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Inventor:
Olson; Richard E.
Address:
Wilmington, DE
No. of patents:
50
Patents:












Patent Number Title Of Patent Date Issued
7718795 Succinoylamino benzodiazepines as inhibitors of a.beta. protein production May 18, 2010
This invention relates to novel lactams having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7655647 Substituted lactams as inhibitors of A.beta. protein production February 2, 2010
This invention relates to novel lactams of Formula (I): ##STR00001## having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the productio
7528249 Cyclic malonamides as inhibitors of a.beta. protein production May 5, 2009
This invention relates to novel cyclic malonamides having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.bet
7507815 Succinoylamino lactams as inhibitors of a-.beta. protein production March 24, 2009
This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
7498324 Substituted lactams as inhibitors of A.beta. protein production March 3, 2009
This invention relates to novel lactams of Formula (I): ##STR00001## having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the productio
7456278 Lactams substituted by cyclic succinates as inhibitors of A.beta. protein production November 25, 2008
This invention relates to novel lactams having the Formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7456172 Succinoylamino benzodiazepines as inhibitors of A.beta. protein production November 25, 2008
This invention relates to novel lactams having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7423033 Hydroxyalkanoylaminolactams and related structures as inhibitors of a.beta. protein production September 9, 2008
This invention relates to novel lactams having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7390896 Cyclic malonamides as inhibitors of A.beta. protein production June 24, 2008
This invention relates to novel cyclic malonamides having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.bet
7390802 Substituted lactams as inhibitors of A.beta. protein production June 24, 2008
This invention relates to novel lactams of Formula (I): ##STR00001## having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the productio
7354914 Lactams substituted by cyclic succinates as inhibitors of A.beta. protein production April 8, 2008
This invention relates to novel lactams having the Formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7342008 Hydroxyalkanoylaminolactams and related structures as inhibitors of A.beta. protein production March 11, 2008
This invention relates to novel lactams having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7304056 Succinoylamino lactams as inhibitors of A.beta. protein production December 4, 2007
This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
7304055 Succinoylamino lactams as inhibitors of A.beta. protein production December 4, 2007
This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
7304049 Succinoylaminobenzodiazepines as inhibitors of A.beta. protein production December 4, 2007
This invention relates to novel lactams having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7276496 Cyclic malonamides as inhibitors of A.beta. protein protection October 2, 2007
This invention relates to novel cyclic malonamides having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.bet
7276495 Substituted lactams as inhibitors of A.beta. protein production October 2, 2007
This invention relates to novel lactams of Formula (I): ##STR00001## having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the productio
7153491 Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and December 26, 2006
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifyi
7112583 Hydroxyalkanoylaminolactams and related structures as inhibitors of A.beta. protein production September 26, 2006
This invention relates to novel lactams having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7101870 Succinoylamino lactams as inhibitors of A-.beta. protein production September 5, 2006
This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
7053084 Succinoylamino benzodiazepines as inhibitors of A.beta. protein production May 30, 2006
This invention relates to novel lactams having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide,
7053081 Cyclic malonamides as inhibitors of A-.beta. protein production May 30, 2006
This invention relates to novel cyclic malonamides having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.bet
6962913 Benzo-1,4-diazepin-2-ones as inhibitors of A.beta. protein production November 8, 2005
This invention relates to novel compounds of the class of succinoyl lactams, such as diazepinee of Formula (Id), ##STR1##or a pharmaceutically acceptable salt thereof, as described above, having drug and bio-affecting properties. These novel compounds inhibit the processing of amyloi
6960576 Hydroxyalkanoylaminolactams and related structures as inhibitors of A.beta. protein production November 1, 2005
This invention relates to novel lactams having the formula (I): ##STR1##to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
6958329 Lactams substituted by cyclic succinates as inhibitors of A-.beta. protein production October 25, 2005
This invention relates to novel lactams having the Formula (I): ##STR1##to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
6900199 Substituted lactams as inhibitors of A.beta. protein production May 31, 2005
This invention relates to novel lactams of Formula (I): ##STR1##having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of
6878363 Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and April 12, 2005
A method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Radiolabelled small molecule inhibitors identified by the
6794381 Succinoylamino lactams as inhibitors of a.beta. protein September 21, 2004
This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
6759404 Cyclic malonamides as inhibitors of a.beta. protein production July 6, 2004
Novel cyclic malonamides having the formula (I): ##STR1##and their pharmaceutical compositions. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neur
6737038 Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and May 18, 2004
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying
6632812 Substituted lactams as inhibitors of A.beta. protein production October 14, 2003
This invention relates to novel lactams of Formula (I): ##STR1##having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of
6525044 Succinoylamino carbocycles and heterocycles as inhibitors of a-.beta. protein production February 25, 2003
This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.b
6509333 Lactams substituted by cyclic succinates as inhibitors of A.beta. protein production January 21, 2003
This invention relates to novel lactams having the Formula (I): ##STR1##to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby
6348504 Oxime ethers as IIb/IIa antagonists February 19, 2002
##STR1##This invention relates generally to oxime ethers which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these
6331408 Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production December 18, 2001
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying
6218391 Triazinones and derivatives thereof April 17, 2001
Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1##and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
6159980 Pyrazinones and triazinones and their derivatives thereof December 12, 2000
Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
5545651 Imidazole 5-position substituted angiotensin II antagonists August 13, 1996
Novel substituted imidazoles of Formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
5395844 Imidazole 5-position substituted angiotensin II antagonists March 7, 1995
Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: ##STR1## These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)me thyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino)
5389635 4- or 5-heterocyclic substituted imadazoles as angiotensin-II antagonists February 14, 1995
Heterocycle substituted imidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: ##STR1##
5308846 Quinazolinones May 3, 1994
Substituted quinazolinones and pyridopyrimidines of structural formula 1 ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the renin-angiotensin system (RAS) such as hypertension, congestive heart failure, ocular hypertension and certain CNS diso
5256667 Quinazolinones and pyridopyrimidinones October 26, 1993
Substituted quinazolinones and pyridopyrimidines of structural formula I ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the renin-angiotensin system (RAS) such as hypertension, congestive heart failure, ocular hypertension and certain CNS diso
5219856 Angiotensin-II receptor blocking, heterocycle substituted imidazoles June 15, 1993
Novel heterocycle substituted imidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: ##STR1##
5202322 Quinazolinone and pyridopyrimidine a-II antagonists April 13, 1993
Substituted quinazolinones and pyridopyrimidines of structural formula 1 ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the reninangiotensin system (RAS) such as hypertension, congestive heart failure, ocular hypertension and certain CNS disor
5084465 Antifungal carbinols January 28, 1992
Antifungal carbinols, particularly .alpha.-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond or an oxygen atom with the provis
4980367 Antifungal carbinols December 25, 1990
Antifungal carbionols, particularly .alpha.-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond or an oxygen atom with the provi
4965281 Antifungal carbinols October 23, 1990
Antifungal carbinols, particularly .alpha.-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond or an oxygen atom with the provis
4965280 Antifungal carbinols October 23, 1990
Antifungal carbinols, particularly .alpha.-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond or an oxygen atom with the provis
4952232 Antifungal carbinols August 28, 1990
Antifungal carbinols, particularly .alpha.-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or agriculturally suitable salt thereof wherein E is a bond or an oxygen atom with the provis
4729986 Fungicidal triazoles and imidazoles March 8, 1988
Substituted silylmethyl 1,2,4-triazoles and imidazoles also having selected substituents on the heterocyclic ring, agriculturally useful compositions comprising such compounds and the use of such compounds as fungicides.










 
 
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