| Patent Number |
Title Of Patent |
Date Issued |
| 7553974 |
Crystal of (2R,4R)-monatin potassium salt and sweetener composition containing same |
June 30, 2009 |
| Crystals of (2R,4R)-monatin potassium salt which exhibit an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2.theta. of 5.5.degree., 7.2.degree., 8.1.degree., 8.9.degree., and 16.3.degree., by powder X-ray diffraction (Cu--K.alpha. radiation), are s |
| 7534590 |
Method for producing monatin |
May 19, 2009 |
| A solution to be treated containing monatin and impurities is treated with a nonpolar resin having aromatic rings, whereby monatin is separated from the solution. Treatment with the nonpolar resin having aromatic rings results in efficient separation of monatin under a mild pH condition. |
| 7396941 |
Method for producing monatin |
July 8, 2008 |
| By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organic solvent, and the crystallization of monatin in th |
| 7390909 |
Processes of producing glutamic acid compounds and production intermediates therefore and novel |
June 24, 2008 |
| The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. |
| 7297800 |
Process of producing glutamate derivatives |
November 20, 2007 |
| The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted .alpha.-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing |
| 7238830 |
N-alkylaspartyl dipeptide ester compounds |
July 3, 2007 |
| The present invention provides N-alkylaspartyl dipeptideester compounds and salts thereof, such as N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-.alpha.-aspartyl]-L-- phenylalanine 1-methyl ester, which provide high degrees of sweetness in comparison to conventional products, c |
| 7141263 |
Process for producing cinnamaldehyde derivatives, use thereof and the like |
November 28, 2006 |
| A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, i |
| 7064219 |
Processes of producing glutamic acid compounds and production intermediates therefore and novel |
June 20, 2006 |
| The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. |
| 6965055 |
Process for producing cinnamaldehyde derivatives, use thereof and the like |
November 15, 2005 |
| A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, i |
| 6939987 |
Method for producing Aspartame derivative, method for purifying the same, crystals thereof and u |
September 6, 2005 |
| N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-.alpha.-aspartyl]-L-phenylalan ine 1-methyl ester is prepared by a process comprising: subjecting Aspartame and 3-(3-methoxy-4-hydroxyphenyl)propionaldehyde or derivatives thereof to reductive alkylation in a solvent to produce N-[N-[3-(3-me |
| 6914151 |
Crystallization processes for the formation of stable crystals of aspartame derivative |
July 5, 2005 |
| A crystallization process for forming a stable crystal of N-(3,3-dimethylbutyl)-APM, which comprises using either water or a mixture of water with a lower alcohol as the crystallizing solvent and controlling the crystallization point to 30.degree. C. or above; and another crystalliza |
| 6899912 |
Method for producing aspartame derivative, method for purifying the same, crystals thereof and u |
May 31, 2005 |
| N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-.alpha.-aspartyl]-L-phenylalan ine 1-methyl ester is prepared by a process comprising: subjecting Aspartame and 3-(3-methoxy-4-hydroxyphenyl)propionaldehyde or derivatives thereof to reductive alkylation in a solvent to produce N-[N-[3-(3-me |
| 6844465 |
Method for preparing highly stable crystals of aspartame derivative |
January 18, 2005 |
| Disclosed in the present application are a method for preparing highly-stable A-type crystals by controlling and maintaining the product temperature of B-type N-(3,3-dimethylbutyl)-APM crystals at 25 to 80.degree. C. under an absolute humidity of 0.203 kg/kg or less environment, ther |
| 6841183 |
Process for producing aspartame derivatives, process for purifying aspartame derivatives, produc |
January 11, 2005 |
