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Inventor:
Schmuck; Rainer
Address:
Benediktbeuern, DE
No. of patents:
15
Patents:












Patent Number Title Of Patent Date Issued
8580949 Enzymatic synthesis of carba-NAD November 12, 2013
The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called "carba-NADs", i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic s
8129106 Sequence-specific detection of methylation in biomolecules March 6, 2012
A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whether the recognition
7781196 Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase August 24, 2010
The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the A. calcoaceticus s-GDH wild-type
7732179 Mutants of pyrroloquinoline quinone dependent soluble glucose dehydrogenase June 8, 2010
A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position 348 by either glycine, alamine or serine, wherein said mutant additionally comprises, a
7547535 Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase June 16, 2009
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these
7547524 Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an am June 16, 2009
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known from Acinetobacter calcoaceticus, t
7517664 Inactivated enzyme variants and associated process and reagent system April 14, 2009
The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA s
7348423 Nucleic acids encoding fusion peptides March 25, 2008
A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressin
7172890 Inactivated enzyme variants and associated process and reagent system February 6, 2007
The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA s
7132270 Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase November 7, 2006
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these
6958231 Variants of Erwinia-type creatinase October 25, 2005
The present invention relates to mutated genes encoding variants of an Erwinia-type creatinase (EC 3.5.3.3, alternative name: creatine amidinohydrolase), to the creatinase variants encoded by these genes, and to different applications of these variants of creatinase, particularly to
6905689 Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production June 14, 2005
A conjugate of a tissue non-specific alkaline phosphatase (tns-AP) and dextran which can be obtained by reacting unglycosylated tns-AP with activated dextran by incubation in aqueous solution, stopping the reaction and isolating the conjugate from the solution. The conjugate obtained in
6902920 Method for producing an active heterodimeric AMV-RT in prokaryotic cells June 7, 2005
The heterologous expression of the reverse transcriptase from the Avian Myeloblastosis Virus (AMV-RT) in prokaryotic cells and in particular Escherichia coli (E. coli) is described in the present invention. The invention also includes certain measures to simplify the purification of
6858410 Process for making antifusogenic fusion peptides that form inclusion bodies February 22, 2005
A process is provided for producing an antifusogenic peptide by producing a fusion peptide of from about 14 amino acids up to 70 amino acids in a prokaryotic host cell under conditions in which inclusion bodies are formed. The antifusogenic peptide recovered from the inclusion bodies is
6255093 Recombinant microbial 3-hydroxybutyrate dehydrogenase a process for its production and the use t July 3, 2001
DNA molecule comprising a structural gene which codes for a bacterial protein with the enzymatic activity of 3-hydroxybutyrate dehydrogenase (3-HBDH), a recombinant DNA containing the DNA molecule, microorganisms transformed accordingly, a process for obtaining 3-HBDH by culturing a










 
 
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