Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
McGall; Glenn
Address:
Mountain View, CA
No. of patents:
40
Patents:












Patent Number Title Of Patent Date Issued
7491818 Nucleic acid labeling compounds February 17, 2009
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for en
7468243 2-aminopyrimidin-4-one nucleic acid labeling compounds December 23, 2008
Nucleic acid labeling compounds are disclosed having the formula: ##STR00001## These compounds are useful for attaching a detectable label to a nucleic acid.
7179905 Nucleic acid labeling compounds February 20, 2007
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for en
7144700 Photolithographic solid-phase polymer synthesis December 5, 2006
Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting groups that mask reactive sites on synthesis intermediaries. Preferred groups of photolabile
7129308 Functionalized silicon compounds and methods for their synthesis and use October 31, 2006
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
7129307 Functionalized silicon compounds and methods for their synthesis and use October 31, 2006
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
7125947 Functionalized silicon compounds and methods for their synthesis and use October 24, 2006
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
7098286 Functionalized silicon compounds and methods for their synthesis and use August 29, 2006
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
7060443 Methods for testing oligonucleotide arrays June 13, 2006
Methods for testing oligonucleotide arrays are disclosed including methods for testing the efficiency of nucleotide coupling; methods for testing amounts of deprotected oligonucleotides; methods for determining amounts of depurinated oligonucleotides; and methods of detecting the presenc
7005259 Methods for array preparation using substrate rotation February 28, 2006
Methods are provided for the preparation of polymer arrays on wafers wherein the wafers are rotated between synthesis steps to provide more uniform results across the entire wafer.
6994964 Macromolecular arrays on polymeric brushes and methods for preparing the same February 7, 2006
Polymeric brush substrates and methods for their preparation are provided. Methods are also provided for preparing macromolecular arrays on such polymeric brush substrates. Using polymeric brush substrates allows control over functional site density as well as wettability and porosity
6965020 Nucleic acid labeling compounds November 15, 2005
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for en
6887665 Methods of array synthesis May 3, 2005
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react w
6864059 Biotin containing C-glycoside nucleic acid labeling compounds March 8, 2005
Nucleic acid labeling compounds including the following structure are disclosed: ##STR1##wherein A is a triphosphate group with apporpriate counterions, said counterions selected from the group consisting of H+, Na+, Li+, K+, and NH.sub.4 +; X is O; Y is OH; Z is OH; L is selected fr
6844433 Nucleic acid labeling compounds January 18, 2005
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for en
6833450 Phosphite ester oxidation in nucleic acid array preparation December 21, 2004
Methods are provided for preparing nucleic acid arrays on a support. In these methods a plurality of nucleic acids are synthesized on the support and the synthesis steps include oxidizing a phosphite triester nucleic acid linkage to a phosphate triester nucleic acid linkage using a solut
6824866 Porous silica substrates for polymer synthesis and assays November 30, 2004
Methods are provided for making and using thin films of porous silica substrates to synthesize arrays of polymers. Methods are also provided for assaying such polymers on porous silica substrates. The porous silica substrates offer an increase in array density and signal enhancement over
6806361 Methods of enhancing functional performance of nucleic acid arrays October 19, 2004
Methods are provided for preparing nucleic acid arrays on a support. In these methods a plurality of nucleic acids are synthesized on the support and the synthesis steps are followed by drying steps in which the array is exposed to a dry atmosphere following the synthesis steps.
6800439 Methods for improved array preparation October 5, 2004
Improved nucleic acid arrays are provided which have been prepared in a non-oxidizing atmosphere.
6773888 Photoactivatable silane compounds and methods for their synthesis and use August 10, 2004
In one aspect of the invention, photoactivatable silane compounds and methods for their synthesis and use are provided. In one embodiment, the photoactivatable silane compounds synthesized are represented by a formula: PG-LS-SN, wherein PG is a photoactivatable group, LS is a linkage
6743882 Functionalized silicon compounds and methods for their synthesis and use June 1, 2004
