| Patent Number |
Title Of Patent |
Date Issued |
| 7582280 |
Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic ap |
September 1, 2009 |
| The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radio |
| 7399460 |
Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
July 15, 2008 |
| Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chel |
| 7351389 |
Aminocarboxylate ligands having substituted aromatic amide moieties |
April 1, 2008 |
| Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula ##STR00001## wherein R.sub.13, A.sub.1, R.sub.1 and R.sub.2 are as defined herein, are disclosed. |
| 7186397 |
Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
March 6, 2007 |
| Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chel |
| 7160535 |
Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic ap |
January 9, 2007 |
| The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radio |
| 6875864 |
Aminocarboxylate ligands having substituted aromatic amide moieties |
April 5, 2005 |
| Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula ##STR1##wherein R.sub.13, A.sub.1, R.sub.1 and R.sub.2 are as defined herein, are disclosed. |
| 6693190 |
Enhanced relaxivity monomeric and multimeric compounds |
February 17, 2004 |
| Metal chelates capable of exhibiting an immobilized relativity between about 60 and 200 mM.sup.-1 s.sup.-1 /metal atom are useful as magnetic resonance imaging agents. Additionally, a compound which is useful as a metal-chelating ligand has the following formula: ##STR1##wherein Q |
| 6509324 |
Chelating compounds, their complexes with paramagnetic metals |
January 21, 2003 |
| Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging. |
| 6221334 |
Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
April 24, 2001 |
| Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated |
| 6093382 |
Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
July 25, 2000 |
| Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated |
| 5869024 |
Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formatio |
February 9, 1999 |
| In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present method comprises employing a triiodina |
| 5628980 |
Nonionic radiographic contrast agents |
May 13, 1997 |
| New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, ##STR2## --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-- or ##STR3## R.sub.1, R.sub.1 ' and R.sub.2 are the |
| 5614638 |
Nonionic radiographic contrast agents |
March 25, 1997 |
| New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, ##STR2## --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-- or ##STR3## R.sub.1, R.sub.1 ' and R.sub.2 are the |
| 5591846 |
Nonionic radiographic contrast agents |
January 7, 1997 |
| New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, ##STR2## R.sub.1, R.sub.1 ' and R.sub.2 are the same or different and are hydrogen, alkyl or hydroxyalkyl.Hydroxyalkyl refers to such alkyl groups having 1 or more hydroxy groups. |
| 5573752 |
Aromatic amide compounds and metal chelates thereof |
November 12, 1996 |
| Novel aromatic amide compounds comprising a ligand nucleus containing at least one aminocarboxylate, aminophosphonate and/or aminohydroxamate chelating group, substituted with a substituted aromatic amide group of the formula ##STR1## wherein R is ##STR2## or --[(CH.sub.2 |
| 5559237 |
Process for preparation of 2-oxo-1-piperidinyl derivatives |
September 24, 1996 |
| The present process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2## |
| 5527926 |
Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formatio |
June 18, 1996 |
| In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present method comprises employing a triiodina |
| 5359077 |
Process for preparation of 2-oxo-1 piperidinyl derivatives |
October 25, 1994 |
| The process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl group ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2## |
