| Patent Number |
Title Of Patent |
Date Issued |
| 7553830 |
Compositions for the delivery of negatively charged molecules |
June 30, 2009 |
| This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex |
| 7109165 |
Conjugates and compositions for cellular delivery |
September 19, 2006 |
| This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules. |
| 6849726 |
Non-nucleotide containing RNA |
February 1, 2005 |
| The present invention relates to RNA molecules containing one or more non-nucleotide mimetics. |
| 6797815 |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
September 28, 2004 |
| Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides. |
| 6673611 |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
January 6, 2004 |
| This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using |
| 6617438 |
Oligoribonucleotides with enzymatic activity |
September 9, 2003 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to |
| 6586238 |
Enzymatic nucleic acids containing 5'-and or 3'-cap structures |
July 1, 2003 |
| An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide. |
| 6555668 |
Non-nucleotide containing enzymatic nucleic acid |
April 29, 2003 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 6528640 |
Synthetic ribonucleic acids with RNAse activity |
March 4, 2003 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to |
| 6509460 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
January 21, 2003 |
| Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed. |
| 6489465 |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
December 3, 2002 |
| Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides. |
| 6482932 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
November 19, 2002 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. |
| 6395713 |
Compositions for the delivery of negatively charged molecules |
May 28, 2002 |
| This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers. |
| 6379954 |
Amido and peptido modified catalytic oligonucleotides |
April 30, 2002 |
| Oligonucleotide comprising a nucleotide base having the formula: ##STR1##wherein B is a nucleotide base or hydrogen; R.sub.1, R.sub.2 and R.sub.3 independently is selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, an amine, |
| 6362323 |
Non-nucleotide containing nucleic acid |
March 26, 2002 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 6316612 |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
November 13, 2001 |
| Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides. |
| 6268534 |
Process for the synthesis of N,N-Dioleyl-N,N-Dimethylammonium Chloride |
July 31, 2001 |
| A novel process for the synthesis of N,N-dioleyl-N,N-dimethylammonium chloride (DODAC) is described. |
| 6248878 |
Nucleoside analogs |
June 19, 2001 |
| Novel nucleoside analogs, such as 3-(.beta.-D-Ribofuranosyl)-2-fluoropyridine, 3-(.beta.-D-Ribofuranosyl)-pyridin-2-one, 3-(.beta.-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one, 3-(.alpha.-D-Ribofuranosyl)-2-fluoropyridine, 5-(.beta.-D-Ribofuranosyl)-2-bromopyridine, 5- |
| 6127535 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
October 3, 2000 |
| Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed. |
| 6117657 |
Non-nucleotide containing enzymatic nucleic acid |
September 12, 2000 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 6093555 |
Amido and peptido modified enzymatic nucleic acid molecules |
July 25, 2000 |
| Oligonucleotide comprising a nucleotide base having the formula: ##STR1## wherein B is a nucleotide base or hydrogen; R.sub.1, R.sub.2 and R.sub.3 independently is selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, an am |
| 5998203 |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
December 7, 1999 |
| An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide. |
| 5891683 |
Non-nucleotide containing enzymatic nucleic acid |
April 6, 1999 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 5783425 |
Amino and peptido modified enzymatic nucleic acid |
July 21, 1998 |
| An enzymatic nucleic acid molecule, comprising a moiety having the formula: ##STR1## wherein B is a nucleotide base or hydrogen; R is selected from the group consisting of aminoacyl group, and NHR.sub.4 group, wherein said R.sub.4 is independently selected from the group consisting o |
| 5672501 |
Base-modified enzymatic nucleic acid |
September 30, 1997 |
| An enzymatic nucleic acid having a modification selected from pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, 6-methyl-uracil and aminophenyl. |
| 5506349 |
Chemical synthesis of 2', 3'-dideoxycytidine |
April 9, 1996 |
| Method for synthesis of 2',3'-dideoxycytidine by providing 5'-silylated-2',3'-dideoxyuridine as an intermediate. |
