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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Nakamura; Kazuyasu
Address:
Machida, JP
No. of patents:
38
Patents:












Patent Number Title Of Patent Date Issued
8197814 Method for treating the Th2-mediated disease June 12, 2012
A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereo
8173781 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth fa May 8, 2012
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
8158760 Glycoengineered, recombinant antibody April 17, 2012
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
8143058 Human CDR-grafted antibody and antibody fragment thereof March 27, 2012
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically
8093362 Anti-PERP recombinant antibody January 10, 2012
An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence o
8076458 Anti-claudin-4 antibody December 13, 2011
An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as "CLDN4") gene or a polypeptide encoded by a Claudin-3 (hereinaf
8067232 Antibody composition-producing cell with inactivated A-1,6-fusocyltransferase November 29, 2011
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
8039595 Glycoengineered, recombinant antibody to CCR-4 with reduced fucosylation October 18, 2011
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7939077 Humanized antibody against fibroblast growth factor-8 and antibody fragment thereof May 10, 2011
The present invention relates to an antibody against FGF-8, particularly a humanized antibody against FGF-8 and the antibody fragment thereof, a DNA sequence encoding the above antibody or the antibody fragment, a vector comprising the DNA sequence and a host cell transformed by the
7851601 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth fa December 14, 2010
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
7846725 Antibody composition-producing cell in which enzyme expression is inhibited by RNAi December 7, 2010
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7842797 Human CDR-grafted antibody and antibody fragment thereof November 30, 2010
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically
7763246 Method of modulating the activity of functional immune molecules to platelet-derived growth fact July 27, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7741442 Antibody composition exhibiting increased cellular cytotoxicity due to glycosylation June 22, 2010
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7737325 Antibody composition-producing cell June 15, 2010
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-modulated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7718175 Method of modulating the activity of functional immune molecules to interleukin-5 receptor prote May 18, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7708997 Method of modulating the activity of functional immune molecules May 4, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7708992 Methods for producing antibody compositions with increased ADCC May 4, 2010
The invention relates to methods for modulating the antibody-dependent cellular cytotoxicity of an IgG antibody composition.
7687061 Method of modulating the activity of functional immune molecules to Her-2 March 30, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7682611 Method of modulating the activity of functional immune molecules to CXCR4 protein March 23, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7682610 Method of modulating the activity of functional immune molecules March 23, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7666418 Method for treating Th2-mediated disease February 23, 2010
A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a
7655228 Method of modulating the activity of functional immune molecules to GM2 February 2, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7651688 Method of modulating the activity of functional immune molecules to CD52 January 26, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7615215 Anti-human VEGF receptor Flt-1 monoclonal antibody November 10, 2009
The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1
7615214 Anti-human VEGF receptor Flt-1 monoclonal antibody November 10, 2009
The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1
7504104 Human CDR-grafted antibody and antibody fragment thereof March 17, 2009
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically
7438911 Antibody against human insulin-like growth factor October 21, 2008
For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides a
7425446 Antibody composition-producing cell September 16, 2008
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7393683 Mammalian host cell modified by RNAi to inhibit .alpha. 1,6-fucosyltransferase July 1, 2008
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7253263 Complementarity determining region-grafted antibody against ganglioside GD3 and derivative of an August 7, 2007
The present invention relates to a human CDR-grafted antibody against ganlioside GD3 (hereinafter referred to "GD3"), derivatives of an anti-GD3 antibody and cytokine, and use for treatment and diagnosis of the antibody and the derivatives.
7241568 Anti-fibroblast growth factor-8 monoclonal antibody July 10, 2007
A method for preventing or treating a disease, comprising administering to human or animal in need of such prevention or treatment an effective amount of a monoclonal antibody which specifically binds to FGF-8 and inhibits FGF-8 activity.
7238354 Method of treating atopic dermatitis using antibody against human interleukin-5 receptor alpha c July 3, 2007
The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor .alpha. chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized ant
7214775 Method of modulating the activity of functional immune molecules May 8, 2007
The invention relates to a method for controlling the activity of an immunologically functional molecules, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule h
7052693 Anti-human VEGF receptor FLT-1 monoclonal antibody May 30, 2006
The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1
6989145 Recombinant antibody and antibody fragment January 24, 2006
A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a
6986890 Anti-human VEGF receptor Flt-1 monoclonal antibody January 17, 2006
The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1
6946292 Cells producing antibody compositions with increased antibody dependent cytotoxic activity September 20, 2005
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the










 
 
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