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Inventor:
Scharp; David W.
Address:
St. Louis, MO
No. of patents:
13
Patents:












Patent Number Title Of Patent Date Issued
6960351 Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products November 1, 2005
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective,
6322804 Implantable biocompatible immunoisolatory vehicle for the delivery of selected therapeutic produ November 27, 2001
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective,
6083523 Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products July 4, 2000
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective,
5916554 Use of pouch for implantation of living cells June 29, 1999
A biocompatable and biostable flexible pouch for use e.g., in implanting cell bodies producing therapeutic agents, featuring, in various aspects, either encapsulated or unencapsulated cell bodies contained within the pouch; and a means for attaching the opening of the pouch to a vasc
5874099 Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocom February 23, 1999
A method of forming an implantable and retrievable immunoisolatory vehicles is disclosed, the method comprising the steps of first forming a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells capable of providing a biologically active product or metabolic or imm
5871767 Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implan February 16, 1999
A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1 .mu.l and at least 10.sup.4 living cells which secrete at least one biologically active p
5869077 Methods for treating diabetes by delivering insulin from biocompatible cell-containing devices February 9, 1999
A method for treating diabetes in a patient comprising subcutaneously implanting in the patient at least one immunoisolatory vehicle comprising a core comprising a volume of at least 1 .mu.l and at least about 10.sup.4 living cells which secrete insulin, said cells being dispersed in a
5800829 Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a b September 1, 1998
A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to an individual, and an
5800828 Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products September 1, 1998
Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells capable of secreting a biologically active product or of providing a biological function to a patient, the cells dispe
5798113 Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products August 25, 1998
A method of providing a biologically active molecule or metabolic or immunologic function to a patient, comprising implanting into the body of the patient at least one immunoisolatory vehicle comprising a core comprising a volume in excess of 1 .mu.l and at least about 10.sup.4 livin
5322790 Islet isolation process June 21, 1994
A method of producing intact islets of Langerhans in an insulin producing condition uses a mixture of Hank's solution and 10% by volume fetal calf serum to ductally distend the human pancreas. The exocrine tissue of the pancreas is digested at about 37.degree. C. by an enzyme preparation
5079160 Method to isolate clusters of cell subtypes from organs January 7, 1992
A method to obtain purified, well-defined cell populations from intact organs uses digestion of the distended organ with suitable proteolytic enzymes and harvest of the cell subpopulation by screening the effluent from treatment of the organ with physiologically compatible medium by a
4868121 Islet isolation process September 19, 1989
A method of producing intact islets of Langerhans in an insulin producing condition uses a mixture of Hank's solution and 10% by volume fetal calf serum to ductally distend the human pancreas. The exocrine tissue of the pancreas is digested at about 37.degree. C. by an enzyme preparation










 
 
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