
| The present invention relates to the use of ligands for the FLK-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cells and the identificati |
| 6797513 |
Nucleic acid encoding CLK2 protein kinases |
September 28, 2004 |
| The present invention relates to nucleic acid molecules encoding mCLK2, mCLK3, and mCLK4 polypeptides, nucleic acid molecules-encoding portions of their amino acid sequences, nucleic acid vectors harboring such nucleic acid molecules, cells containing such nucleic acid vectors, purified |
| 6541615 |
SIRP proteins and uses thereof |
April 1, 2003 |
| The present invention features isolated, purified, or enriched nucleic acid encoding a SIRP polypeptide and isolated, purified, or enriched SIRP polypeptide and uses thereof. |
| 6331555 |
Treatment of platelet derived growth factor related disorders such as cancers |
December 18, 2001 |
| The present invention concerns compounds which can inhibit platelet derived growth factor receptor (PDGF-R) activity, preferably such compounds also inhibit the activity other members of the PDGF-R super family and are selective for members of the PDGF-R super family. The PDGF-R super fa |
| 6177401 |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
January 23, 2001 |
| The present invention relates to the use of proteins, peptides and organic molecules capable of modulating Flk-1 receptor signal transduction in order to inhibit or promote angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1 tyrosine kinase |
| 6051397 |
DNA encoding MCK-10, a novel receptor tyrosine kinase |
April 18, 2000 |
| The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of inhibiting MCK-10 activity. The invention relates to differentially spliced isoforms of MCK- |
| 6004791 |
Protein tyrosine phosphatase PTP20 and related products and methods |
December 21, 1999 |
| The present invention relates to a novel polypeptide, PTP20, and to nucleic acid molecules encoding the polypeptide. The invention also relates to nucleic acid molecules encoding portions of the phosphatase, nucleic acid vectors containing PTP20 related nucleic acid molecules, recombinan |
| 5955592 |
Nucleic acid encoding novel protein phosphotyrosine phosphatase PTP-D1 |
September 21, 1999 |
| The present invention relates to PTP-D1, a member of the novel PTP-D subfamily of protein tyrosine phosphatases. The present invention is directed to isolated PTP-D1 protein, nucleic acid constructs encoding for PTP-D1, cells containing the nucleic acid constructs, and methods for pr |
| 5945523 |
Diagnosis and treatment of TKA-1 related disorders |
August 31, 1999 |
| The present invention relates to TKA-1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for trea |
| 5863755 |
Nucleic acid encoding novel receptor-type phosphotyrosine phosphatase-.kappa. |
January 26, 1999 |
| A novel receptor-type protein tyrosine phosphatase-.kappa. (RPTP.kappa.) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. The RPTP.kappa. protein or glycoprotein may be produced by recombinant means. Antibodies to the protein, metho |
| 5861266 |
Treatment of diabetes mellitus and insulin receptor signal transduction |
January 19, 1999 |
| The present invention relates to novel modalities of treatment of diabetes, and other diseases caused by dysfunctional signal transduction by insulin receptor type tyrosine kinases (IR-PTK). Applicants discovered that IR-PTK activity may be modified by modulating the activity of a tyrosi |
| 5856162 |
Receptor-type phosphotyrosine phosphatase-.kappa. |
January 5, 1999 |
| A novel receptor-type protein tyrosine phosphatase-.kappa. (RPTP.kappa.) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. The RPTP.kappa. protein or glycoprotein may be produced by recombinant means. Antibodies to the protein, metho |
| 5856111 |
Methods for identifying modulators of insulin receptor phosphorylation |
January 5, 1999 |
| The present invention relates to cell lines useful for the screening and identification of compounds that by modulating phosphotyrosine phosphatase activity, modulate insulin receptor type tyrosine kinase mediated signal transduction. Genetically engineered cells expressing IR in culture |
| 5851999 |
FLK-1 is a receptor for vascular endothelial growth factor |
December 22, 1998 |
| The present invention relates to the use of ligands for the FLK-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cells and the identificati |
| 5831009 |
Protein phosphotyrosine phosphatases PTP-D1 |
November 3, 1998 |
| The present invention relates to PTP-D1, a member of the novel PTP-D subfamily of protein tyrosine phosphatases. The present invention is directed to isolated PTP-D1 protein, nucleic acid constructs encoding for PTP-D1, cells containing the nucleic acid constructs, and methods for pr |
| 5719022 |
Process for diagnosing non-insulin-dependant diabetes mellitus |
February 17, 1998 |
| To diagnose non-insulin dependent diabetes mellitus or a genetically conditioned disposition thereto, examinations are made of tissue cells, especially skeletal muscle cells, from the person concerned for the presence of the human insulin receptor type B (HIR-B). This examination is |
| 5700823 |
Treatment of platelet derived growth factor related disorders such as cancers |
December 23, 1997 |
| Method for treating a patient inflicted with a cell proliferation disorder, such as a cancer, characterized by inappropriate PDGF-R activity. The method involves the step of administering to the patient a therapeutically effective amount of a composition described in application. |
| 5677144 |
Recombinant DNA encoding CCK 2, a receptor tyrosine kinase |
October 14, 1997 |
| A recombinant nucleic acid molecule encoding a receptor tyrosine kinase identified herein as CCK-2, and specific functional fragments thereof are provided. Also, provided is a nucleic acid encoding a chimeric protein comprising all or a specific part of CCK-2, as well as a process of |
| 5459036 |
Extracellular signal-regulated kinase, sequences, and methods of production and use |
October 17, 1995 |
| The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid |
