A synthetic particulate vector comprising a non-liquid hydrophilic nucleus which does not have an external lipid layer grafted thereon. A method for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtainable through said method, and pharmaceutical,
A particulate carrier, including a hydrophilic, non-liquid core, a first layer or ring of lipid nature bonded to the core by covalent bonds and a second layer or outer shell of amphiphilic compounds bonded to the first lipid by hydrophobic interactions.