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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Ranganathan; Ramachandran S.
Address:
Princeton, NJ
No. of patents:
18
Patents:












Patent Number Title Of Patent Date Issued
7582280 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic ap September 1, 2009
The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radio
7399460 Metal complexes derivatized with folate for use in diagnostic and therapeutic applications July 15, 2008
Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chel
7351389 Aminocarboxylate ligands having substituted aromatic amide moieties April 1, 2008
Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula ##STR00001## wherein R.sub.13, A.sub.1, R.sub.1 and R.sub.2 are as defined herein, are disclosed.
7186397 Metal complexes derivatized with folate for use in diagnostic and therapeutic applications March 6, 2007
Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chel
7160535 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic ap January 9, 2007
The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radio
6875864 Aminocarboxylate ligands having substituted aromatic amide moieties April 5, 2005
Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula ##STR1##wherein R.sub.13, A.sub.1, R.sub.1 and R.sub.2 are as defined herein, are disclosed.
6693190 Enhanced relaxivity monomeric and multimeric compounds February 17, 2004
Metal chelates capable of exhibiting an immobilized relativity between about 60 and 200 mM.sup.-1 s.sup.-1 /metal atom are useful as magnetic resonance imaging agents. Additionally, a compound which is useful as a metal-chelating ligand has the following formula: ##STR1##wherein Q
6509324 Chelating compounds, their complexes with paramagnetic metals January 21, 2003
Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.
6221334 Metal complexes derivatized with folate for use in diagnostic and therapeutic applications April 24, 2001
Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated
6093382 Metal complexes derivatized with folate for use in diagnostic and therapeutic applications July 25, 2000
Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated
5869024 Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formatio February 9, 1999
In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present method comprises employing a triiodina
5628980 Nonionic radiographic contrast agents May 13, 1997
New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, ##STR2## --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-- or ##STR3## R.sub.1, R.sub.1 ' and R.sub.2 are the
5614638 Nonionic radiographic contrast agents March 25, 1997
New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, ##STR2## --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-- or ##STR3## R.sub.1, R.sub.1 ' and R.sub.2 are the
5591846 Nonionic radiographic contrast agents January 7, 1997
New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, ##STR2## R.sub.1, R.sub.1 ' and R.sub.2 are the same or different and are hydrogen, alkyl or hydroxyalkyl.Hydroxyalkyl refers to such alkyl groups having 1 or more hydroxy groups.
5573752 Aromatic amide compounds and metal chelates thereof November 12, 1996
Novel aromatic amide compounds comprising a ligand nucleus containing at least one aminocarboxylate, aminophosphonate and/or aminohydroxamate chelating group, substituted with a substituted aromatic amide group of the formula ##STR1## wherein R is ##STR2## or --[(CH.sub.2
5559237 Process for preparation of 2-oxo-1-piperidinyl derivatives September 24, 1996
The present process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2##
5527926 Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formatio June 18, 1996
In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel compositions for such method are also disclosed. The present method comprises employing a triiodina
5359077 Process for preparation of 2-oxo-1 piperidinyl derivatives October 25, 1994
The process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl group ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2##










 
 
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