| Patent Number |
Title Of Patent |
Date Issued |
| 7196118 |
Amidino compounds useful as nitric oxide synthase inhibitors |
March 27, 2007 |
| The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides |
| 7102013 |
Methods of making amidino compounds useful as nitric oxide synthase inhibitors |
September 5, 2006 |
| Method of making an alpha-amino acid compound having the structure of Formula 32: ##STR00001## comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: ##STR00002## where the substituents are described herein. |
| 7005450 |
2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibit |
February 28, 2006 |
| The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. |
| 6956131 |
2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors |
October 18, 2005 |
| The present invention is directed to a compound of formula I: ##STR1##or a pharmaceutically acceptable salt thereof, wherein: R.sub.2 is selected from the group consisting of H and methyl; and R.sub.2 is selected from the group consisting of H and methyl.The compounds possess useful nitric |
| 6951889 |
2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhib |
October 4, 2005 |
| The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. |
| 6914158 |
Amidino compounds useful as nitric oxide synthase inhibitors |
July 5, 2005 |
| The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides |
| 6787668 |
2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
September 7, 2004 |
| The present invention is directed to a compound of formula I: ##STR1##or a pharmaceutically acceptable salt thereof, wherein:R.sub.1 is selected from the group consisting of H and methyl; andR.sub.2 is selected from the group consisting of H and methyl.The compounds possess useful nitric oxide s |
| 6756406 |
2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibit |
June 29, 2004 |
| The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. |
| 6586474 |
Amidino compounds useful as nitric oxide synthase inhibitors |
July 1, 2003 |
| The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides |
| 6586471 |
Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
July 1, 2003 |
| The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors. |
| 6576780 |
Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
June 10, 2003 |
| The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors. |
| 6552052 |
Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide |
April 22, 2003 |
| Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: ##STR1##or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein. |
| 6545170 |
2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
April 8, 2003 |
| The present invention contains novel compounds useful as nitric oxide synthase inhibitors. |
| 6489323 |
Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
December 3, 2002 |
| The current invention relates to compounds of Formula I ##STR1##pharmaceutical compositions and methods of use as nitric oxide synthase inhibitors, wherein the substituents are defined in the application. |
| 6465686 |
Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
October 15, 2002 |
| The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors. |
| 6448286 |
Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors |
September 10, 2002 |
| The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors. |
| 6403830 |
Amidino compound and salts thereof useful as nitric oxide synthase inhibitors |
June 11, 2002 |
| The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof. |
| 6344483 |
Halogenated amidino amino acid deviratives useful as nitric oxide synthase inhibitors |
February 5, 2002 |
| The current invention discloses halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors, and pharmaceutically acceptable salts thereof. |
| 6344473 |
Imidazoles useful as nitric oxide synthase inhibitors |
February 5, 2002 |
| 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors. |
| 6207708 |
Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
March 27, 2001 |
| The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors. |
| 6143790 |
L-N.sup.6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors |
November 7, 2000 |
| There is disclosed a novel amino glycol derivatives of L-N.sup.6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors. |
| 6136829 |
Oxathiadiazole derivatives usful as iNOS inhibitors |
October 24, 2000 |
| 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors. |
| 6114381 |
Non-heterocyclic .beta.-phenyl-.alpha.-aminopropionic acid n-phenyl amides for treatment of neur |
September 5, 2000 |
| Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a .beta.-phenyl-.alpha.-aminopropionic acid N phenyl |
| 6071906 |
Imidino piperidine derivatives useful as nitric oxide synthase inhibitors |
June 6, 2000 |
| The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors. |
| 6046211 |
Amidino derivatives useful as nitric oxide synthase inhibitors |
April 4, 2000 |
| The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors. |
| 6043261 |
Pyrrolodino imidines useful as nitric oxide synthase inhibitors |
March 28, 2000 |
| The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors. |
| 6011028 |
