| Patent Number |
Title Of Patent |
Date Issued |
| 4423068 |
(3.2.0) Bicycloheptanone oxime ethers with therapeutic properties |
December 27, 1983 |
| Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) ##STR1## as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein:n is an integer from one to four;R.sub.1 is hydroxy;R.sub.2 is hydrogen; orR.sub. |
| 4323564 |
Esters of 6-chloro-11.beta., 17.alpha.,21-trihydroxypregna-1,4,6-triene-3,20-dione |
April 6, 1982 |
| The 17-butyrate, 17-benzoate, 17,21-methyl orthobutyrate, 17,21-methyl orthobenzoate, and 17,21-dibutyrate esters of cloprednol (6-chloro-11.beta., 17.alpha., 21-trihydroxy-pregna-1,4,6-triene-3,20-dione) are useful as topical, anti-inflammatory steroids. |
| 4322421 |
4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives |
March 30, 1982 |
| Certain 1,4,5,6-tetrahydropyrimidine compounds which are substituted with an amino, amido or carbamate at the 2-position, with an optionally substituted phenyl at the 5-position or at the 4-position when there is no alkyl at the 1-position and optionally a lower alkyl at the 1-position |
| 4261995 |
4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives |
April 14, 1981 |
| Certain 1,4,5,6-tetrahydropyrimidine compounds which are substituted with an amino, amido or carbamate at the 2-position, with an optionally substituted phenyl at the 5-position or at the 4-position when there is no alkyl at the 1-position and optionally a lower alkyl at the 1-position |
| 4181720 |
Corticosteroid antiinflammatory agents |
January 1, 1980 |
| 22-Optionally substituted steroids of the corticoid series are prepared from the corresponding 21-methylene steroids through the 20,21-dione steroid intermediates. These compounds have utility as anti-inflammatory agents. |
| 4087438 |
Thieno[3,4-d]furoxan and process for its preparation |
May 2, 1978 |
| The racemic mixtures dl-6-(4-carbo lower alkoxybutyl)-4H-6H-thieno[3,4-d]furoxan are novel. The dl mixtures are prepared by reacting the lower alkyl ester of dl-7-thia-6-nitromethyl-9-nitrononenoic acid with phosphorus oxychloride and a tertiary amine catalyst. |
| 4065452 |
21,21-Dihalo steroids |
December 27, 1977 |
| Novel, topically-active anti-inflammatory steroids are represented by the formula ##STR1## wherein X is fluoro, chloro or hydrogen; X.sup.1 is fluoro, chloro, bromo, or hydrogen; X.sup.2 is hydroxy or may be chloro when X.sup.1 is chloro; and X.sup.3 and X.sup.4 are independently |
| 4064240 |
21-Cyclic acetals of steroidal 21-aldehydes and methods of preparation |
December 20, 1977 |
| 21-Cyclic acetals of steroids of the corticoid series are prepared from the corresponding 21-hydroxy steroids. The products have utility as anti-inflammatory agents. |
| 4044020 |
Process for preparing biotin |
August 23, 1977 |
| Biotin is prepared by (a) ozonizing methylcyclohexene; (b) reacting nitromethane with the methyl-6-oxohexanoate from a to form 7-nitro-6 hydroxyheptanoic acid methyl ester; (c) acylating to form the corresponding 6 acyloxy compound; (d) forming a double bond at the 6 position; (e) re |
| 4038409 |
1-Phenethylimidazoles |
July 26, 1977 |
| Novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole ring by an optionally substituted hydrocarbyl ester, thioester, or dithioester are useful as antimicrobial agents and as intermediates in the preparation of novel 1-phenethylimidazoles substituted at the posi |
| 4036974 |
1-{2'-[R'-Thio(oxy)]-3'-(R.sup.2 -thio(oxy)]propyl}imidazoles |
July 19, 1977 |
| Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl or the group ##STR2## IN WHICH N IS 0 TO 3; X and Y are independently oxygen or sulfur; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprot |
| 4036973 |
Imidazol-1-yl propane derivatives |
July 19, 1977 |
| Compounds of the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is alkyl or the group ##STR2## IN WHICH N IS 0 TO 3 AND THE OTHER OF R.sup.1 and R.sup.2 is benzyl, substituted benzyl, phenyl or substituted phenyl, said substituted benzyl and substituted phenyl substitute |
| 4036970 |
Imidazol-1-yl propane derivatives |
July 19, 1977 |
| Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently benzyl substituted benzyl, phenyl or substituted phenyl, said substituted benzyl and substituted phenyl substituted on the phenyl ring with one or more substituents independently selected from the gro |
| 4011315 |
21-Acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation |
March 8, 1977 |
| 21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES ARE PREPARED FROM THE CORRESPONDING 21-HYDROXY STEROIDS AND HAVE UTILITY AS ANTI-INFLAMMATORY AGENTS. |
| 3996358 |
21-Esters of steroidal-21-aldehyde hydrates and 21-aldehyde hemiacetals and methods of preparati |
December 7, 1976 |
| 21-Esters of 21-aldehyde hydrates and 21-aldehyde hemiacetals of steroids of the corticoid series are prepared from the corresponding 21-hydroxy steroids and have utility as antiinflammatory agents. |
| 3966825 |
Process for preparing .beta.-nitroethanethiol |
June 29, 1976 |
| .beta.-Nitroethanethiol is prepared by reacting a carboxylic acid ester of .beta.-nitroethananol with trisodium thiophosphate and hydrolyzing the reasulting thiophosphate ester to form .beta.-nitroethanethiol. |
| 3965181 |
Tricyclic pharmacological agents, intermediates and methods of making |
June 22, 1976 |
| 5-(3-Substituted prop-cis-1-enyl)- and 5-(3-substituted prop-trans-1-enyl)- derivatives of 5H-dibenzo[a,d]cycloheptenes and 10,11-dihydro-5H-dibenzo[a,d]cycloheptenes and methods of making. The process of preparing the 5-(3-substituted prop-cis-1-enyl)- derivatives comprises hydrogen |
