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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Ondetti; Miguel A.
Address:
Princeton, NJ
No. of patents:
85
Patents:


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Patent Number Title Of Patent Date Issued
5212165 Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through athe May 18, 1993
A method is provided for rehabilitating or restoring the vasorelaxant action of the endothelium impaired by atherosclerosis and/or hypercholesterolemia, thereby preventing arteriospasm in the coronary arteries using an angiotensin converting enzyme inhibitor such as captopril, fosino
5166143 Method for preventing onset of restenosis after angioplasty employing an ace inhibitor November 24, 1992
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after angioplasty.
5140012 Method for preventing onset of restenosis after angioplasty employing pravastatin August 18, 1992
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering pravastatin alone or in combination with an ACE inhibitor such as captopril or ceranapril, prior to, during and/or after angioplasty.
5061694 Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing a October 29, 1991
A method is provided for slowing the progression of atherosclerosis in coronary arteries in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients in a mammalian species by administering an ACE inhibitor, especially one containing a
4798904 Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or January 17, 1989
Acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
4774256 Use of enkephalinase inhibitors as analgesic agents September 27, 1988
Mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
4722810 Enkephalinase inhibitors February 2, 1988
Mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
4611002 Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors September 9, 1986
New carboxymethyl esters of mercaptopropanoic acids, and salts thereof, have the formula ##STR1## wherein R is hydrogen or lower alkanoyl;R.sub.1 is hydrogen, lower alkyl, phenylalkyl and phenyl;R.sub.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, 4-hydroxyphenyl-lower alkyl
4533660 Antibacterial O-sulfated .beta.-lactam hydroxamic acids August 6, 1985
Antibacterial activity is exhibited by .beta.-lactams having a sulfate substituent in the 1-position and an acylamino substituent in the 3-position.
4482725 S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics November 13, 1984
The S-acylation of a mercaptoacyl amino acid having ACE inhibitory action with a diuretic containing a carboxyl group yields a product having both ACE inhibitory action and diuretic activity in vivo.
4377701 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid March 22, 1983
Compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is a readily hydrolyzable acyl protecting group;R.sub.2 is hydrogen or alkyl;R.sub.3 is hydrogen, alkyl or arylalkyl;n is 1 or 2; andp is 1 or 2inhibit the action of angiotensin converting enzyme.
4339600 Compounds for alleviating angiotensin related hypertension July 13, 1982
Compounds for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprising angiotensin converting enzyme inhibitors selected from a group of mercaptoacyl aminoacids.
4337197 O-sulfated .beta.-lactam hydroxamic acids and intermediates June 29, 1982
Antibacterial activity is exhibited by .beta.-lactams having a sulfate substituent in the 1-position and an acylamino substituent in the 3-position.
4330548 Mercaptoacyl derivatives of keto substituted pipecolic acid May 18, 1982
This invention is directed to compounds of the formula ##STR1## which are useful in the treatment of hypertension.
4325945 Mixed disulfides April 20, 1982
This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
4325944 Mixed disulfides April 20, 1982
This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
4325943 Mixed disulfides April 20, 1982
This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
4321392 Mercaptoacyl derivatives of 4-oxazolidine-carboxylic acids March 23, 1982
This invention is directed to compounds of the formula ##STR1## which are useful as hypotensive agents.
4316906 Mercaptoacyl derivatives of substituted prolines February 23, 1982
New mercaptoacyl derivatives of substituted prolines which have the general formula ##STR1## are useful as hypotensive agents.
4313948 Hypotensive imidazole substituted mercapto-1-oxopropyl-L-prolines February 2, 1982
The invention relates to new compounds useful as hypotensive agents, of the formula: ##STR1## wherein R is hydrogen or lower alkyl;R.sub.1 is hydrogen, lower alkyl or halo substituted lower alkyl;R.sub.2 is hydrogen, ##STR2## or ##STR3## R.sub.3 is lower alkyl, phenyl or
4311705 Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines January 19, 1982
Compounds, compositions and method of alleviating hypertension using a compound of the formula ##STR1## wherein R is hydrogen or lower alkyl;R.sub.1 is hydrogen, lower alkyl or phenyl-lower alkyl;R.sub.2 is hydrogen, lower alkyl or phenyl lower alkyl or halo substituted lower alkyl;R
4308392 Hydroxamic acid derivatives of mercaptoacyl amino acids December 29, 1981
Hydroxamic acid derivatives of certain mercaptoacyl amino acids inhibit the conversion of angiotensin I to angiotensin II in mammals and are useful for the treatment of hypertension.
4307110 Mercaptoacyl derivatives of 3-substituted proline derivatives December 22, 1981
New mercaptoacyl derivatives of 3-substituted proline derivatives are provided which have the general formula ##STR1## and are useful as hypotensive agents.
