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Inventor:
McBride; William J.
Address:
Boonton, NJ
No. of patents:
40
Patents:












Patent Number Title Of Patent Date Issued
8277817 PEGylation by the dock and lock (DNL) technique October 2, 2012
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a target agent to a DDD sequence and attaching a PEG
8246960 Methods and compositions for generating bioactive assemblies of increased complexity and uses August 21, 2012
The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) metho
8202509 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules June 19, 2012
The present application discloses compositions and methods of synthesis and use of .sup.68Ga, .sup.18F or .sup.19F labeled molecules of use in PET or MRI imaging. Preferably, the .sup.18F or .sup.19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal
8188239 Multivalent carriers of bi-specific antibodies May 29, 2012
Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targeta
8163291 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers o April 24, 2012
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking
8158573 Therapeutic and diagnostic conjugates for use with multispecific antibodies April 17, 2012
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may
8158129 Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vi April 17, 2012
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequence and attaching a
8153101 Methods and compositions for F-18 labeling of proteins, peptides and other molecules April 10, 2012
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules including but not
8153100 Methods and compositions for F-18 labeling of proteins, peptides and other molecules April 10, 2012
The present application discloses compositions and methods of synthesis and use of .sup.18F or .sup.19F labeled molecules of use in PET or MRI imaging. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled. Preferably, the .sup.18F or .su
8147800 Methods and compositions for F-18 labeling of proteins, peptides and other molecules April 3, 2012
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the described methods. Pref
8147799 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules April 3, 2012
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules including but not
8097252 Methods and compositions for administering therapeutic and diagnostic agents January 17, 2012
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
8038983 Fluorinated carbohydrate conjugates October 18, 2011
Disclosed are novel conjugates that include fluorinated carbohydrate molecules and methods for synthesizing the conjugates. The fluorinated carbohydrate molecule may include a radioisotope. The method of synthesizing the conjugate is useful for labeling selected molecules, and the co
8003111 Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vi August 23, 2011
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequence and attaching a
7993626 Methods and compositions for F-18 labeling of proteins, peptides and other molecules August 9, 2011
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the described methods. Pref
7981398 PEGylation by the dock and lock (DNL) technique July 19, 2011
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a target agent to a DDD sequence and attaching a PEG
7951921 Multivalent carriers of bi-specific antibodies May 31, 2011
Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targeta
7943343 Production and use of novel peptide-based agents for use with bi-specific antibodies May 17, 2011
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten to which antibodie
7914787 Production and use of novel peptide-based agents with bispecific antibodies March 29, 2011
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which compris
7906121 Methods and compositions for generating bioactive assemblies of increased complexity and uses March 15, 2011
The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) metho
7892547 Methods and compositions for administering therapeutic and diagnostic agents February 22, 2011
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
7871622 Stably tethered structures of defined compositions with multiple functions or binding specificit January 18, 2011
The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a
7842279 F-18 peptides for pre targeted positron emission tomography imaging November 30, 2010
F-18 radiolabeled peptides are prepared by reacting a peptide comprising a hydroxylamine, a thiosemicarbazide, a hydrazine or a free amine group with 4-[.sup.18F]Fluorobenzaldehyde. Specific, non-limiting examples of F-18 radiolabeled peptides are described herein. The labeled peptides a
7776311 D-amino acid peptides August 17, 2010
The present invention provides compounds of the formula X--R.sup.1-D-[Dpr, Orn or Lys](A)-R.sup.2(Z)-D-[Dpr, Orn or Lys](B)--R.sup.3(Y)--NR.sup.4R.sup.5; or R.sup.1(X)-D-[Dpr, Orn or Lys](A)-R.sup.2(Z)-D-[Dpr, Orn or Lys](B)--R.sup.3(Y)--NR.sup.4R.sup.5, in which X is a hard acid cat
7666415 Production and use of novel peptide-based agents for use with bi-specific antibodies February 23, 2010
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten to which antibodie
7666400 PEGylation by the dock and lock (DNL) technique February 23, 2010
The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequence and attaching a
7597876 Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules October 6, 2009
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules including but not
7563439 Production and use of novel peptide-based agents for use with bi-specific antibodies July 21, 2009
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been pr
7563433 Methods and compositions for F-18 labeling of proteins, peptides and other molecules July 21, 2009
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules including but not
7560110 Production and use of novel peptide-based agents with bispecific antibodies July 14, 2009
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which compris
7550143 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers o June 23, 2009
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking
7534866 Methods and compositions for generating bioactive assemblies of increased complexity and uses May 19, 2009
The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) metho
7534431 Methods and compositions for administering therapeutic and diagnostic agents May 19, 2009
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
7521416 D-amino acid peptides April 21, 2009
The present invention provides compounds of the formula X--R.sup.1-D-[Dpr, Orn or Lys](A)-R.sup.2(Z)-D-[Dpr, Orn or Lys](B)--R.sup.3(Y)--NR.sup.4R.sup.5; or R.sup.1(X)-D-[Dpr, Orn or Lys](A)-R.sup.2(Z)-D-[Dpr, Orn or Lys](B)--R.sup.3(Y)--NR.sup.4R.sup.5, in which X is a hard acid cat
7521056 Stably tethered structures of defined compositions with multiple functions or binding specificit April 21, 2009
The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a
7429381 Production and use of novel peptide-based agents for use with bi-specific antibodies September 30, 2008
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been pr
7405320 Therapeutic and diagnostic conjugates for use with multispecific antibodies July 29, 2008
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may
7172751 D-amino acid peptides February 6, 2007
The present invention provides compounds of the formula X--R.sup.1-D-[Dpr, Orn or Lys](A)-R.sup.2(Z)-D-[Dpr, Orn or Lys](B)--R.sup.3(Y)--NR.sup.4R.sup.5; or R.sup.1(X)-D-[Dpr, Orn or Lys](A)-R.sup.2(Z)-D-[Dpr, Orn or Lys](B)--R.sup.3(Y)--NR.sup.4R.sup.5, in which X is a hard acid cat
7138103 Use of bi-specific antibodies for pre-targeting diagnosis and therapy November 21, 2006
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recog
7011816 Labeling targeting agents with gallium-68 and gallium-67 March 14, 2006
A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable agent. The labeling method and compositions disclosed ensure that a simple elution of galli










 
 
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