| N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-.alpha.-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspartame to a re |
| 6822111 |
Process for production of aspartyl dipeptide ester derivatives |
November 23, 2004 |
| N-[N-[3-(phenyl having various substituent group(s) on the benzene ring)propyl]-L-.alpha.-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced on an industrial scale at a high yield by reductively alkylating aspartame with |
| 6794531 |
Process for production of aspartyl dipeptide ester derivative, novel production intermediate the |
September 21, 2004 |
| The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes. |
| 6706304 |
Granular sweetener |
March 16, 2004 |
| Herein is disclosed a granulated sweetener comprising Aspartame and Acesulfame-K as active ingredients, wherein the amount of the Acesulfame-K is 5 to 90% by weight based on the total amount of both the components and wherein the maximum particle size of the granules is about 1,400 .mu.m |
| 6693214 |
Intermediate for sweetener with high sweetness and process for producing the same |
February 17, 2004 |
| The present invention relates to a 3-substituted-phenyl-3-merthylbutyric acid and 3-substituted-phenyl-3-merthylaldehyde derivatives, which are useful in the production of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-.alpha.-aspartyl]-L-p henylalanine 1-methyl ester, which is |
| 6689902 |
Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same |
February 10, 2004 |
| 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-.alpha.-aspartyl]-L-ph enylalanine 1-methyl ester, which |
| 6630191 |
Aspartyl dipeptide ester derivatives and sweeteners |
October 7, 2003 |
| The present invention relates to novel, aspartyl dipeptide ester derivatives and salts thereof, such as N-[N-(3-(3-hydroxy-4-methoxyphenyl)propyl]-L-.alpha.-aspartyl]-L-(.alpha.- methyl)phenylalanine 1-methyl ester which provide high degrees of sweetness in comparison to conventional |
| 6548096 |
Aspartyl dipeptide ester derivatives and sweeteners |
April 15, 2003 |
| Low-calory sweeteners comprising novel aspartyl dipeptide ester derivatives and their salts have a sweetening potency of up to 35000 times that of sugar and include compounds such as N-[N-[3-(3-methyl-4-hydroxyphenyl)propyl]-L-.alpha.-aspartyl]-L-phenylalan ine 1-methyl ester and |
| 6399132 |
Sweetener composition |
June 4, 2002 |
| Herein is disclosed a sweetener composition containing Aspartame and Acesulfame-K as active ingredients, wherein the amount of Acesulfame-K is 5 to 90% by weight based on the total amount of both the components and wherein the particle sizes of the both the components are respectively |
| 6335461 |
Process for purification of aspartame derivative |
January 1, 2002 |
| In the separation and purification of N-[N-(3,3-dimethylbutyl)-L-.alpha.-aspartyl]-L-phenylalanine methyl ester produced in the reductive alkylation of aspartame (APM) with 3,3-dimethylbutylaldehyde, the APM used in the starting material for the alkylation, which is difficult to be s |
| 6316657 |
Process for purification or recovery of sweetener |
November 13, 2001 |
| There is provided a process for purification of N-(3,3-dimethylbutyl)-.alpha.-L-aspartyl-L-phenylalanine methyl ester comprising the step of contacting impure N-(3,3-dimethylbutyl)-.alpha.-L-aspartyl-L-phenylalanine methyl ester containing at least .alpha.-L-aspartyl-L-phenylalanine |
| 6238727 |
Ruminant feed additive composition and process for producing the same |
May 29, 2001 |
| A ruminant feed additive composition containing (A) lysine magnesium phosphate, (B) magnesium oxide, (C) a binder and (D) water, said water content being between 5 and 15% by weight, and processes for producing the composition. |
| 6022581 |
Aggregate crystals of phosphoric acid/lysine/magnesium composite salt and process for producing |
February 8, 2000 |
| Spherical aggregate crystals of a phosphoric acid/lysine/magnesium composite salt represented by formula (1):whereR is a lysine cation;a is 0.15 to 1.0;b is 1.0 to 1.42;c is 0 to 0.3;n is 0 to 10; anda+(2.times.b)+c=3. |
