| Patent Number |
Title Of Patent |
Date Issued |
| 8129106 |
Sequence-specific detection of methylation in biomolecules |
March 6, 2012 |
| A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whether the recognition |
| 7781196 |
Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase |
August 24, 2010 |
| The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the A. calcoaceticus s-GDH wild-type |
| 7732179 |
Mutants of pyrroloquinoline quinone dependent soluble glucose dehydrogenase |
June 8, 2010 |
| A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position 348 by either glycine, alamine or serine, wherein said mutant additionally comprises, a |
| 7547535 |
Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
June 16, 2009 |
| The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these |
| 7547524 |
Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an am |
June 16, 2009 |
| The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known from Acinetobacter calcoaceticus, t |
| 7517664 |
Inactivated enzyme variants and associated process and reagent system |
April 14, 2009 |
| The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA s |
| 7348423 |
Nucleic acids encoding fusion peptides |
March 25, 2008 |
| A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressin |
| 7172890 |
Inactivated enzyme variants and associated process and reagent system |
February 6, 2007 |
| The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA s |
| 7132270 |
Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
November 7, 2006 |
| The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these |
| 6958231 |
Variants of Erwinia-type creatinase |
October 25, 2005 |
| The present invention relates to mutated genes encoding variants of an Erwinia-type creatinase (EC 3.5.3.3, alternative name: creatine amidinohydrolase), to the creatinase variants encoded by these genes, and to different applications of these variants of creatinase, particularly to |
| 6905689 |
Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production |
June 14, 2005 |
| A conjugate of a tissue non-specific alkaline phosphatase (tns-AP) and dextran which can be obtained by reacting unglycosylated tns-AP with activated dextran by incubation in aqueous solution, stopping the reaction and isolating the conjugate from the solution. The conjugate obtained in |
| 6902920 |
Method for producing an active heterodimeric AMV-RT in prokaryotic cells |
June 7, 2005 |
| The heterologous expression of the reverse transcriptase from the Avian Myeloblastosis Virus (AMV-RT) in prokaryotic cells and in particular Escherichia coli (E. coli) is described in the present invention. The invention also includes certain measures to simplify the purification of |
| 6858410 |
Process for making antifusogenic fusion peptides that form inclusion bodies |
February 22, 2005 |
| A process is provided for producing an antifusogenic peptide by producing a fusion peptide of from about 14 amino acids up to 70 amino acids in a prokaryotic host cell under conditions in which inclusion bodies are formed. The antifusogenic peptide recovered from the inclusion bodies is |
| 6255093 |
Recombinant microbial 3-hydroxybutyrate dehydrogenase a process for its production and the use t |
July 3, 2001 |
| DNA molecule comprising a structural gene which codes for a bacterial protein with the enzymatic activity of 3-hydroxybutyrate dehydrogenase (3-HBDH), a recombinant DNA containing the DNA molecule, microorganisms transformed accordingly, a process for obtaining 3-HBDH by culturing a |