Cyclic amidino agents useful as nitric oxide synthase inhibitors |
January 4, 2000 |
| The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors. |
| 5981556 |
1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
November 9, 1999 |
| 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors. |
| 5981511 |
Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
November 9, 1999 |
| The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors. |
| 5958958 |
1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibi |
September 28, 1999 |
| 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors. |
| 5883251 |
Azepine derivatives useful as nitric oxide synthase inhibitors |
March 16, 1999 |
| The current invention discloses azepine derivatives useful as nitric oxide synthase inhibitors. |
| 5854234 |
Amidino dervatives useful as nitric oxide synthase inhibitors |
December 29, 1998 |
| The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors. |
| 5631399 |
Process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]a |
May 20, 1997 |
| The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof. |
| 5536869 |
Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]am |
July 16, 1996 |
| The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof which comprises treating (trimethylsilyl)acetylene sequentially with |
| 5504077 |
Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical composition |
April 2, 1996 |
| The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in |
| 5449675 |
Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and |
September 12, 1995 |
| The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in |
| 5449674 |
2-,3-,5-, and/or 8-substituted dibenzoxazepine compounds, pharmaceutical compositions and method |
September 12, 1995 |
| The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a |
| 5441950 |
Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical composition |
August 15, 1995 |
| The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in |
| 5436249 |
Opioid agonist compounds |
July 25, 1995 |
| The present invention provides novel substituted opioid analgesic compounds of Formula I: ##STR1## which are opioid agonists, and which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compoun |
| 5395932 |
2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositi |
March 7, 1995 |
| The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## wherein X is oxygen, sulfur ##STR2## A is --CH.sub.2 -- or ##STR3## E and F may be --CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; w |
| 5354863 |
Opioid agonist compounds |
October 11, 1994 |
| The present invention provides novel substituted opioid analgesic compounds of Formula I: ##STR1## which are opioid agonists, and which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compoun |
| 5354746 |
Squaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions a |
October 11, 1994 |
| The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E.sub.2 antagonists for the treatment of prostaglandin-E.sub.2 mediated diseases, pharmaceutical compos |
| 5225417 |
Opioid agonist compounds |
July 6, 1993 |
| The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are opioid agonists which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula |
| 5223507 |
Method of using opioid compounds as delta opioid selective agonist analgesics |
June 29, 1993 |
| The present invention provides a method for eliminating or ameliorating pain in an animal comprising administrating a therapeutically-effective amount of a substituted morphinoid compound of Formula I: ##STR1## The compounds are opioid agonists which are useful as analgesic agents fo |
| 4933369 |
Dimethyl tyrosyl amide sulfides, sulfoxides and sulfones |
June 12, 1990 |
| The present invention relates to new compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof and the enantiomers thereof, wherein R.sup.1 is H, lower alkyl, alkenyl, aralkyl, or C(O)R.sup.2 wherein R.sup.2 is lower alkyl, alkenyl, alkoxy, or aralkyl; n |
| 4933325 |
Pyridyl and pyrimidinyl substituted tyrosyl dipeptide amides |
June 12, 1990 |
| The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, --OCO.sub.2 lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n -phen |
| 4880829 |
Substituted dipeptide amides #3 |
November 14, 1989 |
| The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, --OCO.sub.2 lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n --phe |
| 4822775 |
Phenyl substituted dipeptide amides |
April 18, 1989 |
| The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, --OCO.sub.2 lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n -phen |
| 4797470 |
O-substituted tyrosyl dipeptide amides |
January 10, 1989 |
| This invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is ##STR2## where X is oxygen or sulfur, Y is oxygen or nitrogen, and R.sup.11 represents straight or branched chain lower alkenyl havi |
| 4760180 |
N-terminally substituted dipeptide amides |
July 26, 1988 |
| This invention encompasses compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is lower alkoxy or --O--(CH.sub.2).sub.n -phenyl where the phenyl may be optionally substituted with halogen, --NO.sub.2, --CN, --NH.sub.2 |
