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Inventor: Smith; Graeme Cameron Murray
Address: Cambridge, GB
No. of patents: 11
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 7470688 |
Phthalazinone derivatives |
December 30, 2008 |
| A compound of the formula (I): ##STR00001## wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) ##STR00002## where Y.sup.1 is selected from CH and N, Y.sup.2 is selected from CH and N, Y.sup.3 is selected from CH, CF and N; |
| 7429660 |
ATM inhibitors |
September 30, 2008 |
| A compound of formula I: ##STR00001## and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R.sup.1 and R.sup.2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 r |
| 7407957 |
Phthalazinone derivatives |
August 5, 2008 |
| A compound of formula (I): ##STR00001## for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NR.sup.X or CR.sup.XR.sup.Y; if X=NR.sup.X then n is 1 or 2 and if |
| 7402607 |
DNA-PK inhibitors |
July 22, 2008 |
| A compound of formula I: ##STR00001## and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R.sup.1 and R.sup.2 are independently selected from hydrogen, an optionally substituted C.sub.1-7 alkyl group, C.sub.3-20 heterocyclyl group, or C.sub.5-2 |
| 7226918 |
DNA-PK inhibitors |
June 5, 2007 |
| The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R.sup.1 and R.sup.2 are independently hydrogen, an optionally |
| 7196085 |
Phthalazinone derivatives |
March 27, 2007 |
| A compound of formula: ##STR00001## or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; R.sup.L is a C.sub.5-7 aryl group substituted in the meta position by the group R.sup.2, |
| 7151102 |
Phthalazinone derivatives |
December 19, 2006 |
| A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula: ##STR00001## or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein: A |
| 7138236 |
Interactions of ATM, ATR or DAN-PK with p53 |
November 21, 2006 |
| The interaction of ATM and related protein kinases such as ATR and DNA-PK with p53 is disclosed, in particular the phosphorylation of Ser15 and Thr18 by these proteins. The activity of the proteins is shown to increase in the presence of DNA. Assays for modulators of phosphorylation |
| 7105518 |
Thiopyrane-4-ones as DNA protein kinase inhibitors |
September 12, 2006 |
| The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R.sup.1 and R.sup.2 are independently hydrogen, an option ally substituted C.sub.1-7 alkyl group, C.sub.3-20 heterocyclyl group, or C.sub.5- |
| 7049313 |
ATM inhibitors |
May 23, 2006 |
| The application concerns a compound of formula I: ##STR00001## wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R.sup.3 group; Y is either O or S; R.sup.1 and R.sup.2 are i |
| 6664269 |
Isoquinolinone derivatives |
December 16, 2003 |
| Derivatives of isoquinolinone and dihydrolisoquinolinone, and related compounds, and their use as pharmaceuticals in the treatment of a disease by inhibition of the enzyme poly(ADP-ribose)polymerase ("PARP") are disclosed. |
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