| Patent Number |
Title Of Patent |
Date Issued |
| 7557111 |
Substituted thieno[3,2-d]pyrimidines as CRF receptor antagonists |
July 7, 2009 |
| An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chore |
| 7381746 |
2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative |
June 3, 2008 |
| One object of the present invention is to provide a drug that is effective in treatments for and prevention of psychiatric disorders and in treatments for and prevention of neurological diseases, inhibiting a Group II metabotropic glutamate receptor.The object is solved by a 2-amino- |
| 7365078 |
Triaza-cyclopenta[cd]indene derivatives |
April 29, 2008 |
| An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chore |
| 7160900 |
Tetrahydropyridino or piperidino heterocyclic derivatives |
January 9, 2007 |
| A tetrahydropyridino or piperidino heterocyclic derivative represented by the formula [I]: A-Het [I] has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved. |
| 7157594 |
6-Fluorobicyclo[3.1.0]hexane derivatives |
January 2, 2007 |
| An antidepressant comprising, as an active ingredient, a compound having an antagonistic effect on group II metabotropic glutamate receptors, as well as a 2-amino-3-alkoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative of Formula [I]: ##STR00001## [wherein R.sup.1 and |
| 6894168 |
Carbamoyl tetrahydropyridine derivatives |
May 17, 2005 |
| Carbamoyl tetrahydropyridine derivatives represented by the formula: ##STR1##[in the formula, R.sup.1 and R.sup.2 are identical or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, or the like; Y.sup.1 --Y.sup.2 represents (R.sup.4)C.dbd.C(R.sup.5), (R.sup.6 |
| 6870069 |
Phenyloxyaniline derivatives |
March 22, 2005 |
| A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1): ##STR1##wherein X.sup.1 and X.sup.2 are same or different and each is hydrogen atom or halogen atom; R.sup.1 a |
| 6852732 |
Tetrahydropyridino or piperidino heterocylic derivatives |
February 8, 2005 |
| A tetrahydropyridino or piperidino heterocyclic derivative represented by the formula [I]:has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved. |
| 6806275 |
Arylpiperidine derivatives and use thereof |
October 19, 2004 |
| The present invention provides an arylpiperidine derivative of the formula (I) or a pharmaceutically acceptable salt thereof, which has antipsychotic effect: ##STR1##wherein D is a carbon atom or a nitrogen atom, E is a CH group or a nitrogen atom, G is an oxygen atom, a sulfur atom, |
| 6600038 |
Carbamoyl tetrahydropyridine derivatives |
July 29, 2003 |
| Carbamoyl tetrahydropyridine derivatives represented by the formula: ##STR1##[in the formula, R.sup.1 and R.sup.2 are identical or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, or the like; Y.sup.1 -Y.sup.2 represents (R.sup.4)C.dbd.C(R.sup.5), (R.sup.6) |
| 6500958 |
Carboxylic acid derivatives and process for producing the same |
December 31, 2002 |
| The present invention relates to compounds which are useful for efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acids.The compounds according to the present invention comprise 2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivatives represented by the formula as |
| 6479674 |
Carboxylic acid derivatives and process for producing same |
November 12, 2002 |
| The present invention relates to compounds which are useful for efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acids.The compounds according to the present invention comprise 2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivatives represented by the formula as |
| 6476056 |
Heterocycle substituted aryloxyaniline derivatives and their use as MDR ligands |
November 5, 2002 |
| An aryloxyaniline derivative represented by the formula: ##STR1##wherein Ar.sup.1 and Ar.sup.2 are the same or different, and are each a substituted or unsubstituted phenyl group, a substituted or unsubstituted pyridyl group or a naphthyl group, provided that Ar.sup.1 and Ar.sup.2 are |
| 6407121 |
Arylpiperidine derivatives and use thereof |
June 18, 2002 |
| The present invention provides an arylpiperidine derivative of the formula (I) or a pharmaceutically acceptable salt thereof, which has antipsychotic effect: ##STR1##wherein D is a carbon atom or a nitrogen atom, E is a CH group or a nitrogen atom, G is an oxygen atom, a sulfur atom, |
