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Inventor: Matter; Hans
Address: Langenselbold, DE
No. of patents: 23
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 7507734 |
Pyridazinone derivatives |
March 24, 2009 |
| Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R.sup.1 and R.sup.2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharma |
| 7470689 |
4-benzimidazol-2-ylpyridazin-3-one derivatives |
December 30, 2008 |
| Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R.sup.1 and R.sup.2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals |
| 7465806 |
Pyrrole-derivatives as factor Xa inhibitors |
December 16, 2008 |
| The present invention relates to compounds of the formulae I and Ia, ##STR00001## wherein R.sup.0; R.sup.1; R3; R4; R22, Q; V, G and M have the meanings indicated in the claims. The compounds of the formulae I and Ia are valuable pharmacologically active compounds. They exhibit a strong |
| 7462613 |
Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
December 9, 2008 |
| The present invention relates to novel pyridazinone derivatives of the general formula (I) ##STR00001## wherein A is A1 or A2; ##STR00002## R is unsubstituted or at least monosubstituted C.sub.1-C.sub.10-alkyl, aryl, aryl-(C.sub.1-C.sub.10-alkyl)-, heteroaryl, heteroaryl-(C.sub.1-C |
| 7435747 |
Guanidine and amidine derivatives as factor Xa inhibitors |
October 14, 2008 |
| The present invention relates to compounds of the formula I, ##STR00001## in which R.sub.0; Q; X; Q', D, R.sub.10 and V have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effe |
| 7429581 |
Pyrazole-derivatives as factor Xa inhibitors |
September 30, 2008 |
| The present invention is directed to a compound of formula I, ##STR00001## in which R.sup.0; R.sup.1; R.sup.2; R.sup.3; R.sup.4; Q; V, G and M have the meanings indicated below. The compound of formula I is a pharmacologically active compound. It exhibits a strong anti-thrombotic ef |
| 7399770 |
Thieno-imino acid derivatives for use as matrix metalloproteinase inhibitors |
July 15, 2008 |
| The invention is directed to a compound of the formula I ##STR00001## wherein the variables are as defined herein, or a stereoisomeric form thereof, mixture of stereoisomeric forms, in any ratio, or a salt thereof.Another aspect of the present invention is directed to a pharmaceutica |
| 7365088 |
Indazole-derivatives as factor Xa inhibitors |
April 29, 2008 |
| The present invention relates to a compound of the formula I ##STR00001## wherein J.sub.1, J.sub.2, R.sup.0, R.sup.1, R.sup.2, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic eff |
| 7358268 |
Imidazole derivatives as factor Xa inhibitors |
April 15, 2008 |
| This invention is directed to the compound of formula (I) which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as in inhibiting the formation of thrombi |
| 7317027 |
Azaindole-derivatives as factor Xa inhibitors |
January 8, 2008 |
| The present invention relates to compounds of the formula I ##STR00001## wherein R.sup.0, R.sup.1, R.sup.2, R.sup.3, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are |
| 7309701 |
Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
December 18, 2007 |
| The present invention relates to novel pyridazinone derivatives of the general formula (I) ##STR00001## wherein A is A1 or A2; ##STR00002## R is unsubstituted or at least monosubstituted C.sub.1-C.sub.10-alkyl, aryl, aryl-(C.sub.1-C.sub.10-alkyl)-, heteroaryl, heteroaryl-(C.s |
| 7205315 |
Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases |
April 17, 2007 |
| The present invention is directed to a compound of formula (I), or a stereoisomer or a mixture of stereoisomer thereof in any ratio, or its physiologically tolerable salt, which is useful as an inhibitor of matrix metalloproteinase. The present invention is also directed to a pharmac |
| 7153876 |
Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and t |
December 26, 2006 |
| Compounds of formula I, ##STR00001## in which R.sup.1, R.sup.2, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, for treating thromboembolic diseases |
| 7067665 |
Oxybenzamide derivatives useful for inhibiting factor Xa or Vlla |
June 27, 2006 |
| The present invention relates to compounds comprising the following formula: R.sup.0-Q-X-Q'-W-U-V-G-M (I) These compounds are useful as pharmacologically active compounds. They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiov |
| 6953857 |
Oxybenzamide derivatives useful for inhibiting factor Xa or viia |
October 11, 2005 |
| The present invention relates to compounds comprising the following formula:These compounds are useful as pharmacologically active compounds. They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders such as thromboem |
| 6906084 |
Indole derivatives as factor Xa inhibitors |
June 14, 2005 |
| The present invention relates to compounds of formula I, ##STR1##in which R.sup.0 ; R.sup.1 ; R.sup.2 ; R.sup.3 ; R.sup.4 ; R.sup.5 ; R.sup.6 ; R.sup.7 ; Q; V, G and M have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compound |
| 6759420 |
Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical composit |
July 6, 2004 |
| The present invention is directed to new compounds for the inhibition of blood clotting proteins and factor Xa activity, and more particularly, to arylalkanoyl derivatives of the formula (I): ##STR1##wherein R(1), R(2), R(3), R(4), R(5), R(6a), and R(6b) have the meanings indicated i |
| 6743790 |
Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
June 1, 2004 |
| The present invention relates to compounds of the formula I, ##STR1##in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A, X, m and n have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a stro |
| 6706715 |
Urea derivatives with antiproteolytic activity |
March 16, 2004 |
| The present invention relates to compounds of the formula I, ##STR1##in which R.sup.1, R.sup.2, R.sup.4, R.sup.5, D.sub.1, D.sub.2, X.sub.1, X.sub.2, X.sub.3, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compo |
| 6645992 |
Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and t |
November 11, 2003 |
| Compounds of formula I, ##STR1##in which R.sup.1, R.sup.2, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, for treating thromboembolic diseases and re |
| 6500803 |
Factor VIIa inhibitors |
December 31, 2002 |
| The present invention relates to compounds of formula I, ##STR1##in which R.sup.1, R.sup.2, R.sup.91, R.sup.92, R.sup.93, R.sup.94, R.sup.95, R.sup.96, R.sup.97, r, s, and t have the meanings indicated in the claims. Compounds of formula I are valuable pharmacologically active compou |
| 6395737 |
Malonic acid derivatives, processes for their preparation, for their use and pharmaceutical comp |
May 28, 2002 |
| New compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula I, ##STR1##wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated in the claims. The compounds of formula I are inhibitors of the blood c |
| 6337344 |
Indole derivatives as inhibitors or factor Xa |
January 8, 2002 |
| The present invention relates to the inhibition of blood clotting proteins, and more particularly, to indole derivatives of formula (I), in which R.sup.1a, R.sup.1b, R.sup.1c R.sup.1d, R.sup.2, R.sup.3, R.sup.4 and A are defined as indicated in the claims. The compounds of formula (I) ar |
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