| 6010733 |
Aspartylamide derivatives and sweeteners |
January 4, 2000 |
| Novel aspartylamide derivatives such as N-(.alpha.-L-aspartyl-(1R,2S,4S)-1-methyl-2-hydroxy-4-phenylhexylamide, N-.alpha.-7(N'-3,3-dimethylbutylaspartyl)-(1R,2S,4S)-1-methyl-2-hydroxy-4- phenylhexylamide) and the like, and a sweetener containing the above-mentioned derivatives or salt |
| 5968581 |
Dipeptide derivatives and sweetening agents |
October 19, 1999 |
| Novel dipeptide derivatives, such as N-3,3-dimethylbutyl-.alpha.-L-aspartyl-.alpha.-methyl-L-phenylalanine methyl ester and N-3,3-dimethylbutyl-.alpha.-L-aspartyl-.alpha.-methyl-L-tyrosine methyl ester, and sweetening agents comprising, as the active ingredient, anyone of the der |
| 5958496 |
Aspartyl dipeptide amide derivatives and sweeteners |
September 28, 1999 |
| Novel aspartyldipeptidoamides and salts thereof. The apartyldipeptides are useful as a low-calorie sweetener for food and beverage products and have excellent taste and chemical stability. |
| 5856579 |
Adduct salts of novel substituted benzylamines and a process for optically resolving them |
January 5, 1999 |
| A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active N-acyl-phenylalanine, -aspartic acid, or -glutamic acid, and separating the diastereomers formed by making us |
| 5795612 |
Aspartyldipeptideamine derivatives and sweetner |
August 18, 1998 |
| Novel aspartyldipeptideamide derivatives of formula (I):and salts thereof, wherein X is a D-.alpha.-amino acid residue or a DL-.alpha.-amino acid residue selected from the group consisting of D-alanine, D-.alpha.-aminobutyric acid, D-norvaline, D-valine, D-norleucine, D-leucine, D-isoleu |
| 5763657 |
Phosphoric acid-amino acid-polyvalent metal composite salt and ruminant feed additive compositio |
June 9, 1998 |
| The present specification discloses a ruminant feed additive composition which contains as an active ingredient a phosphoric acid-amino acid-polyvalent metal composite salt (final composite salt) which is insoluble in neutral or alkaline water and is soluble in acidic water and which |
| 5723651 |
Process for producing .alpha.-l-aspartyldipeptide amide derivatives |
March 3, 1998 |
| An economical process for producing .alpha.-L-aspartyldipeptide amide derivatives useful as sweeteners, by using amino protecting groups which can be removed by hydrolysis under acidic conditions, resulting in conversion of a .beta.-carboxyl acid ester to a carboxylic acid. |
| 5723165 |
Aspartyldipeptide derivatives and sweetener compositions containing the same |
March 3, 1998 |
| Aspartyldipeptide compounds of the formula (I)where R.sub.1 is alkyl or alkoxymethyl, R.sub.2 is phenyl, benzyl, cyclohexyl or cyclohexylmethyl, C* has an (S) configuration when R.sub.1 is alkyl and an (R) configuration when R.sub.1 is alkoxymethyl and X is a residue of a D-.alpha.-amino |
| 5679857 |
Method of preparing D-amino acid-N-(S)-.alpha.-alkylbenzylamide |
October 21, 1997 |
| L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)-.alpha.-alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, which is racemized at the amino |
| 5629450 |
Addition salt of acyl-amino acid and .alpha.-aryl amine and process for optical resolution of .a |
May 13, 1997 |
| To produce optically active .alpha.-arylalkylamine from optically impure .alpha.-arylalkylamine.Optically impure .alpha.-arylalkylamine is mixed with optically active N-acyl-aspartic acid or glutamic acid in a solvent and the resulting two types of diastereomer salts are optically resolv |
| 5616791 |
Method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic acid-(S)-N-.alpha.-alkylbenzylam |
April 1, 1997 |
| The present invention provides a method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic acid-(S)-N-.alpha.-alkylbenzylamide which is less expensive and more efficient than previous methods using N-protected-L-aspartic anhydride. |
| 5616766 |
Method for recovering L-phenylalanine |
April 1, 1997 |
