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Inventor: Musser; John H.
Address: Alameda, CA
No. of patents: 15
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 5420289 |
Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as |
May 30, 1995 |
| This invention relates to substituted indole derivatives possessing lipoxygenase inhibitory, phospholipase A.sub.2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and cytoprotective agents. |
| 5364944 |
Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid compounds |
November 15, 1994 |
| There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA.sub.2 and lipoxygenase, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, |
| 5286730 |
Method of treating immunoinflammatory disease |
February 15, 1994 |
| This invention provides a method of treating immunionflammatory skin disease in a mammal in need thereof which comprises administering an antiimmunoinflammatory amount of rapamycin, alone or in combination with cyclosporin A, orally, parenterally, intranasally, intrabronchially, topi |
| 5250693 |
Quinolinylmethoxy naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
October 5, 1993 |
| There are disclosed compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl;Y is ##STR2## or a pharmaceutically acceptable salt thereof, and its use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic |
| 5239078 |
Matrix metalloprotease inhibitors |
August 24, 1993 |
| Compounds of the formulas ##STR1## wherein each R.sup.1 is independently H or alkyl (1-8C) and R.sup.2 is alkyl (1-8C) or wherein the proximal R.sup.1 and R.sup.2 taken together are --(CH.sub.2).sub.p -- wherein p=3-5;R.sup.3 is H or alkyl (1-4C);R.sup.4 is fused or conjugated unsubs |
| 5229516 |
Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as |
July 20, 1993 |
| There are disclosed compounds of the formulawhereinA is C.sub.4 -C.sub.8 alkyl, phenoxyethyl, phenoxyphenyl or a group having the formula ##STR1## wherein ##STR2## R.sup.1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl;R.sup.2 is hydrogen or lowe |
| 5218124 |
Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives as inhibitors of |
June 8, 1993 |
| There are disclosed compounds of the formulawhereinA is a group having the formula ##STR1## wherein X is --N-- or ##STR2## Z is ##STR3## R.sup.1 is hydrogen, lower alkyl or phenyl; R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a benzene ri |
| 5216165 |
N-substituted aminoquinolines as analgesic agents |
June 1, 1993 |
| There are disclosed compounds of the formula ##STR1## wherein R is hydrogen, halo or trifluoromethyl;R.sup.1 is hydrogen or X;R.sup.2 is hydrogen or X; with the proviso that when R.sup.1 is X, R.sup.2 is hydrogen, and when R.sup.1 is hydrogen, R.sup.2 is X;X is the moiety ##STR2## |
| 5208344 |
Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
May 4, 1993 |
| There are disclosed compounds of the formula ##STR1## wherein A is alkyl of 3-19 carbon atoms, diloweralkyl allyl, dihaloallyl, diphenylallyl, lower alkynyl, ##STR2## with the proviso that A is not quinolinyl; W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O--;X i |
| 5202332 |
Rapamycin analog as immunosuppressant |
April 13, 1993 |
| Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities. |
| 5169851 |
Rapamycin analog as immunosuppressants and antifungals |
December 8, 1992 |
| Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosupressant, antifungal, and antiinflammatory activities. |
| 5138051 |
Rapamycin analogs as immunosuppressants and antifungals |
August 11, 1992 |
| Reduction of C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities. |
| 5120727 |
Rapamycin dimers |
June 9, 1992 |
| A rapamycin dimer of general formula (1) ##STR1## wherein A is --(CH.sub.2).sub.n --, --(CH.sub.2)n--(CH.dbd.CH)--(CH.sub.2).sub.m --, --(CH.sub.2)n--(--C.tbd.C--)--(CH.sub.2).sub.m --, ##STR2## substituted alkyl, substituted alkenyl, substituted alkynyl, and substituted |
| 5120725 |
Bicyclic rapamycins |
June 9, 1992 |
| A bicyclic derivative of rapamycin of general formula (1) ##STR1## wherein ##STR2## n=2 to 10, m=2 to 10 andn=m or n.noteq.mor a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host |
| 5118678 |
Carbamates of rapamycin |
June 2, 1992 |
| A compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or --CONH(CR.sup.3 R.sup.4).sub.n --X;R.sup.3 and R.sup.4 are each, independently, hydrogen, alkyl, aralkyl, cycloalkyl, halogen, or trifluoromethyl;X ix hydrogen, lower alkyl, cycloalk |
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