| Patent Number |
Title Of Patent |
Date Issued |
| 7326794 |
Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
February 5, 2008 |
| The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroind- ol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I' thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the prepa |
| 7279595 |
Process for the preparation of high purity perindopril |
October 9, 2007 |
| The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroind- ol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I' thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the prepa |
| 5726201 |
Gemfibrozil containing pharmaceutical compositions |
March 10, 1998 |
| The invention relates to oral solid pharmaceutical composition containing as active ingredient gemfibrozil and conventional pharmaceutical auxiliary agents comprising as surfactant bis-(2-ethyl-hexyl)-sodium-sulfosuccinate in an amount of 0.05-0.5% by weight relative to gemfibrozil conte |
| 5545741 |
Process for the preparation of epibatidine |
August 13, 1996 |
| The invention relates to a process for the preparation of racemic or optically active epibatidine of the Formula XIV ##STR1## which comprises subjecting racemic or optically active epi-epibatidine-of the Formula XIII ##STR2## to epimerization in the presence base. The advanta |
| 5543155 |
Diffusion-osmotic controlled drug-release pharmaceutical composition and process for preparing s |
August 6, 1996 |
| The invention relates to a novel diffusion-osmotic controlled drug-release pharmaceutical composition containing a one-layer tablet core including a polymeric film-coat, a therapeutically active agent and a hydrophilic polymer; if desired, a two-layer tablet core including active agent a |
| 5473072 |
Process for the preparation of high purity buspiron and the hydrochloride thereof |
December 5, 1995 |
| Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-d ione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-y |
| 5216157 |
1,4,Dihydro-pyridine intermediates |
June 1, 1993 |
| The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, the |
| 5126457 |
Process for the preparation of 1,4-dihydro-pyridine derivatives |
June 30, 1992 |
| The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene meth |
| 5108757 |
Solid pharmaceutical composition and a process for preparing same |
April 28, 1992 |
| The present invention relates to a process for the preparation of regulated release solid pharmaceutical compositions comprising 4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyridin e (referred to further on as "nifedipine") as active ingredient which comprises a |
| 5047230 |
Aerosol composition comprising nitroglycerin as active ingredient |
September 10, 1991 |
| The present invention relates to an aerosol composition free of propellant gas, comprising nitroglycerin as active ingredient. The composition according to the invention is composed of:0.1 to 4% by weight of nitroglycerin,51 to 90% by weight of a C.sub.2-4 aliphatic alcohol (component A),10 |
| 4921960 |
Quinoline thioethers |
May 1, 1990 |
| The new compounds of the general Formula I ##STR1## (wherein R.sub.1 stands for C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.2-5 alkinyl, C.sub.3-7 cycloalkyl or optionally substituted phenyl-(C.sub.1-4 alkyl);R.sub.2 represents hydrogen or C.sub.1-5 alkanoyl;X.sub.1 and X.sub.2 can be |
| 4921861 |
Pharmaceutical compositions |
May 1, 1990 |
| The 3-amino-4-ethylthio-quinoline of the Formula I ##STR1## and pharmaceutically acceptable acid addition salts thereof possess useful therapeutical properties. They exhibit a potent and highly selective anxiolytic and narcosis potentiating effect and are devoid of sedative and a |
| 4921854 |
Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds |
May 1, 1990 |
| The compounds of the general formula I ##STR1## and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy.In the general Formula IA stands for --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 -- |
| 4904669 |
Thiazolo/4,5-c/quinolines as major tranquilizers |
February 27, 1990 |
| The invention relates to new thiazolo[4,5-c]quinoline derivatives of the general Formula I ##STR1## and acid addition salts thereof, a process for the preparation of the same and pharmaceutical compositions comprising the said compounds.The substituent definition of the general Formu |
| 4883798 |
Pharmaceutical compositions |
November 28, 1989 |
| The compounds of the general Formula I ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different and each stands for hydrogen, hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy-C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy or phenyl-(C.sub.1-3 alkoxy), or R.sup.1 and R.sup.2 together |
| 4873249 |
Pharmaceutical composition |
October 10, 1989 |
| The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.The pharmaceutical compositions of the present |
| 4778811 |
Pharmaceutical compositions of 2-methyl-thiazolo[4,5-c]quinoline |
October 18, 1988 |
| It has been found that 2-methyl-thiazolo[4,5-c]quinoline and pharmaceutically acceptable acid addition salts and hydrates thereof possess valuable central nervous depressive properties being different from those of benzodiazepines. The invention relates to pharmaceutical compositions |
| 4680315 |
Powder mixture having high propylene glycol content and process for the preparation thereof |
July 14, 1987 |
| The invention refers to a powder mixture having a high propylene glycol content and a process for the preparation thereof. The powder mixture consists of 25 to 75 percent by weight of propylene glycol and 75 to 25 percent by weight of magnesium oxide and/or magnesium peroxide and/or |
| 4618623 |
Carbazic acid derivatives, process for their preparation and compositions containing the same |
October 21, 1986 |
| The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same. The new compounds according to the invention correspond to the formula (I)wherein R.sup.1 stands for a C.sub. |
| 4587261 |
Cycloalkane derivatives and fodder compositions containing the same |
May 6, 1986 |
| The invention relates to new cycloalkane derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same.The new compounds of the present invention correspond to the general formula I ##STR1## wherein n is 3, |
| 4570002 |
Carbazic acid derivatives |
February 11, 1986 |
| The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same.The new compounds according to the invention correspond to the formula (I)whereinR.sup.1 stands for a C.sub.7-12 c |
| 4461769 |
Nitrogen bridgehead compounds having anti-allergic effect |
July 24, 1984 |
| Compounds of the formula I ##STR1## or pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers or tautomeric forms thereof are disclosedwhereinR is hydrogen or lower alkylR.sup.1 is hydrogen, lower alkyl, styryl, or a carboxylic acid; |
| 4260612 |
Antiallergic nitrogen bridge-head compounds |
April 7, 1981 |
| Antiallergic and antiasthmatic compounds of the formula ##STR1## of which 9-phenylamino-6-methyl-4-oxo-6,7-dihydro-4H-pyrido(1,2-a)pyrimidine-3-carb oxylic acid and optically active antipodes and salts thereof are examples. |
| 4234586 |
Nitrogen bridgehead compounds having anti-allergic effect |
November 18, 1980 |
| Antiallergic and particularly antiasthmatic compounds of the formula: ##STR1## of which 9-phenylhydrazono-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimi dine-3-carboxylic acid is an especially significant example. |
| 4228160 |
Inclusion complex of cyclodextrin and indomethacin and a process for the preparation thereof, me |
October 14, 1980 |
| The invention relates to an inclusion complex of 1-(p-chloro-benzoyl)-5-methoxy-2-methyl-indol-3-yl-acetic acid (indomethacin) and cyclodextrin of a molar ratio of about 2:1. The inclusion complex can be prepared by reacting about 2 moles of alpha or beta cyclodextrin with about 1 mo |
| 4027024 |
Pharmaceutical composition having synergistic analgesic activity |
May 31, 1977 |
| Pharmaceutical compositions of synergistic analgesic activity are provided which comprise an azido compound of the following formula: ##STR1## or a salt thereof wherein R is hydrogen, methyl, ethyl, acetyl or morpholino-methyl and a compound of the formula: ##STR2## wherein R |
| 3954986 |
Pharmaceutical composition having synergistic analgesic activity |
May 4, 1976 |
| An analgesic substitute for morphine comprising the synergistic combination of azidomorphine or azidocodeine with a pyrimidazolium. |
