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Inventor:
Ts'o; Paul O. P.
Address:
Lutherville, MD
No. of patents:
8
Patents:




Patent Number Title Of Patent Date Issued
6080726 Anti-viral and immuno stimulator polynucleotide duplex and use thereof June 27, 2000
A method of treating HSV-2 infection which comprises administering to a host subject to said infection an effective amount of a polynucleotide of the formula polyrI.polyr(C.sub.12 U) where n is an integer from 4 to 29. The polynucleotide is advantageously administered intranasally.
5912339 Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nu June 15, 1999
A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucle
4757055 Method for selectively controlling unwanted expression or function of foreign nucleic acids in a July 12, 1988
A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for said nucleic acid and binding the said nucleic acid with an appropriately prepar
4591614 Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates May 27, 1986
Oligonucleoside-3'-alkyl or aryl phosphonates are prepared by condensing (i) a 5'-protected nucleoside 3'-alkyl or aryl phosphonic imidazolide with (ii) a nucleoside or oligomer which is attached through its 3'-position to a polymer support. The process is advantageously carried out in t
4587044 Linkage of proteins to nucleic acids May 6, 1986
A nucleic acid-protein conjugate which is specific with respect to a selected living cell is prepared by linking said nucleic acid to a protein specific to said living cell.
4511713 Process for selectively controlling unwanted expression or function of foreign nucleic acids in April 16, 1985
A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for the nucleic acid and binding the nucleic acid with an appropriately prepared nonioni
4507433 Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates March 26, 1985
Process for synthesizing deoxyribonucleoside methylphosphonates on polystyrene polymer supports which involves condensing 5'-dimethoxytrityldeoxynucleoside 3'-methylphosphonates. The oligomers are removed from the support and the base protecting groups hydrolyzed by treatment with et
4469863 Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof September 4, 1984
Oligonucleoside alkyl-- or aryl phosphonates are nonionic analogues of nucleic acid which possess unique physical and biological properties. These properties enable the analogues to enter living cells intact and to bind with specifically selected nucleic acids within the cell. As a r


 
 
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