| Patent Number |
Title Of Patent |
Date Issued |
| 7553852 |
Caspase inhibitors and uses thereof |
June 30, 2009 |
| The present invention relates to compounds of formula I: ##STR00001## useful as inhibitors of caspases. The present invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for preparing the compounds, and methods of using the compounds an |
| 7528142 |
Aminopyrimidines useful as kinase inhibitors |
May 5, 2009 |
| The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and |
| 7507826 |
Azaindoles useful as inhibitors of JAK and other protein kinases |
March 24, 2009 |
| The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. |
| 7442790 |
Caspase inhibitors and uses thereof |
October 28, 2008 |
| This invention provides caspase inhibitors of formula I: ##STR00001## wherein Z is oxygen or sulfur; R.sup.1 is hydrogen, --CHN.sub.2, R, CH.sub.2OR, CH.sub.2SR, or --CH.sub.2Y; between R.sup.3 and R.sup.4 represents a single or double bond; Y is an electronegative leaving group; R. |
| 7410956 |
Caspase inhibitor prodrugs |
August 12, 2008 |
| The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. This invention further |
| 7351702 |
Caspase inhibitors and uses thereof |
April 1, 2008 |
| This invention provides compounds of formula I: ##STR00001## wherein Z is oxygen or sulfur; R.sup.1 is hydrogen, --CHN.sub.2, R, CH.sub.2OR, CH.sub.2SR, or --CH.sub.2Y; next to R.sup.3 represents a single or double bond; Y is an electronegative leaving group; R.sup.2 is CO.sub.2H, |
| 7335792 |
Process for synthesizing aspartic and glutamic acid derivatives especially useful as intermediat |
February 26, 2008 |
| The invention relates to novel diazoketone derivatives. The invention also relates to processes for homologation of these diazoketone derivatives. The processes are useful for preparing compounds that are caspase inhibitors. |
| 7053057 |
Caspase inhibitors and uses thereof |
May 30, 2006 |
| This invention provides caspase inhibitors having the formula: ##STR00001## wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R.sup.1 is hydrogen, CHN.sub.2, R, or --CH.sub.2Y; R is an optionally substituted group selected fr |
| 7041687 |
Indazole compounds useful as protein kinase inhibitors |
May 9, 2006 |
| The present invention provides compounds of formula I: ##STR00001## or a pharmaceutically acceptable derivative thereof, wherein R.sup.1, R.sup.2, V.sup.1, V.sup.2, and V.sup.3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibito |
| 6800619 |
Caspase inhibitors and uses thereof |
October 5, 2004 |
| Described herein are compounds that are useful as caspase inhibitors having the formula: ##STR1##wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R.sup.1 is hydrogen, CN, CHN.sub.2, R, or CH.sub.2 Y; R is an optionally substi |
