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Tanaka; Takeo
Machida, JP
No. of patents:

Patent Number Title Of Patent Date Issued
6642355 Endothelin-antagonizing peptide November 4, 2003
The invention relates to an endothelin antagonistic peptide of the formula (I):wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X.sup.1 -Gly or ##STR1## and Y represents hydroxy, lower alkoxy, amino, #
6194195 Strains of streptomyces producing endothelin antagonistic peptides February 27, 2001
The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.
5874592 Physiologically active substance EI-2128-1 February 23, 1999
The present invention relates to a novel compound EI-2128-1 having IL-1 production inhibitory activity which is represented by formula (I): ##STR1##
5804599 Interleukin-1 production inhibiting compound September 8, 1998
Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.
5686485 Physiologically active EI-1941 compounds November 11, 1997
The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R.sup.1 and R.sup.2 is hydrogen and the other is hydroxy, or R.sup.1 and R.sup.2 together represent oxygen; and
5639860 Endothelin-antagonizing peptide June 17, 1997
Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 repres
5631222 Endothelin-antagonizing peptide May 20, 1997
Disclosed is a peptide compound represented by the following formula (I):wherein R.sup.1-12, R.sup.14-18, and R.sup.20 are as defined in the specification.

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