| Patent Number |
Title Of Patent |
Date Issued |
| 7011619 |
Apparatus and methods for radiotherapy |
March 14, 2006 |
| The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of |
| 5716642 |
Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derive |
February 10, 1998 |
| This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of suitable surface-modif |
| 5662883 |
Microprecipitation of micro-nanoparticulate pharmaceutical agents |
September 2, 1997 |
| It has been known that administration of pharmaceutical agents (both diagnostic and therapeutic) with poor water solubility in the form of particles less than 400 nm in diameter produces agent formulation with increased bioavailibility. Bioavailability being proportional to the surfa |
| 5569448 |
Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositio |
October 29, 1996 |
| This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a block copolymer linked to at least one anionic group as a surface modifier adsorbed on the surface thereof and a method of making such nanoparticles. The compositions |
| 5560932 |
Microprecipitation of nanoparticulate pharmaceutical agents |
October 1, 1996 |
| This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of a suitable surface |
| 5531979 |
Compositions of iodophenoxy alkanes and iodophenyl ethers and pharmaceutically acceptable clays |
July 2, 1996 |
| Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; |
| 5492687 |
Compositions of iodophenoxy alkylene ethers and pharmaceutically acceptable clays for visualizat |
February 20, 1996 |
| Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkylene ethers and pharmaceutically acceptable clays in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the g |
| 5484585 |
Compositions of iodobenzoic acid derivatives and pharmaceutically acceptable clays for visualiza |
January 16, 1996 |
| Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodobenzoic acid derivatives as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and method |
| 5476646 |
X-ray contrast compositions containing iodophenoxyalkanes and pharmaceutically acceptable clays |
December 19, 1995 |
| Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnos |
| 5472682 |
Compositions of iodophenyl esters and iodophenyl sulfonates and pharmaceutically acceptable clay |
December 5, 1995 |
| Disclosed are x-ray contrast compositions of the formula ##STR1## wherein X is ##STR2## or --SO.sub.2 --; Z is H, halo, methyl, ethyl, n-propyl, C.sub.4 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or |
| 5451393 |
X-ray contrast compositions useful in medical imaging |
September 19, 1995 |
| An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, an |
| 5424056 |
X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable c |
June 13, 1995 |
| Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodoaniline derivative as the x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods fo |
| 5401492 |
Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agen |
March 28, 1995 |
| This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred emb |
| 5360604 |
X-ray contrast compositions containing an organic crystalline X-ray contrast agent in combinatio |
November 1, 1994 |
| Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a crystalline organic constrast agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in di |
| 5352459 |
Use of purified surface modifiers to prevent particle aggregation during sterilization |
October 4, 1994 |
| This invention discloses a composition comprised of nanoparticles having a purified polymeric surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the |
| 5346688 |
Iodinated wetting agents |
September 13, 1994 |
| Compounds having the structure ##STR1## wherein (Z)--COO is the residue of an iodinated aromatic acid; M is H, a cation, --CH.sub.2 CH.sub.2 O--.sub.m H, and --CH.sub.2 CH(OH)O--.sub.p H;m is an integer from 1 to 150;p is an integer from 1 to 50; andL is one or more divalent linking grou |
| 5318767 |
X-ray contrast compositions useful in medical imaging |
June 7, 1994 |
| An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, an |