| The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalani |
| 5581009 |
Process for crystallization of L-phenylalanine monomethyl sulfate using added salt |
December 3, 1996 |
| A process for improving the yield of crystallization of L-phenylalanine monomethyl sulfate from an aqueous solution containing L-phenylalanine and monomethyl sulfate, by adding an effective crystallization improving amount of a salt of an inorganic or organic acid with an alkali metal, a |
| 5532407 |
Process for recovering L-phenylalanine |
July 2, 1996 |
| An industrial process for recovering L-phenylalanine in high yield from a side stream obtained from .alpha.-APM is disclosed. L-aspartic acid or an aqueous solution thereof is added to such a side stream when hydrolysis of the side stream is performed under acidic conditions with a miner |
| 5530155 |
Process for recovering L-phenylalanine |
June 25, 1996 |
| Addition of a reaction mixture obtained by the mineral acid hydrolysis of at least one side flow generated from the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester to a crystallization slurry containing L-phenylalanine while maintaining the pH of the slurry at 3-8 by ad |
| 5466864 |
Method for recovering L-phenylalanine |
November 14, 1995 |
| The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalani |
| 5466864 |
Method for recovering L-phenylalanine |
November 14, 1995 |
| The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalani |
| 5432262 |
Method of purifying .alpha.-L-aspartyl-L-phenylalanine methyl ester |
July 11, 1995 |
| Mixture containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine are brought into contact with hydrochloric acid in an aqueous solvent to precipitate .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride and 3-benzyl-6-carbox |
| 5424476 |
Method for preparing amino acid esters |
June 13, 1995 |
| A method for preparing an amino acid ester with sulfuric acid as the catalyst in high yield, in which a mixture of amino acid, sulfuric acid and an alcohol is heated while adding the alcohol as a liquid or gas to the reaction mixture and alcohol from the reaction mixture is distilled |
| 5420338 |
Method for the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride |
May 30, 1995 |
| A method is disclosed for the production of .alpha.-APM HCl by treating an F-.alpha.-AP derivative with a mixed solvent of methanol, hydrochloric acid and water, wherein the solubility of .alpha.-APM HCl is lowered to increase the separation yield thereof. |
| 5391809 |
Method for the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride |
February 21, 1995 |
| A method is disclosed for the production of .alpha.-APM.HCl by treating an F-.alpha.-AP derivative with a mixed solvent of methanol, hydrochloric acid and water, wherein the solubility of .alpha.-APM.HCl is lowered to increase the separation yield thereof. |
| 5358186 |
Method of preparing granules of dipeptide |
October 25, 1994 |
| In producing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a particle size of falling within a determined particle size range by compaction granulation, formation of fine powdery .alpha.-APM is prevented by breaking the compacted .alpha.-APM so that the one-pass yiel |
| 5304671 |
Method for recovery of .alpha.-L-aspartyl-L-phenylalanine methyl ester, L-phenylalanine and L-as |
April 19, 1994 |
| A method for the recovery of .alpha.-L-aspartyl-L-phenylalanine methyl ester, L-phenylalanine and L-aspartic acid from the mother liquor obtained by the solid-liquid separation of a suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester crystals is disclosed. |
| 5294714 |
2,5-dioxopiperazine compounds and method for preparing .alpha.-aspartyl-L-phenylalanine methyl e |
March 15, 1994 |
| A method of preparing .alpha.-APM derivatives without using an expensive L-phenylalanine is provided, wherein 2,5-dioxopiperazine-3-acetamide is reacted with acetic anhydride to give N,N'-diacetyl-6-cyanomethyl-2,5-dioxopiperazine, which is then reacted with benzaldehyde in the prese |
