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Inventor:
Schreiner; George F.
Address:
Los Altos Hills, CA
No. of patents:
19
Patents:












Patent Number Title Of Patent Date Issued
7189739 Compounds and methods to treat cardiac failure and other disorders March 13, 2007
The invention is directed to compounds of the formula ##STR00001## and the pharmaceutically acceptable salts thereof wherein Ar.sup.1 is indole, benzimidazole, or benzotriazole, optionally substituted with lower alkyl (1 4C), halo, or lower alkoxy (1 4C); X.sup.1 is CO or an isostere
7030083 Treatment of eclampsia and preeclampsia April 18, 2006
The invention concerns the prevention and treatment of endothelial injury and the injury of tissues containing injured blood vessels by administration of angiogenic factors, such as vascular endothelial cell growth factor (VEGF).
6903096 Quinazoline derivatives as medicaments June 7, 2005
The invention is directed to methods to inhibit TGF-.beta. and/or p38-.alpha. kinase using compounds of the formula ##STR1##or the pharmaceutically acceptable salts thereof wherein R.sup.3 is a noninterfering substituent; each Z is CR.sup.2 or N, wherein no more than two Z positions in
6709855 Methods for detection and use of differentially expressed genes in disease states March 23, 2004
The present invention relates to methods and compositions for the detection, diagnosis, prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and related disorders. The present invention also relates to compositions and methods useful in the dia
6686354 Agonists and antagonists of peripheral-type benzodiazepine receptors February 3, 2004
The invention concerns the use of agonists and antagonists of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of cardiac hypertrophy and other circulatory conditions. The invention specifically concerns the use of PTBR antagonists in the prevention or t
6677300 Treatment of microvascular angiopathies January 13, 2004
The invention concerns the prevention and treatment of endothelial injury and the injury of tissues containing injured blood vessels by administration of angiogenic factors, such as vascular endothelial cell growth factor (VEGF).
6589954 Compounds and methods to treat cardiac failure and other disorders July 8, 2003
Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful in treating cardiac conditions associated with heart failure a
6541477 Inhibitors of p38-a kinase April 1, 2003
The invention is directed to methods for treating conditions mediated by by P38.alpha. kinase using compounds of the formula ##STR1##wherein Ar.sup.1 and Ph are limited to specific embodiments or wherein the compound of formula (3) is a compound set forth in FIGS. 1A-1T.
6476031 Quinazoline derivatives as medicaments November 5, 2002
The invention is directed to methods to inhibit TGF-.beta. and/or p38-.alpha. kinase using compounds of the formula ##STR1##or the pharmaceutically acceptable salts thereof wherein R.sup.3 is a noninterfering substituent; each Z is CR.sup.2 or N, wherein no more than two Z positions in
6448257 Compounds and methods to treat cardiac failure and other disorders September 10, 2002
Compounds of the formula: ##STR1## wherein the dotted line represents an optional bond; and the pharmaceutically acceptable salts thereof, wherein X.sup.1 is an alkyl bridge optionally containing an O, S, or N heteroatom that forms an aliphatic 5-7 membered ring and is optionally
6410540 Inhibitors of p38-.alpha.kinase June 25, 2002
The invention is directed to methods to treat conditions mediated by p38-.alpha.kinase using compounds of the formula ##STR1##and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof,whereinZ is N or CR.sup.1, R.sup.1 is a noninterfering substituent,each
6380183 Treatment of diseases involving cyst formation April 30, 2002
The invention concerns the use of ligands of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of diseases involving cyst formation and in particular polycystic kidney disease. The invention further concerns the treatment of hypertension accompanying polycyst
6352975 Methods of treating hypertension and compositions for use therein March 5, 2002
The present invention concerns methods for the treatment of salt-sensitive hypertension. The methods generally involve administering a vascular endothelial growth factor (VEGF) in an amount effective to reduce the blood pressure of a patient suffering from salt-sensitive hypertension to
6342495 Agonists and antagonists of peripheral-type benzodiazepine receptors January 29, 2002
The invention concerns the use of agonists and antagonists of peripheral-type benzodiazcpine receptors (PTBR) in the diagnosis and treatment of cardiac hypertrophy and other circulatory conditions. The invention specifically concerns the use of PTBR antagonists in the prevention or t
6340685 Compounds and methods to treat cardiac failure and other disorders January 22, 2002
A compound of the formula: ##STR1##and the pharmaceutically acceptable salts thereof,wherein each of Z.sup.1 and Z.sup.2 is independently CR.sup.4 or N;where each R.sup.4 is independently H or is alkyl (1-6C) optionally including one or more heteroatoms selected from O, S and N and optionall
6277989 Quinazoline derivatives as medicaments August 21, 2001
The invention is directed to methods to inhibit TGF-.beta. and/or p38-.alpha. kinase using compounds of the formula ##STR1##or the pharmaceutically acceptable salts thereofwherein R.sup.3 is a noninterfering substituent;each Z is CR.sup.2 or N, wherein no more than two Z positions in ring A
6184226 Quinazoline derivatives as inhibitors of P-38 .alpha. February 6, 2001
The invention describes compounds of the formula ##STR1##and the pharmaceutically acceptable salts thereofand the pharmaceutically acceptable salts thereofwherein each R.sup.2 is independently a noninterfering substituent;m is an integer of 0-4;Z is CH or N;R.sup.1 is H, alkyl (1-6C) or arylalky
6130235 Compounds and methods to treat cardiac failure and other disorders October 10, 2000
The invention is directed to compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein Ar.sup.1 is indole, benzimidazole, or benzotriazole, optionally substituted with lower alkyl (1-4C), halo, or lower alkoxy (1-4C);X.sup.1 is CO or an isostere ther
5789416 N.sup.6 mono heterocyclic substituted adenosine derivatives August 4, 1998
A substituted N.sup.6 -oxa, thia, thioxa and azacycloalkyl substituted adenosine derivative and a method for using the composition as an A.sub.1 heart adenosine receptor.










 
 
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