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Inventor:
Ostuni; Emanuele
Address:
Watertown, MA
No. of patents:
16
Patents:












Patent Number Title Of Patent Date Issued
7419823 Device and method for monitoring leukocyte migration September 2, 2008
A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further
7374906 Biological assays using gradients formed in microfluidic systems May 20, 2008
The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradien
7364899 Device for monitoring haptotaxis April 29, 2008
The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first well configured to receive a test agent therein and further including biomolecules immobi
7288394 Selective deposition of materials on countoured surfaces October 30, 2007
A method of patterning materials, such as proteins, on a contoured surface by depositing them onto protrusions on a surface, and a cell containment device that may be constructed by this method, are provided. The method may involve selectively depositing a material on a substrate includi
7211209 Method of making device for arraying biomolecules and for monitoring cell motility in real-time May 1, 2007
The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in flui
7169578 Cell isolation and screening device and method of using same January 30, 2007
The present invention provides methods and devices for screening a single cell or a small group of cells for a desired biological activity. In particular, the present invention provides for delivering cell(s) to a plurality of cell isolation regions of a cell isolation device, transf
7169577 Cell isolation and screening device and method of using same January 30, 2007
The present invention provides methods and devices for screening a single cell or a small group of cells for a desired biological activity. In particular, the present invention provides for delivering cell(s) to a plurality of cell isolation regions of a cell isolation device, transf
7123764 Image processing method for use in analyzing data of a chemotaxis or haptotaxis assay October 17, 2006
An image processing method for use in analyzing image data of a cellular migration assay. The method includes defining a major axis within the image data that is perpendicular to an orientation of channels in the image data, determining an aggregate light intensity within the image d
7033819 System for monitoring cell motility in real-time April 25, 2006
The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in flui
6982171 Cell motility and chemotaxis test device and methods of using same January 3, 2006
The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The
6921660 Cell motility and chemotaxis test device and methods of using same July 26, 2005
The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The
6893851 Method for arraying biomolecules and for monitoring cell motility in real-time May 17, 2005
The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in flui
6864065 Assays for monitoring cell motility in real-time March 8, 2005
The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in flui
6844184 Device for arraying biomolecules and for monitoring cell motility in real-time January 18, 2005
The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in flui
6818403 Method of monitoring haptotaxis November 16, 2004
The present invention discloses a method of monitoring haptotaxis comprising: providing a device for monitoring haptotaxis having a housing defining a chamber. The chamber includes: a first well region including at least one first well, the first well region configured to receive a test
6811968 Method of monitoring cell motility and chemotaxis November 2, 2004
The present invention discloses a method of monitoring chemotaxis or chemoinvasion comprising: providing a device for monitoring chemotaxis. The device includes a support member; a top member mounted to the support member by being placed in substantially fluid-tight, conformal contact










 
 
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