| Patent Number |
Title Of Patent |
Date Issued |
| 6642355 |
Endothelin-antagonizing peptide |
November 4, 2003 |
| The invention relates to an endothelin antagonistic peptide of the formula (I):wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X.sup.1 -Gly or ##STR1## and Y represents hydroxy, lower alkoxy, amino, # |
| 6194195 |
Strains of streptomyces producing endothelin antagonistic peptides |
February 27, 2001 |
| The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides. |
| 5874592 |
Physiologically active substance EI-2128-1 |
February 23, 1999 |
| The present invention relates to a novel compound EI-2128-1 having IL-1 production inhibitory activity which is represented by formula (I): ##STR1## |
| 5804599 |
Interleukin-1 production inhibiting compound |
September 8, 1998 |
| Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl. |
| 5686485 |
Physiologically active EI-1941 compounds |
November 11, 1997 |
| The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R.sup.1 and R.sup.2 is hydrogen and the other is hydroxy, or R.sup.1 and R.sup.2 together represent oxygen; and R.su |
| 5639860 |
Endothelin-antagonizing peptide |
June 17, 1997 |
| Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 repres |
| 5631222 |
Endothelin-antagonizing peptide |
May 20, 1997 |
| Disclosed is a peptide compound represented by the following formula (I):wherein R.sup.1-12, R.sup.14-18, and R.sup.20 are as defined in the specification. |