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
6706875 Substrate preparation process March 16, 2004
The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences The methods of the invention combine high through
6667394 Printing oligonucleotide arrays December 23, 2003
A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier materi
6632605 Hybridization assays on oligonucleotide arrays October 14, 2003
This invention provides methods of performing nucleic acid hybridization assays on high-density substrate-bound oligonucleotide arrays involving including in the hybridization mixture an isostabilizing agent, a denaturing agent or a renaturation accelerant.
6596856 Nucleic acid labeling compounds July 22, 2003
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for en
6576425 Methods for testing oligonucleotide arrays June 10, 2003
Methods for testing oligonucleotide arrays are disclosed including methods for testing the efficiency of nucleotide coupling; methods for testing amounts of deprotected oligonucleotides; methods for determining amounts of depurinated oligonucleotides; and methods of detecting the presenc
6486287 Functionalized silicon compounds and methods for their synthesis and use November 26, 2002
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
6486286 Use of hexahydrolupulones as antibacterial agents November 26, 2002
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
6429275 Functionalized silicon compounds and methods for their synthesis and use August 6, 2002
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
6410675 Functionalized silicon compounds and methods for their synthesis and use June 25, 2002
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
6307042 Substrate preparation process October 23, 2001
The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throug
6262216 Functionalized silicon compounds and methods for their synthesis and use July 17, 2001
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino,
6239273 Printing molecular library arrays May 29, 2001
A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier materi
6238862 Methods for testing oligonucleotide arrays May 29, 2001
Methods for testing oligonucleotide arrays are disclosed including methods for testing the efficiency of nucleotide coupling; methods for testing amounts of deprotected oligonucleotides; methods for determining amounts of depurinated oligonucleotides; and methods of detecting the presenc
6045996 Hybridization assays on oligonucleotide arrays April 4, 2000
This invention provides methods of performing nucleic acid hybridization assays on high-density substrate-bound oligonucleotide arrays involving including in the hybridization mixture an isostabilizing agent, a denaturing agent or a renaturation accelerant.
5959098 Substrate preparation process September 28, 1999
The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throug
5843655 Methods for testing oligonucleotide arrays December 1, 1998
Methods for testing oligonucleotide arrays are disclosed including methods for testing the efficiency of nucleotide coupling; methods for testing amounts of deprotected oligonucleotides; methods for determining amounts of depurinated oligonucleotides; and methods of detecting the presenc
5831070 Printing oligonucleotide arrays using deprotection agents solely in the vapor phase November 3, 1998
A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier materi
5658734 Process for synthesizing chemical compounds August 19, 1997
The present invention relates to a process for synthesizing on a single substrate a plurality of chemical compounds having diverse structures. The process involves the use of a bilayer photoresist to build up selected regions of the array in a step wise fashion.
5599695 Printing molecular library arrays using deprotection agents solely in the vapor phase February 4, 1997
A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier materi










 
 
  Recently Added Patents
Para-xylylene based microfilm elution devices
Optimized control of an energy supplying system and an energy consuming system
Polypropylene bottles
Pulsed plasma with low wafer temperature for ultra thin layer etches
Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency
Method and system for fail-safe call survival
Vaccination with killed but metabolically active (KBMA) protozoans with toll-like receptor agonists
  Randomly Featured Patents
Compound archery bow
Rose plant Jachse
.sup.15O-labeled monosaccharide and producing method thereof
Trough shear diffusor apparatus for fluxing molten metal and method
Carbon nanotube resonators comprising a non-woven fabric of unaligned nanotubes
Au-Ge-Ni ohmic contact for Ga-Al-As compound semiconductor
Methods for evaluating stroke or cardiac ischemia by nucleic acid detection
System for controlling the exposure in a camera
Cathodic protection
Holographic human-machine interfaces