| Patent Number |
Title Of Patent |
Date Issued |
| 6747158 |
Efficient process for the preparation of a factor Xa inhibitor |
June 8, 2004 |
| The present invention relates to the process for the preparation of the compound of Formula I: ##STR1##from its corresponding 3-cyano-4-fluorophenyl-pyrazole and intermediates useful therein. |
| 6667332 |
Efficient process for the preparation of a factor Xa inhibitor |
December 23, 2003 |
| The present invention relates to the process for the preparation of the compound of Formula I: ##STR1##from its corresponding 3-cyano-4-fluorophenyl-pyrazole and intermediates useful therein. |
| 6521614 |
N-(amidinophenyl)cyclourea analogs as factor Xa inhibitors |
February 18, 2003 |
| The present application describes N-(amidinophenyl)cyclourea analogs of formula I: ##STR1##which are useful as inhibitors of factor Xa. |
| 5925635 |
N-(amidinophenyl) cyclourea analogs as factor XA inhibitors |
July 20, 1999 |
| The present application describes N-(amidinophenyl)cyclourea analogs of formula I: ##STR1## which are useful as inhibitors of factor Xa. |
| 5641782 |
3-aromatic and 3-heteroaromatic substituted bisnaphthalimides |
June 24, 1997 |
| This invention relates to 3-Pyrimidinyl Bisnaphthalimides as Anticancer Agents and pharmaceutically acceptable salts thereof, of the formula: ##STR1## and processes for the preparation of such compounds, pharmaceutical composition containing such compounds, and methods of using such |
| 5532357 |
Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas |
July 2, 1996 |
| The present invention relates generally to methods for the preparation of unsymmetrically substituted cyclic ureas of the formulae ##STR1## which are useful as HIV protease inhibitors. The methods provided go through an isourea intermediate. |
| 5488110 |
Highly water soluble bis-naphthalimides useful as anticancer agents |
January 30, 1996 |
| This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis(methylimino-2,1-ethanediyl)]-bis[5-nitro-1H-benz[d e]isoquinoline-1,3(2H)-dione], 2-[2-[N-methyl-N-[2-[[2-(5-nitro-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-y l)ethyl]amino]ethyl]amino]ethyl]-5-nitro-1H-benz[ |
| 5461176 |
Processes for preparing bis-naphthalimides containing amino-acid derived linkers |
October 24, 1995 |
| This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione], process |
| 5376664 |
Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
December 27, 1994 |
| This invention relates to unsymmetrical mono-3-nitro bis-naphthalimides of formula ##STR1## including (R,R)-2-{2-[2-((2-(1,3-dioxo-1H-benz[de]isoquinolin-2-(3H)-yl)-propylamino ))ethylamino]-1-methylethyl}-5-nitro-1H-benz[de]isoquinolin-1,3-(2H)-dione, processes for their prep |
| 5329048 |
Process of preparing tetraamino intermediates |
July 12, 1994 |
| This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methy1-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione], process |
| 5206250 |
Bis-naphthalimides containing amide and thioamide linkers as anticancer agents |
April 27, 1993 |
| There are provided novel bis-naphthalimide compounds useful as antitumor agents, pharmaceutical compositions containing them and processes for preparing such compounds. |
| 5206249 |
Bis-naphthalimides containing amino-acid derived linkers as anticancer agents |
April 27, 1993 |
| This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione], process |
| 5126364 |
4-amino-5-chloro-n-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]fura n-7-carboxamide and pharmaceuti |
June 30, 1992 |
| The compound (R) (-)-4-amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]furan-7-c arboxamide; the S isomer thereof, and pharmaceutical compositions containing the same. |
| 5086059 |
Bis-naphthalimides as anticancer agents |
February 4, 1992 |
| There are provided novel bis-napthalimide compounds useful as antitumor agents, pharmaceutical compositions containing them and processes for preparing intermediates to such compounds. |
