| Patent Number |
Title Of Patent |
Date Issued |
| 7547675 |
Chemically modified polypeptides |
June 16, 2009 |
| The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypep |
| 7291713 |
Branched polyalkylene glycols |
November 6, 2007 |
| The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into |
| 6642355 |
Endothelin-antagonizing peptide |
November 4, 2003 |
| The invention relates to an endothelin antagonistic peptide of the formula (I):wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X.sup.1 -Gly or ##STR1## and Y represents hydroxy, lower alkoxy, amino, # |
| 6638509 |
Toxin conjugates |
October 28, 2003 |
| The present invention relates to a toxin conjugate in which a residue derived from a compound having an affinity for a target cell is bound to a toxin through a spacer comprising polyalkylene glycol and dipeptide. |
| 6583267 |
Chemically modified polypeptides |
June 24, 2003 |
| The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide |
| 6194195 |
Strains of streptomyces producing endothelin antagonistic peptides |
February 27, 2001 |
| The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides. |
| 6103236 |
Toxin conjugates |
August 15, 2000 |
| The present invention relates to a toxin conjugate in which a residue derived from a compound having an affinity for a target cell is bound to a toxin through a spacer comprising polyalkylene glycol and dipeptide. |
| 5639860 |
Endothelin-antagonizing peptide |
June 17, 1997 |
| Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 repres |
| 5631222 |
Endothelin-antagonizing peptide |
May 20, 1997 |
| Disclosed is a peptide compound represented by the following formula (I):wherein R.sup.1-12, R.sup.14-18, and R.sup.20 are as defined in the specification. |
