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Inventor:
Secrist, III; John A.
Address:
Birmingham, AL
No. of patents:
31
Patents:












Patent Number Title Of Patent Date Issued
8178510 Preparation of thioarabinofuranosyl compounds and use thereof May 15, 2012
Patients suffering from cancer are treated by being administered a compound represented by the following formula: ##STR00001## wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of ##STR00002## wherein X is selec
7838508 4'-thio-L-xyloy furanosyl nucleosides, precursors thereof, preparation and use thereof November 23, 2010
Compounds represented by the formula 1: ##STR00001## A is selected from the group consisting of ##STR00002## wherein each R individually is H or acyl, Y is X, N.sub.3, NH.sub.2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen,
7691820 Preparation of thioarabinofuranosyl compounds and use thereof April 6, 2010
Patients suffering from cancer are treated by being administered a compound represented by the following formula: ##STR00001## wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of ##STR00002## wherein X is selecte
7488598 Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof February 10, 2009
A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infec
7470784 Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-9H-purin-6-amin December 30, 2008
2-Chloro-9-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-.bet
7148223 4'-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof December 12, 2006
Compounds represented by the formula 1: ##STR00001## A is selected from the group consisting of ##STR00002## wherein each R individually is H or acyl, Y is X, N.sub.3, NH.sub.2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, hal
7138385 Thioarabinofuranosyl compounds and use thereof November 21, 2006
Patients suffering from cancer are treated by being administered a compound represented by the following formula: ##STR00001## wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of ##STR00002## wherein X is selecte
7037718 Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof May 2, 2006
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purin
6949640 Method for synthesizing 2-chloro-9-(2-fluoro-.beta.-D-arabinofuranosyl)-9H-purin-6-amine September 27, 2005
2-Chloro-9-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-.bet
6914061 4'-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof July 5, 2005
Compounds represented by the formula 1: ##STR1##A is selected from the group consisting of ##STR2## wherein each R individually is H or acyl, Y is X, N.sub.3, NH.sub.2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting of hydrogen, halo, hydr
6870052 Preparation of thioarabinofuranosyl compounds and use thereof March 22, 2005
Patients suffering from cancer are treated by being administered a compound represented by the following formula: ##STR1## wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of ##STR2## wherein X is selected from the
6576621 Preparation of thioarabinofuranosyl compounds and use thereof June 10, 2003
Patients suffering from cancer are treated by being administered a compound represented by the following formula: ##STR1##wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of ##STR2## wherein X is selected from the g
6503948 Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition January 7, 2003
A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the group consisting of compounds having formulas I, II, III, IV, V, VI, and VII is administered
6001840 Methods of treatment of viral infections using carbocyclic deoxyguanosine analogs December 14, 1999
Method for prophylaxis and treatment of a viral infection characterized by the administration of a composition comprising a substantial molar excess of the D-stereoisomer of 2'CdG over the L-stereoisomer.
5726311 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2-d]pyrimidine and pharmaceutical uses and composit March 10, 1998
Disclosed is a compound of the formula ##STR1## wherein R.sup.1 is H, NH.sub.2, or OCH.sub.3, R.sup.2 is an optionally substituted cyclic group optionally containing one or more heteroatoms, R.sup.3 and R.sup.4 are independently H or C.sub.1-4 alkyl, m is 0-4, n is 0-6, p is 0.1,
5721240 9-substituted-8-unsubstituted-9-deazaguanines February 24, 1998
The specification discloses the compounds of formula I ##STR1## wherein (a) --CH.sub.2 Ar represents ##STR2## in which R.sub.1 represents hydrogen, halogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, benzyloxy, hydroxy or trifluoromethyl; and R.sub.2 represents hydrog
5688774 A.sub.3 adenosine receptor agonists November 18, 1997
The present invention provides A.sub.3 selective agonists, particularly, adenine compounds having selected substituents at the 2, 6, and 9 positions, and related substituted compounds, particularly those containing substituents on the benzyl and/or uronamide groups, as well as pharma
5661136 2-halo-2'-fluoro ARA adenosines as antinoplastic agents August 26, 1997
The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.
5591722 2'-deoxy-4'-thioribonucleosides and their antiviral activity January 7, 1997
2'-Deoxy-4'-thio-ribonucleosides, intermediates in their production, and their use as antiviral and anticancer agents are disclosed.
5565463 9-subtituted-8-unsubstituted-9-deazaguanines October 15, 1996
The specification discloses the compounds of formula I ##STR1## wherein (a) --CH.sub.2 Ar represents ##STR2## in which R.sub.1 represents hydrogen, halogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, benzyloxy, hydroxy or trifluoromethyl; and R.sub.2 represents hydrog
5478928 2',3'-dideoxy-4'-thioribonucleosides and synthetic precursors thereof December 26, 1995
2',3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of the formula ##STR1## where X.dbd.H, N.sub.3 or F, and B is a member selected from the
5384310 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions January 24, 1995
The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.
5189039 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2d]pyrimidine and pharmaceutical uses and compositi February 23, 1993
Disclosed is a compound of the formula ##STR1## wherein R.sup.1 is H, NH.sub.2, or OCH.sub.3, R.sup.2 is an optionally substituted cyclic group optionally containing one or more heteroatoms, R.sup.3 and R.sup.4 are independently H or C.sub.1-4 alkyl, m is 0-4, n is 0-6, p is 0.1,
5128458 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents July 7, 1992
2'3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of the formula ##STR1## where X=H, N.sub.3 or F, and B is a member selected from the group
5102873 Adenosine compounds useful in the prevention and treatment of vaccinia virus infections April 7, 1992
Substituted 1-(benzyloxy)adenosines and the use of substituted 1-(benzyloxy)adenosines and adenosine-N.sup.1 -oxides in the prevention and treatment of vaccinia virus infections are disclosed.
5034518 2-fluoro-9-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl) adenine nucleosides July 23, 1991
There are disclosed nucleosides having Formula I: ##STR1## wherein R is H or acyl. These compounds have anticancer activity.
5008270 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and c April 16, 1991
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is an optionally substituted heteroalicyclic group, a pharmaceutical composition containing the compound, and a method for th
5008265 2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and com April 16, 1991
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is an optionally substituted alicyclic group, a pharmaceutical composition containing the compound, and a method for the sele
4985434 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical use January 15, 1991
Disclosed is a compound containing 2-amino-7-(R)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein R is optionally substituted cyclohexenyl or cyclohexyl, a pharmaceutical composition containing the compound, and a method for the selective suppresion of mammalian T-cell function without di
4985433 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and com January 15, 1991
Disclosed is a compound containing a 2-amino-7-(substituted methyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein substituted methyl is --CH.sub.2 --R wherein R is optionally substituted pyridinyl, a pharmaceutical composition containing the compound, and a method for the selective sup
4794174 5'deoxy-5'-substituted adenosines December 27, 1988
In accordance with this invention, there are provided 5'-deoxy-5'-substituted adenosines having the formula ##STR1## wherein X is a member selected from the group consisting of NH, NCH.sub.3, S, or ##STR2## n is an integer from 2-4; and Z is a member selected from the group










 
 
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