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Inventor:
Temple, Jr.; Davis L.
Address:
Evansville, IN
No. of patents:
28
Patents:












Patent Number Title Of Patent Date Issued
4895846 Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpipera January 23, 1990
A series of 1,4-dihydropyridin-3,5-yl dicarboxylic acid amides and esters incorporating an arylpiperazinylalkyl moiety have been prepared possessing the general formula ##STR1## wherein R.sup.4 is cycloalkyl, aryl or hetaryl, generally with electron-withdrawing substituents; R.su
4755512 Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpipera July 5, 1988
A series of 1,4-dihydropyridin-3,5-yl dicarboxylic acid amides and esters incorporating an arylpiperazinylalkyl moiety have been prepared possessing the general formula ##STR1## wherein R.sup.4 is cycloalkyl, aryl or hetaryl, generally with electronwithdrawing substituents; R.sup
4642345 6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones February 10, 1987
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophyl
4581357 Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound April 8, 1986
8-[4-[4-(5-Fluoro-pyrimidin-2-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decan e-7,9-dione and its pharmaceutically acceptable salts demonstrate antipsychotic activity.
4575555 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative March 11, 1986
Phenoxyalkyl substituted-1,2,4-triazolones having antidepressant properties typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one are disclosed.
4540581 Topical nonsteroidal anti-inflammatory compositions and uses September 10, 1985
New compositions using particular .beta..sub.2 agonists and vehicle materials have been prepared and are useful for producing a topical anti-inflammatory effect in mammals. The selected .beta..sub.2 agonists have previously not been known to exhibit topical antiinflammatory activity.
4491587 Tetrazole derivatives January 1, 1985
6-(1H-Tetrazol-5-yl)thiazolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo- pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on
4489078 Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators December 18, 1984
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophyl
4487773 1,2,4-Triazol-3-one antidepressants December 11, 1984
Phenoxyalkyl substituted-1,2,4-triazolones having anti-depressant properties typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one are disclosed.
4456756 Spirothiazolidinyl piperazine derivatives June 26, 1984
Piperazinyl derivatives containing a spiro-2,4-thiazolidinedione heterocyclic component with relatively selective psychotropic properties are disclosed. The compound 2-[4-[4-(7,9-dioxo-6-thia-8-azaspiro[4.4]nonan-8-yl)butyl]-1-piperazinyl]p yridine-3-carbonitrile which has selective a
4452799 Benzisothiazole and benzisoxazole piperazine derivatives June 5, 1984
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is benzisothiazol-3-yl or benzisoxazol-3-yl and the other is alkylene attached to heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione and spirocyclopentylthiazolidinedione
4423049 2-[4-[(4,4 -Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines December 27, 1983
1-[4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]piperazines with 2-pyrimidyl substituents in the 4- position have been synthesized and demonstrate useful anxiolytic properties. The compound 4,4-dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedi one, which has selec
4419358 Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an December 6, 1983
This invention concerns an isethionic acid addition salt of the non-adrenergic bronchodilating agent 9-cyclohexyl-2-propoxy-9H-purine-6-amine. The salt is comprised of a 2:1 molecular ratio of the isethionic acid to the adenine base. The salt of the invention is characterized in havi
4411901 Benzisothiazole and benzisoxazole piperazine derivatives October 25, 1983
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is benzisothiazol-3-yl or benzisoxazol-3-yl and the other is alkylene attached to heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione and spirocyclopentylthiazolidinedione
4404380 Triazolopyrimidines September 13, 1983
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophyl
4386091 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants May 31, 1983
Phenoxyalkyl substituted-1,2,4-triazolones having antidepressant properties typified by 4-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-2-(2-ph enoxyethyl)-3H-1,2,4-triazol-3-one are disclosed.
4367335 Thiazolidinylalkylene piperazine derivatives January 4, 1983
Piperazinyl derivatives containing a 3-alkylene-2,4-thiazolidinedione heterocyclic component with relatively selective psychotropic properties are disclosed. The compound 3-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,4-thiazolidinedione which has selective anxiolytic activity consti
4366156 Antiallergic methods using diazaheterocyclopurines December 28, 1982
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophyl
4361565 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines November 30, 1982
1-[4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]piperazines with 2-2-(3-cyano)pyridyl substituents in the 4- position have been synthesized and demonstrate useful psychotropic properties.
4338317 Phenoxyethyl-1,2,4,-triazol-3-one antidepressants July 6, 1982
Phenoxyethyl substituted-1,2,4,-triazolones having antidepressant properties typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one are disclosed.
4320131 N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiro alkanediones and N-[(4-hydroxy- March 16, 1982
N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiroalkanediones having substituents in the phenyl ring have been synthesized and demonstrate useful tranquilizing properties. N-[(4-Hydroxy-4-phenylpiperidin-1-yl)alkylene]azaspiroalkanediones are intermediates in their synthe
4305944 N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones December 15, 1981
2-[4-[4-(7,9-Dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-1-piperazinyl]pyridine- 3-carbonitrile, 2-[4-[4-(7,9-dioxo-8-azaspiro-[4.5]decan-8-yl)butyl]-3-methyl-1-piperaziny l]pyridine-3-carbonitrile and 8-[4-[4-(3-methoxy-2-pyridinyl)-1-piperazinyl]butyl]-8-azaspiro-[4.5]decan e-7,9-dione
4298734 Diazaheterocyclopurines and triazolopyrimidines November 3, 1981
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophyl
4286093 9-Cyclohexyl-2-alkoxy-9H-adenine process August 25, 1981
A process for preparing 9-cyclohexyl-2-alkoxy-9H-adenine derivatives such as 9-cyclohexyl-2-n-propoxy-9H-adenine from 7-amino-5-(methylthio)[1,2,5]oxadiazolo[3,4-d]pyrimidine and 7-amino-5-(methylthio)[1,2,5]thiadiazolo[3,4-d]pyrimidine is described. Other aspects of the invention ar
4234581 Thieno[2,3-d]oxazines November 18, 1980
2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate
4223031 Azolopyrimidinones September 16, 1980
6-(1H-Tetrazol-5-yl)thiozolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo-pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on
4159377 Selected thieno[2,3-d]pyrimidines June 26, 1979
2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate
4054656 Thieno[2,3-d]pyrimidine antiallergic agents October 18, 1977
2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate










 
 
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