| Patent Number |
Title Of Patent |
Date Issued |
| 7176256 |
Biocompatible crosslinked composition |
February 13, 2007 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 7151135 |
Crosslinked polymer compositions |
December 19, 2006 |
| Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a |
| 7129209 |
Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions |
October 31, 2006 |
| The present invention discloses novel crosslinked biomaterial compositions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bis(sul |
| 6969400 |
Synthetic implant with nonimmunogenicity coating |
November 29, 2005 |
| Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a |
| 6962979 |
Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agent |
November 8, 2005 |
| The present invention discloses novel crosslinked biomaterial compsotions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bix(sulf |
| 6911496 |
Composition for administration of a biologically active compound |
June 28, 2005 |
| Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a |
| 6624245 |
Rapid-gelling biocompatible polymer composition and associated methods of preparation and use |
September 23, 2003 |
| A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i.e., at a selected site within a patient's body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein m.gtoreq.2 and a biocompatible |
| 6534591 |
Cross-linked polymer compositions and methods for their use |
March 18, 2003 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 6323278 |
Method of making crosslinked polymer matrices in tissue treatment applications |
November 27, 2001 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 6312725 |
Rapid gelling biocompatible polymer composition |
November 6, 2001 |
| This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired |
| 6166130 |
Method of using crosslinked polymer compositions in tissue treatment applications |
December 26, 2000 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 6165489 |
Crosslinked collagen compositions for in situ administration |
December 26, 2000 |
| The present invention discloses a novel, injectable crosslinked collagen composition which is able to continue crosslinking after injection to a soft or hard tissue site in order to anchor the collagen implant to the host tissue. The composition comprises particulate crosslinked collagen |
| 6051648 |
Crosslinked polymer compositions and methods for their use |
April 18, 2000 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 5936035 |
Biocompatible adhesive compositions |
August 10, 1999 |
| Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred comp |
| 5874500 |
Crosslinked polymer compositions and methods for their use |
February 23, 1999 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 5800541 |
Collagen-synthetic polymer matrices prepared using a multiple step reaction |
September 1, 1998 |
| The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer |
| 5786421 |
Method of preventing formation of adhesions following surgery |
July 28, 1998 |
| Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred comp |
| 5752974 |
Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
May 19, 1998 |
| Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, |
| 5744545 |
Biocompatible adhesive compositions |
April 28, 1998 |
| Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred comp |
| 5643464 |
Process for preparing a sterile, dry crosslinking agent |
July 1, 1997 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5614587 |
Collagen-based bioadhesive compositions |
March 25, 1997 |
| Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred comp |
| 5580923 |
Anti-adhesion films and compositions for medical use |
December 3, 1996 |
| Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of |
| 5565519 |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications |
October 15, 1996 |
| Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in |
| 5550187 |
Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
August 27, 1996 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5527856 |
Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
June 18, 1996 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5510418 |
Glycosaminoglycan-synthetic polymer conjugates |
April 23, 1996 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5510121 |
Glycosaminoglycan-synthetic polymer conjugates |
April 23, 1996 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5476666 |
Glycosaminoglycan-synthetic polymer conjugates |
December 19, 1995 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5475052 |
Collagen-synthetic polymer matrices prepared using a multiple step reaction |
December 12, 1995 |
| The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer |
| 5470911 |
Glycosaminoglycan-synthetic polymer conjugates |
November 28, 1995 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
