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Inventor:
Middleton; Steven A.
Address:
Flemington, NJ
No. of patents:
19
Patents:












Patent Number Title Of Patent Date Issued
8299082 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives October 30, 2012
1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(hete
8153791 Substituted pyrimidinyl oxime kinase inhibitors April 10, 2012
The present invention is directed to substituted pyrimidine compounds of formula (I): ##STR00001## and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
7888380 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives February 15, 2011
1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(hete
7855205 Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders December 21, 2010
The present invention provides pyrimidinyl substituted fused-pyrrolyl compounds of Formula (I) ##STR00001## and pharmaceutical compositions comprising the compounds and methods of synthesis and use thereof. The compounds are kinase inhibitors useful in treating or ameliorating a kin
7659284 Thiazolopyridine kinase inhibitors February 9, 2010
The present invention is directed to novel thiazolopyridines, pharmaceutical compositions thereof, and the use thereof as inhibitors of ATP-protein kinase interactions. The thiazolopyridine compounds have the following Formula (I): ##STR00001##
7655670 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators February 2, 2010
The present invention is directed to novel 3-spirocyclic indolyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the ORL-1 receptor.
7605154 Substituted Thiazolo [4,5-d]pyrimidines as protein kinase inhibitors October 20, 2009
The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof ##STR00001## and the use thereof as inhibitors of ATP-protein kinase interactions.
7582649 Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment September 1, 2009
The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula ##STR00001## wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein cou
7541367 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders June 2, 2009
The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): ##STR00001## and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interacti
7517885 Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds April 14, 2009
The present invention relates to substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds of Formula (I) ##STR00001## and pharmaceutically acceptable forms thereof, as .alpha..sub.1a/.alpha..sub.1d adrenoreceptor modulators for the treatment of benign prostatic hypertroph
7482348 Piperazinyl substituted cyclohexane-1,4-diamines January 27, 2009
The present invention relates to piperazine substituted cyclohexane-1,4-diamine compounds of Formula (I) ##STR00001## and pharmaceutically acceptable forms thereof, as .alpha..sub.1a/.alpha..sub.1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower
7470711 Piperidinyl substituted cyclohexane-1,4-diamines December 30, 2008
The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) ##STR00001## and pharmaceutically acceptable forms thereof, as .alpha..sub.1a/.alpha..sub.1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower
7459557 Substituted isoindole-1,3-diones December 2, 2008
The present invention relates to substituted isoindole-1,3-dione compounds of Formula (I) ##STR00001## and pharmaceutically acceptable forms thereof, as .alpha..sub.1a/.alpha..sub.1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract
7427625 Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors September 23, 2008
The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): ##STR00001## and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or conditi
7317031 Substituted triazole diamine derivatives as kinase inhibitors January 8, 2008
The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
7109220 Amino substituted pyridinyl methanone compounds useful in treating kinase disorders September 19, 2006
The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated di
7081463 Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment July 25, 2006
The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula ##STR00001## wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein c
6924302 Substituted triazole diamine derivatives as kinase inhibitors August 2, 2005
The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
6221608 Methods for identifying erythropoietin receptor binding protein April 24, 2001
The extracellular domain of the human erythropoietin receptor (EPO binding protein, EBP) has been expressed and overproduced in E. coli. Control of oxygen levels and pH during high density fermentation allows the production of only the protein variant with the native amino terminus.










 
 
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