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Inventor:
Rose; Samuel J.
Address:
Los Altos, CA
No. of patents:
8
Patents:












Patent Number Title Of Patent Date Issued
6368803 Detection of nucleic acids by target-catalyzed formation April 9, 2002
A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of a 5'-nuclease under isotherm
6121001 Detection of nucleic acids by target-catalyzed product formation September 19, 2000
A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of a 5'-nuclease under isotherm
6110677 Oligonucleotide modification, signal amplification, and nucleic acid detection by target-catalyz August 29, 2000
A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of a 5'-nuclease under isotherm
5914230 Homogeneous amplification and detection of nucleic acids June 22, 1999
The present invention relates to a method for detecting or amplifying and detecting a target polynucleotide sequence. The method comprises providing in combination (i) a medium suspected of containing the target polynucleotide sequence, (ii) all reagents required for conducting an am
5882867 Detection of nucleic acids by formation of template-dependent product March 16, 1999
A method is disclosed for detecting a target polynucleotide sequence. The method comprises incubating an oligonucleotide with the target polynucleotide sequence and a nucleotide polymerase under isothermal conditions wherein at least one nucleotide is added to the 3'-terminus of the
5882857 Internal positive controls for nucleic acid amplification March 16, 1999
The present invention relates to an improvement in a method for amplifying a target sequence of a target polynucleotide. The method comprises combining a sample suspected of containing the target polynucleotide with reagents for amplifying the target sequence and subjecting the combinati
5792614 Detection of nucleic acids by target-catalyzed product formation August 11, 1998
A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of a 5'-nuclease under isotherm
5605796 Method for preventing amplification of nucleic acid contaminants in amplification mixtures using February 25, 1997
Methods and kits are disclosed for preventing amplification of contaminating copies of nucleic acids during in amplification of a nucleic acid suspected of being present in a sample. Modified nucleotides that render copies of the nucleic acid bindable by a member of a specific bindin










 
 
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