| Patent Number |
Title Of Patent |
Date Issued |
| 7553830 |
Compositions for the delivery of negatively charged molecules |
June 30, 2009 |
| This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex |
| 7041817 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
May 9, 2006 |
| Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. |
| 6972330 |
Chemical synthesis of methoxy nucleosides |
December 6, 2005 |
| Process for chemical synthesis of methoxy nucleosides. |
| 6686463 |
Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives |
February 3, 2004 |
| The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside deri |
| 6649751 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
November 18, 2003 |
| Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification. |
| 6617438 |
Oligoribonucleotides with enzymatic activity |
September 9, 2003 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to |
| 6528640 |
Synthetic ribonucleic acids with RNAse activity |
March 4, 2003 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to |
| 6509460 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
January 21, 2003 |
| Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed. |
| 6482932 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
November 19, 2002 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. |
| 6469158 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
October 22, 2002 |
| Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. |
| 6437117 |
Synthesis, deprotection, analysis and purification for RNA and ribozymes |
August 20, 2002 |
| Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. |
| 6395713 |
Compositions for the delivery of negatively charged molecules |
May 28, 2002 |
| This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers. |
| 6127535 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
October 3, 2000 |
| Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed. |
| 5962675 |
Chemical syntheses of 2'-O-methoxy purine nucleosides |
October 5, 1999 |
| Several processes for the chemical synthesis of 2'-O-methoxy purine nucleosides are herein disclosed. |
| 5631360 |
N-phthaloyl-protected 2'-amino-nucleoside phosphoramdites |
May 20, 1997 |
| A method for blocking the 2'-amino group of a nucleoside phosphoramidite using an N-phthaloyl protecting group. The 2'-amino-N-phthaloyl protected nucleotides are also disclosed. |
