| Patent Number |
Title Of Patent |
Date Issued |
| 8008299 |
Urotensin II receptor antagonists |
August 30, 2011 |
| This invention is directed to a compound of Formula (I): ##STR00001## and forms thereof, wherein A, B, E, G, X and L.sub.2 are as defined herein and their use as urotensin II receptor antagonists. |
| 7855203 |
Indazolyl-substituted pyrroline compounds as kinase inhibitors |
December 21, 2010 |
| The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR00001## useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. |
| 7786135 |
Substituted pyrroline kinase inhibitors |
August 31, 2010 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. |
| 7781450 |
Substituted pyrroline kinase inhibitors |
August 24, 2010 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. |
| 7759380 |
Substituted pyrrolines as kinase inhibitors |
July 20, 2010 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. |
| 7705015 |
Substituted pyrroline kinase inhibitors |
April 27, 2010 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. |
| 7608634 |
Substituted pyrrolines as kinase inhibitors |
October 27, 2009 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. |
| 7524858 |
Substituted pyrroline kinase inhibitors |
April 28, 2009 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. |
| 7329657 |
Indazolyl-substituted pyrroline compounds as kinase inhibitors |
February 12, 2008 |
| The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR00001## useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. |
| 7312306 |
Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators |
December 25, 2007 |
| The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention |
| 7304060 |
Indazolyl-substituted pyrroline compounds as kinase inhibitors |
December 4, 2007 |
| The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR00001## useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. |
| 7232906 |
Substituted pyrrolines as kinase inhibitors |
June 19, 2007 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. |
| 7125878 |
Substituted pyrroline kinase inhibitors |
October 24, 2006 |
| The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. |
| 6943149 |
Benzimidazolone peptidomimetics as thrombin receptor antagonists |
September 13, 2005 |
| The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, |
| 6849643 |
Indazolyl-substituted pyrroline compounds as kinase inhibitors |
February 1, 2005 |
| The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR1##useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. |
| 6747127 |
Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators |
June 8, 2004 |
| The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and |
| 6740657 |
Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists |
May 25, 2004 |
| The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders. |
| 6630451 |
Benzimidazolone peptidometics as thrombin receptor antagonist |
October 7, 2003 |
| The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, |
| 6365617 |
Indole and indazole urea-peptoids as thrombin receptor antagonists |
April 2, 2002 |
| The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis |
| 6218384 |
3-Oxo-pyrido(1,2-a)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)benzimidazole-5-carboxyl der |
April 17, 2001 |
| A compound of the general formula I; ##STR1##is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed. |
| 5639760 |
3-oxo-pyrido(1,2-a)-benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)-benzimidazole-5-carboxyl d |
June 17, 1997 |
| The present invention is directed to compounds of the following formula I: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, A, n, X, and Y are as defined hereinafter. The compounds of formula I are useful in treating central nervous system disorders. The compounds are ligands |
| 5521200 |
2-oxo-pyrrolo[1,2-A]benzimidazole-3-carboxyl derivatives useful in treating central nervous syst |
May 28, 1996 |
| A compound of the general formula I; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed. |
| 5498629 |
Anticonvulsant pseudofructopyranose sulfamates |
March 12, 1996 |
| A compound of the general formula I: ##STR1## is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed. |
| 4908450 |
Certain hexahydro-6-arylpyrrolo[2,1-A]isoquinolines |
March 13, 1990 |
| A diastereoselective process for known antidepressive compounds (I) via reduction of the corresponding alcohol (VII): ##STR1## whereby the product mixture of diastereomers is surprisingly and unexpectedly rich in the content of the trans configuration (II) over the cis configurat |
| 4837328 |
Stereoselective reaction for hexahydro-6-arylpyrrolo(2,1-A) isoquinolines |
June 6, 1989 |
| A diastereoselective process for known antidepressive compounds (I) via reduction of the corresponding alcohol (VII): ##STR1## whereby the product mixture of diastereomers is surprisingly and unexpectedly rich in the content of the trans configuration (II) over the cis configurat |
| 4421917 |
Derivatives of 2-ureido-7-phenylhexahydrobenzo[a]quinolizines |
December 20, 1983 |
| 2-Ureido-7-phenylhexahydrobenzo[a]quinolizines of the structural formula, ##STR1## wherein R.sub.1 =H or lower alkyl (one to three carbons) and R.sub.2 =H, lower alkyl (one to six carbons), or phenyl, and which exhibit antihypertensive activity. |
