| Patent Number |
Title Of Patent |
Date Issued |
| 7608274 |
Therapeutic processes and useful compositions therefor |
October 27, 2009 |
| This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cance |
| 7569695 |
Dyes for the detection or quantification of desirable target molecules |
August 4, 2009 |
| The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target |
| 7553959 |
Fluorescent dye composition and target labeled therewith |
June 30, 2009 |
| This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or |
| 7547772 |
Chimeric nucleic acid constructs and compositions comprising sets of nucleic acid constructs |
June 16, 2009 |
| This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. |
| 7537751 |
Labeling reagents and labeled targets comprising nonmetallic porphyrins |
May 26, 2009 |
| This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or |
| 7514551 |
Multisignal labeling reagents, and processes and uses therefor |
April 7, 2009 |
| The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in detecting or amplifying analyte-specific moieties. |
| 7494806 |
Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences |
February 24, 2009 |
| Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include o |
| 7485417 |
Post-termination labeling of nucleic acid fragments and uses thereof |
February 3, 2009 |
| This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. In non-linear ampli |
| 7468245 |
Methods for detecting nucleic acid sequences |
December 23, 2008 |
| This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. In non-linear ampli |
| 7439060 |
Independent helper virus packaging cell line for propagating viral vectors |
October 21, 2008 |
| Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include o |
| 7396647 |
Site- or sequence-specific process for cleaving analytes and library of analytes |
July 8, 2008 |
| This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. |
| 7264930 |
Processes for non-linearly amplifying nucleic acids |
September 4, 2007 |
| This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. In non-linear ampli |
| 7256299 |
Chemiluminescent reagents |
August 14, 2007 |
| This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or |
| 7256291 |
Labeling reagents comprising aphenylic analogs of rhodamine dyes |
August 14, 2007 |
| This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or |
| 7220854 |
Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions compris |
May 22, 2007 |
| The present invention provides a nucleotide having the formula, ##STR00001## wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to SM at a position independently selected from the 2 |
| 7166478 |
Labeling reagents and labeled targets, target labeling processes and other processes for using s |
January 23, 2007 |
| This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or |
| 7163796 |
Process for detecting the presence or quantity of enzymatic activity in a sample |
January 16, 2007 |
| This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or |
| 7064197 |
System, array and non-porous solid support comprising fixed or immobilized nucleic acids |
June 20, 2006 |
| Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions are useful for nucleic acid analyses and a host of applications, including, for exampl |
| 6992180 |
Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides |
January 31, 2006 |
| The present invention provides a nucleotide having the formula, Sig-PM-SM-BASE wherein PM is a phosphate moiety, SM is a sugar moiety and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to the 3' or the 5' position of the sugar moiety when the nucleotide is a deo |
| 6986985 |
Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construc |
January 17, 2006 |
| This invention provides in vitro processes for producing copies of specific nucleic acids using protein-nucleic acid constructs which are part of conjugates which are introduced into cells. Illustrative of the elements useful in these constructs for producing copies of specific nucle |
| 6949659 |
Dye labeling composition |
September 27, 2005 |
| This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or |
| 6764821 |
Detecting the presence of specific target nucleic acid sequences through stem-loop formation |
July 20, 2004 |
| This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. In nonlinear amplif |
| 6743605 |
Linear amplification of specific nucleic acid sequences |
June 1, 2004 |
| This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. In non-linear ampli |
| 6566068 |
Process for detecting a nucleic acid of interest using an oligo- or polynucleotide probe and int |
May 20, 2003 |
| Disclosed is a nucleic acid hybridization assay composition for detecting the presence or absence of a target oligo- or polynucleotide in a sample. The composition comprises: a solid matrix having at least one surface which is substituted with a first intercalator capable of binding dsDN |
| 6239271 |
Energy transfer hybridization assay composition |
May 29, 2001 |
| Disclosed is a nucleic acid hybridization assay composition for detecting the presence or absence of a target oligo- or polynucleotide in a sample. The composition comprises: a solid matrix having at least one surface which is substituted with a first intercalator capable of binding dsDN |
| 6221581 |
Processes for detecting polynucleotides, determining genetic mutations or defects in genetic mat |
April 24, 2001 |
| Double hybrid or multihybrid probes and compositions are usefully combined with capture assay and immobilization to provide for detection processes in which target polynucleotides can be detected or the presence or absence of genetic mutations or defects in genetic material can be determ |
| 5998135 |
Energy transfer hybridization assay using intercalators and lanthanide metals |
December 7, 1999 |
| Disclosed is a nucleic acid hybridization assay composition for detecting the presence of absence of a target oligo- or polynucleotide in a sample. The composition comprises: a solid matrix having at least one surface which is substituted with a first intercalator capable of binding dsDN |
| 5288609 |
Capture sandwich hybridization method and composition |
February 22, 1994 |
| This invention provides methods and compositions for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods and compositions for the detection of mutants. The methods and compositions are based in part upon techniques which utilize |
| 5260433 |
Saccharide specific binding system labeled nucleotides |
November 9, 1993 |
| The present invention provides nucleotides and polynucleotides which are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material. More particularly, this invention provides a nucleotide selected from the group |
| 5241060 |
Base moiety-labeled detectable nucleatide |
August 31, 1993 |
| The present invention provides nucleotides and polynucleotides which are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material. More particularly, this invention provides a nucleotide having the formulawherein |
| 4894325 |
Hybridization method for the detection of genetic material |
January 16, 1990 |
| This invention provides methods for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods for the detection of mutations. Also provided are components for use in such methods.The methods are based upon techniques which utilize two l |
| 4889798 |
Heterologous system for the detection of chemically labeled DNA and other biological materials p |
December 26, 1989 |
| In accordance with the practices of this invention, there is provided a heterologous detection system and components useful in conjunction therewith and kits for carrying out the heterologous detection system. The heterologous detection system employs a heterologous entity and a sign |
| 4868103 |
Analyte detection by means of energy transfer |
September 19, 1989 |
| A method is disclosed to detect the presence of an analyte. The method involves forming a complex comprising the analyte and a binding entity. The binding entity comprises a first partner of an energy transfer system. The complex is then contacted with a reporting entity to form a unit. |
| 4755458 |
Composition and method for the detection of the presence of a polynucleotide sequence of interes |
July 5, 1988 |
| The present invention relates to a wide range of genetic analyses using the technique of nucleic acid hybridization. These genetic analyses include, for example, the diagnosis of infections by foreign microbes and the detection of specific genetic traits and abnormalities. More specifica |