4296113 Mercaptoacyl derivatives of keto substituted proline and pipecolic acid October 20, 1981
This invention is directed to compounds of the formula ##STR1## which are useful in the treatment of hypertension.
4293481 Tripeptide inhibitors of angiotensin-converting enzyme October 6, 1981
Peptides having the formula ##STR1## wherein R.sub.1 is hydrogen and R.sub.2 is hydroxyl, alkyl, aryl, arylalkyl, alkoxy, alkylthio, aryloxy, arylthio, halogen or azido, or R.sub.1 and R.sub.2 are the same and each is hydrogen, halogen, alkoxy or alkylthio, or R.sub.1 and R.sub.2
4284780 Amino acid derivatives August 18, 1981
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4284779 Amino acid derivatives August 18, 1981
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4284624 Mixed disulfides August 18, 1981
This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is and .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
4284561 Hydroxamic acid derivatives of mercaptoacyl amino acids August 18, 1981
Hydroxamic acid derivatives of certain mercaptoacyl amino acids inhibit the conversion of angiotensin I to angiotensin II in mammals and are useful for the treatment of hypertension.
4282235 Derivatives of thiazolidinecarboxylic acids and related acids August 4, 1981
New substituted derivatives of thiazolidine-, thiazane and related carboxylic acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4242265 Indolylalkyl esters of mercaptoalkanoic acids December 30, 1980
New indolylalkyl esters of mercaptoalkanoic acids, and salts thereof, which have the general formula ##STR1## are useful as hypotensive agents.
4241076 Halogenated substituted mercaptoacylamino acids December 23, 1980
New halogen substituted mercaptoacylamino acids which have the general formula ##STR1## and basic salts thereof are useful as hypotensive agents.
4237134 Derivatives of thiazolidinecarboxylic acids and related acids December 2, 1980
New substituted derivatives of thiazolidine-, thiazane- and related carboxylic acids which have the general formula ##STR1## are useful as angiostensin converting enzyme inhibitors.
4237129 Derivatives of thiazolidinecarboxylic acids and related acids December 2, 1980
New substituted derivatives of thiazolidine-, thiazane- and related carboxylic acids which have the general formula ##STR1## are useful as angiostensin converting enzyme inhibitors.
4234489 Pyroglutamic acid derivatives and analogs November 18, 1980
Pyroglutamic acid derivatives and analogs having the formula ##STR1## and salts thereof, wherein R is hydrogen, alkyl or diphenylmethyl;R.sub.1 is hydrogen, alkyl or trifluoromethyl;R.sub.2 is hydrogen, ##STR2## or ##STR3## R.sub.3 is hydrogen, alkyl, phenyl, or phenylalkyl;
4228184 Carboxyalkylacylamino acids October 14, 1980
New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4228077 N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes October 14, 1980
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors. The compounds claimed in this application are those wherein B is indolyl-lower alkylene.
4225495 Pyrrolo or pyrido [2,1-c][1,4] thiazines or thiazepines September 30, 1980
Compounds having the formula ##STR1## wherein R is hydrogen or alkyl, n is 0 or 1 and m is 1 or 2 have hypotensive activity. Those compounds of the above formula wherein n is 1 are useful intermediates for the preparation of other hypotensive agents having the formula ##STR2#
4221912 Dithio derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2 September 9, 1980
New mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids having the general formula ##STR1## are useful as hypotensive agents.
4217458 Acylmercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydro August 12, 1980
New acylmercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids having the general formula ##STR1## are useful as hypotensive agents.
4207342 Relieving hypertension with carboxyalkylacylamino acids June 10, 1980
New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4207337 Relieving hypertension with carboxyalkylacylamino acids June 10, 1980
New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4207336 Relieving hypertension with carboxyalkylacylamino acids June 10, 1980
New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4206232 Relieving hypertension with carboxyalkylacylamino acids June 3, 1980
New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4206137 Thioalkanoylalkanoic acid compounds June 3, 1980
Thioalkanoylalkanoic acid compounds and salts thereof having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen or lower alkyl;R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR2## A and B each is hydrogen or join together as a polymethylene ch
4206122 Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor June 3, 1980
Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde, and intermediates therefor, which have the general formula ##STR1## wherein R is hydrogen, lower alkanoyl or ##STR2## R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or hydroxy;R.sub.3 is hydroxymethyl
4206121 Substituted acyl derivatives of amino acids June 3, 1980
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4200649 Relieving hypertension with carboxyalkylacylamino acids April 29, 1980
New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
4199512 Compounds for alleviating hypertension April 22, 1980
A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
4198517 Histidine derivatives April 15, 1980
New derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
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