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Inventor:
Spruce; Lyle W.
Address:
Arvada, CO
No. of patents:
14
Patents:












Patent Number Title Of Patent Date Issued
6159938 Serine protease inhibitors comprising .alpha.-keto heterocycles December 12, 2000
Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of ischemic heart or treatment of symptoms associated with blood coagulation disorders. Also
6075120 Bradykinin antagonist June 13, 2000
A bradykinin antagonist of the formula:where BKAn is a bradykinin antagonist peptide; Y is a pharmacore; and X is a bridging link chemically joining the BKAn and Y components.
6037325 Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil e March 14, 2000
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.
5891852 Serine protease inhibitors-cycloheptane derivatives April 6, 1999
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi
5874585 Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil e February 23, 1999
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.
5869455 Serine protease inhibitors-N-substituted derivatives February 9, 1999
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi
5863899 Bradykinin antagonists January 26, 1999
A bradykinin antagonist of the formula:where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
5861380 Serine protease inhibitors-keto and di-keto containing ring systems January 19, 1999
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi
5843900 Bradykinin antagonists December 1, 1998
The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.
5807829 Serine protease inhibitor--tripeptoid analogs September 15, 1998
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi
5801148 Serine protease inhibitors-proline analogs September 1, 1998
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septi
5663416 Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase September 2, 1997
2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase.
5618792 Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil e April 8, 1997
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.
5214191 Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase May 25, 1993
2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase.










 
 
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