| Patent Number |
Title Of Patent |
Date Issued |
| 6159938 |
Serine protease inhibitors comprising .alpha.-keto heterocycles |
December 12, 2000 |
| Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of ischemic heart or treatment of symptoms associated with blood coagulation disorders. Also |
| 6075120 |
Bradykinin antagonist |
June 13, 2000 |
| A bradykinin antagonist of the formula:where BKAn is a bradykinin antagonist peptide; Y is a pharmacore; and X is a bridging link chemically joining the BKAn and Y components. |
| 6037325 |
Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil e |
March 14, 2000 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase. |
| 5891852 |
Serine protease inhibitors-cycloheptane derivatives |
April 6, 1999 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi |
| 5874585 |
Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil e |
February 23, 1999 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase. |
| 5869455 |
Serine protease inhibitors-N-substituted derivatives |
February 9, 1999 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi |
| 5863899 |
Bradykinin antagonists |
January 26, 1999 |
| A bradykinin antagonist of the formula:where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components. |
| 5861380 |
Serine protease inhibitors-keto and di-keto containing ring systems |
January 19, 1999 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi |
| 5843900 |
Bradykinin antagonists |
December 1, 1998 |
| The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component. |
| 5807829 |
Serine protease inhibitor--tripeptoid analogs |
September 15, 1998 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi |
| 5801148 |
Serine protease inhibitors-proline analogs |
September 1, 1998 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi |
| 5663416 |
Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase |
September 2, 1997 |
| 2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase. |
| 5618792 |
Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil e |
April 8, 1997 |
| The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase. |
| 5214191 |
Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase |
May 25, 1993 |
| 2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase. |
