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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Spiegelman; Bruce M.
Address:
Waban, MA
No. of patents:
21
Patents:












Patent Number Title Of Patent Date Issued
8105774 PGC-1.beta., PGC-1 homologue and uses therefor January 31, 2012
The invention provides isolated nucleic acid molecules, designated PGC-1.beta. nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1.beta. nucleic a
7947652 Compositions and methods for modulating PGC-1.alpha. to treat huntington's disease May 24, 2011
The present invention provides methods for modulating mitochondrial function, modulating lesion formation in the brain, modulating neurite growth, modulating neuronal degeneration, and treating and preventing neurological diseases or disorders comprising modulating the expression or
7691578 Methods and compositions for treating obesity April 6, 2010
The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject. The present invention also relates to the use of PGC-1 expression levels to determine the safe dosage range for known or putative respiration uncou
7635708 Methods and pharmaceutical compositions for inhibiting tumor cell growth December 22, 2009
The present invention is based on the finding that activation of PPAR.gamma. plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR.gamma. agonists, such as thiazolidinedione ligands (TZDs), is effec
7371529 Methods and compositions for modulating gluconeogenesis using PGC-1 May 13, 2008
The invention provides novel methods and compositions for modulating gluconeogenesis through modulation of PGC-1 activity or expression. Also provided are methods for identifying compounds that modulate gluconeogenesis through modulation of PGC-1 activity or expression, as well as me
7354738 PGC-1.beta., a novel PGC-1 homologue and uses therefor April 8, 2008
The invention provides isolated nucleic acid molecules, designated PGC-1.beta. nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1.beta. nucleic a
7250283 PGC-1 isoforms and uses therefor July 31, 2007
The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid
7091006 PGC-1.beta., a novel PGC-1 homologue and uses therefor August 15, 2006
The invention provides isolated nucleic acid molecules, designated PGC-1.beta. nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1.beta. nucleic a
6974671 Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to December 13, 2005
In accordance with the present invention, it has been discovered that CREB regulates hepatic gluconeogenesis via the co-activator, PGC-1. PGC-1 potentiated glucocorticoid induction of the gene for PEPCK, the rate limiting enzyme in gluconeogenesis, via the glucocorticoid response unit
6908987 PCG-1, a novel brown fat PPAR.gamma. coactivator June 21, 2005
The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention
6872391 PGC-1, a novel brown fat PPAR.gamma. coactivator March 29, 2005
The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention
6586455 Treatment of liposarcomas using a combination of thiazolidinediones and retinoid X receptor sele July 1, 2003
In accordance with the present invention, it has been discovered that PPAR.gamma. is expressed consistently in each of the major histologic types of human liposarcoma. It has further been discovered that maximal activation of PPAR.gamma. with exogenous ligand (a thiazolidinedione or
6552055 Methods and pharmaceutical compositions for inhibiting tumor cell growth April 22, 2003
The present invention is based on the finding that activation of PPAR.gamma. plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR.gamma. agonists, such as thiazolidinedione ligands (TZDs), is effec
6525178 PGC-1, a novel brown fat PPARgamma coactivator February 25, 2003
The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention
6426411 PGC-1, a novel brown fat ppar.gamma. coactivator July 30, 2002
The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention
6242196 Methods and pharmaceutical compositions for inhibiting tumor cell growth June 5, 2001
A method for inhibiting proliferation of a PPAR .gamma.-responsive hyperproliferative cell which comprises the step of contacting the cell with (I) an inhibitory amount of a PPAR.gamma. agonist and (II) a MAP kinase inhibitor is disclosed. A method for treating or prophylactically pr
6166192 PGC-1, a novel brown fat PPAR.gamma. coactivator December 26, 2000
The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention
6015558 Treatment of insulin resistance in obesity linked type II diabetes using antagonists to TNF-.alp January 18, 2000
An induction of TNF-.alpha. mRNA expression has been observed in adipose tissue from four different insulin resistant rodent models of obesity and diabetes. TNF-.alpha. protein was also elevated locally and systemically. Neutralization of TNF-.alpha. in obese fa/fa rats caused a signific
5730975 Treatment of insulin resistance in obesity linked type II diabetes using antagonist to TNF-alpha March 24, 1998
An induction of TNF-.alpha. mRNA expression has been observed in adipose tissue from four different insulin resistant rodent models of obesity and diabetes. TNF-.alpha. protein was also elevated locally and systemically. Neutralization of TNF-.alpha. in obese fa/fa rats caused a signific
5476926 Adipocyte-specific DNA sequences and use thereof in the production of transgenic animals exhibit December 19, 1995
Regulatory DNA sequences are provided, which are obtained from the 5' flanking region of genes which are expressed primarily in differentiated adipose tissue. These DNA sequences are largely responsible for driving the expression of endogenous genes specifically in adipose tissue in vivo
5306729 Method for effecting vasodilation with monoglycerides April 26, 1994
The invention provides a novel method of effecting vasodilation in a warm-blooded animal in need of such treatment and involves administering to a warm-blooded animal an effective amount of a vasodilatory monoglyceride of the formula: ##STR1## wherein R is a straight or branched










 
 
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