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Inventor:
McComsey; David F.
Address:
Warminster, PA
No. of patents:
26
Patents:












Patent Number Title Of Patent Date Issued
8008299 Urotensin II receptor antagonists August 30, 2011
This invention is directed to a compound of Formula (I): ##STR00001## and forms thereof, wherein A, B, E, G, X and L.sub.2 are as defined herein and their use as urotensin II receptor antagonists.
7855203 Indazolyl-substituted pyrroline compounds as kinase inhibitors December 21, 2010
The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR00001## useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
7786135 Substituted pyrroline kinase inhibitors August 31, 2010
The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
7781450 Substituted pyrroline kinase inhibitors August 24, 2010
The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
7759380 Substituted pyrrolines as kinase inhibitors July 20, 2010
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
7705015 Substituted pyrroline kinase inhibitors April 27, 2010
The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
7608634 Substituted pyrrolines as kinase inhibitors October 27, 2009
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
7524858 Substituted pyrroline kinase inhibitors April 28, 2009
The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
7329657 Indazolyl-substituted pyrroline compounds as kinase inhibitors February 12, 2008
The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR00001## useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
7312306 Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators December 25, 2007
The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention
7304060 Indazolyl-substituted pyrroline compounds as kinase inhibitors December 4, 2007
The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR00001## useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
7232906 Substituted pyrrolines as kinase inhibitors June 19, 2007
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
7125878 Substituted pyrroline kinase inhibitors October 24, 2006
The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
6943149 Benzimidazolone peptidomimetics as thrombin receptor antagonists September 13, 2005
The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis,
6849643 Indazolyl-substituted pyrroline compounds as kinase inhibitors February 1, 2005
The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): ##STR1##useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
6747127 Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators June 8, 2004
The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and
6740657 Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists May 25, 2004
The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.
6630451 Benzimidazolone peptidometics as thrombin receptor antagonist October 7, 2003
The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis,
6365617 Indole and indazole urea-peptoids as thrombin receptor antagonists April 2, 2002
The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis
6218384 3-Oxo-pyrido(1,2-a)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)benzimidazole-5-carboxyl der April 17, 2001
A compound of the general formula I; ##STR1##is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
5639760 3-oxo-pyrido(1,2-a)-benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)-benzimidazole-5-carboxyl d June 17, 1997
The present invention is directed to compounds of the following formula I: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, A, n, X, and Y are as defined hereinafter. The compounds of formula I are useful in treating central nervous system disorders. The compounds are ligands
5521200 2-oxo-pyrrolo[1,2-A]benzimidazole-3-carboxyl derivatives useful in treating central nervous syst May 28, 1996
A compound of the general formula I; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
5498629 Anticonvulsant pseudofructopyranose sulfamates March 12, 1996
A compound of the general formula I: ##STR1## is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.
4908450 Certain hexahydro-6-arylpyrrolo[2,1-A]isoquinolines March 13, 1990
A diastereoselective process for known antidepressive compounds (I) via reduction of the corresponding alcohol (VII): ##STR1## whereby the product mixture of diastereomers is surprisingly and unexpectedly rich in the content of the trans configuration (II) over the cis configurat
4837328 Stereoselective reaction for hexahydro-6-arylpyrrolo(2,1-A) isoquinolines June 6, 1989
A diastereoselective process for known antidepressive compounds (I) via reduction of the corresponding alcohol (VII): ##STR1## whereby the product mixture of diastereomers is surprisingly and unexpectedly rich in the content of the trans configuration (II) over the cis configurat
4421917 Derivatives of 2-ureido-7-phenylhexahydrobenzo[a]quinolizines December 20, 1983
2-Ureido-7-phenylhexahydrobenzo[a]quinolizines of the structural formula, ##STR1## wherein R.sub.1 =H or lower alkyl (one to three carbons) and R.sub.2 =H, lower alkyl (one to six carbons), or phenyl, and which exhibit antihypertensive activity.










 
 
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