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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Sakowicz; Roman
Address:
Foster City, CA
No. of patents:
39
Patents:












Patent Number Title Of Patent Date Issued
7462482 Human smooth muscle myosin heavy chain December 9, 2008
The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
7378254 Compositions and assays utilizing ADP or phosphate for detecting protein modulators May 27, 2008
Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obv
7341845 Method for identifying kinesin inhibitors March 11, 2008
The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The pr
7276331 Plus end-directed microtubule motor required for chromosome congression October 2, 2007
The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
7247473 Motor proteins and methods for their use July 24, 2007
The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.
7214503 Methods for treating congestive heart failure May 8, 2007
The present invention provides high throughput screening methods for characterizing compounds that modulate the biological activity of a biochemically functional sarcomere. Compounds characterized by such methods are useful for treating congestive heart failure.
7202051 Compositions and assays utilizing ADP or phosphate for detecting protein modulators April 10, 2007
Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obv
7009043 Plus end-directed microtubule motor required for chromosome congression March 7, 2006
The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
7005272 Methods for screening and therapeutic applications of kinesin modulators February 28, 2006
The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The pr
6974688 Human smooth muscle myosin heavy chain December 13, 2005
The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
6815169 Identification and expression of a novel kinesin motor protein November 9, 2004
The invention provides isolated nucleic acid and amino acid sequences of TL-.gamma., antibodies to TL-.gamma., methods of screening for TL-.gamma. modulators using biologically active TL-.gamma., and kits for screening for TL-.gamma. modulators.
6777200 Kinesin motor modulators derived from the marine sponge Adocia August 17, 2004
This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vi
6764830 Thermomyces lanuginosus kinesin motor protein and methods of screening for modulators of kinesin July 20, 2004
The invention provides isolated nucleic acid and amino acid sequences of TL-.sub..gamma., antibodies to TL-.sub..gamma., methods of screening for TL-.sub..gamma. modulating using biologically active TL-.sub..gamma., and kits for screening for TL-.sub..gamma. modulators.
6759240 Methods for purifying actin July 6, 2004
Methods for purifying actin are provided. The methods generally involve the addition of a magnesium salt in a sufficient quantity, whereby G-actin polymerizes to form actin paracrystals, which can be recovered as a purified form of actin.
6743599 Compositions and assays utilizing ADP or phosphate for detecting protein modulators June 1, 2004
Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obv
6723840 Identification and expression of a novel kinesin motor protein April 20, 2004
The invention provides isolated nucleic acid and amino acid sequences of TL-.gamma., antibodies to TL-.gamma., methods of screening for TL-.gamma. modulators using biologically active TL-.gamma., and kits for screening for TL-.gamma. modulators.
6680369 Motor proteins and methods for their use January 20, 2004
The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.
6645748 Plus end-directed microtubule motor required for chromosome congression November 11, 2003
The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.
6638754 Motor proteins and methods for their use October 28, 2003
The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6627408 Antifungal assay September 30, 2003
The present invention provides high throughput screening Systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6617115 Methods of screening for modulators of cell proliferation September 9, 2003
Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (ge
6613540 Methods for screening and therapeutic applications of kinesin modulators September 2, 2003
The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The pr
6573061 Sarcomere protein composition June 3, 2003
The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6544766 Human kinesins and methods of producing and purifying human kinesins April 8, 2003
Described herein are methods of producing kinesins. In a preferred embodiment, the kinesins are produced from a prokaryote, most preferably, a bacterial cell. Bacterial expression offers several advantages over systems previously utilized, such as, for example, Bacculovirus. The yield
6509167 High throughput sarcomeric assay January 21, 2003
The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6495337 High throughput sarcomeric assay December 17, 2002
The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6489134 Kinesin motor modulators derived from the marine sponge Adocia December 3, 2002
This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vi
6468760 Antifungal assay October 22, 2002
The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6440686 Methods for screening and therapeutic applications of kinesin modulators August 27, 2002
The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The pr
6440684 Methods of identifying modulators of kinesin motor proteins August 27, 2002
The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6437115 Nucleic acids encoding KSP, a kinesin motor protein August 20, 2002
Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (ge
6414121 Human kinesin protein KSP July 2, 2002
Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (ge
6410254 Compositions and assays utilizing ADP or phosphate for detecting protein modulators June 25, 2002
Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obv
6391613 Motor proteins and methods for their use May 21, 2002
The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.
6379912 Motor proteins and method for their use April 30, 2002
The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.
6355466 Motor proteins and methods for their use March 12, 2002
The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.
6331424 Motor proteins and methods for their use December 18, 2001
The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6284480 Antifungal assay September 4, 2001
The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
6207403 Kinesin motor modulators derived from the marine sponge Adocia March 27, 2001
This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vi










 
 
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