| 6392086 |
Intermediates and process for producing fluorine-containing amino acid compound by using the sam |
May 21, 2002 |
| The present inventions relate to a (1S,5R,6S)- or (1SR, 5RS, 6SR)-3-fluoro-2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylic acid derivative represented by Formula (1): ##STR1##[in the formula, R represents OR.sup.1 or NR.sup.1 R.sup.2, wherein R.sup.1 and R.sup.2 are identical or different, |
| 6380384 |
1,2-dihydro-2-oxoquinoline derivatives |
April 30, 2002 |
| A 1,2-dihydro-2-oxoquinoline derivative represented by the formula: ##STR1##wherein Ar is a pyridyl group or a group represented by the formula: ##STR2##(wherein X.sup.3 and X.sup.4 are the same or different, and are each a hydrogen atom, a halogen atom, a C.sub.1-5 alkyl group, a C.sub. |
| 6333428 |
6-fluorobicyclo[3.1.0]hexane derivatives |
December 25, 2001 |
| The present invention provides fluorobicyclo[3.1.0]hexane derivatives represented by the formula ##STR1##[wherein R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.3-8 cycloalkyl group or a C.sub.3-8 cycloalkyl-C.sub. |
| 6333358 |
Aryloxyaniline derivatives |
December 25, 2001 |
| An aryloxyaniline derivative represented by the formula: ##STR1##wherein Ar.sup.1 and Ar.sup.2 are each a substituted or unsubstituted phenyl group, pyridyl group or naphthyl group, R.sup.1 is a hydrogen atom, an alkyl group, etc., X.sup.1 is a hydrogen atom, an alkyl group, etc., y. |
| 6329525 |
1,2-Dihydro-2-oxoquinoline derivatives |
December 11, 2001 |
| A 1,2-dihydro-2-oxoquinoline derivative represented by the formula: ##STR1##wherein Ar is a pyridyl group or a group represented by the formula: ##STR2##(wherein X.sup.3 and X.sup.4 are the same or different, and are each a hydrogen atom, a halogen atom, a C.sub.1-5 alkyl group, a C.sub. |
| 6316498 |
Fluorine-containing amino acid derivatives |
November 13, 2001 |
| Fluorine-containing amino acid derivatives represented general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, wherein X.sup.1 represents hydrogen or fluorine; and R.sup.1 and R.sup.2 are the same or different and each represents hydrogen or lower C.sub.1- |
| 6291467 |
Heteroaromatic derivatives |
September 18, 2001 |
| An aromaheterocyclic derivative represented by the formula: ##STR1##wherein Z is a group represented by the following formula: ##STR2##wherein Ar.sup.1 is a phenyl group or a phenyl group substituted with a halogen atom or an alkyl group of 1 to 5 carbon atoms, R.sup.2 is an alkyl gr |
| 6281355 |
Nitrogen-containing tetracyclic compounds |
August 28, 2001 |
| A nitrogen-containing tetracyclic compound represented by the formula: ##STR1##wherein Y.sup.1 --Y.sup.2 --Y.sup.3 is N--C.dbd.N or a group represented by the formula: C.dbd.C--NR.sup.3 (wherein R.sup.3 is a hydrogen atom, a C.sub.1-5 alkyl group or a nitrogen-containing C.sub.2-10 alkyl |
| 6187781 |
4-Tetrahydropyridylpyrimidine derivatives |
February 13, 2001 |
| A 4-tetrahydropyridylpyrimidine compound represented by formula (I): ##STR1##wherein Ar represents a phenyl group substituted with 1 to 3 substituents selected from a halogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, and a trifluoromethy |
| 6166033 |
2-carbonylthiazole derivatives and use of the same |
December 26, 2000 |
| This invention provides a 2-carbonylthiazole derivative represented by formula (I): ##STR1## wherein each of Ar.sup.1 and Ar.sup.2 represents a phenyl group or a substituted phenyl group; R.sup.1 represents an alkoxy group having 1 to 5 carbon atoms, a hydroxyl group or an amino |
| 5990151 |
Optically active substituted phenylalkylamine derivatives |
November 23, 1999 |
| The present invention relates to an optically active, substituted phenylalkylamine derivative represented by Formula [1]: ##STR1## wherein A is a substituted or non-substituted phenyl or thienyl; X.sup.1 is hydrogen, halogen, hydroxyl or a substituted or non-substituted C.sub.1-5 |
| 5495046 |
Alkoxyphenylalkylamine derivatives |
February 27, 1996 |
| An alkoxyphenylalkylamine derivative represented by the following formula: ##STR1## (wherein X.sup.1 and X.sup.2 may be either the same or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an |
