| Patent Number |
Title Of Patent |
Date Issued |
| 7345153 |
Compounds capable of inhibiting HIV-1 infection |
March 18, 2008 |
| This invention provides an antibody capable of specifically inhibiting the fusion of an HIV-1 envelope glycoprotein.sup.+ cell with an appropriate CD4.sup.+ cell without cross reacting with the HIV-1 envelope glycoprotein or CD4 and capable of inhibiting infection by one or more stra |
| 7118859 |
Methods for inhibiting HIV-1 infection |
October 10, 2006 |
| This invention provides an antibody capable of specifically inhibiting the fusion of an HIV-1 envelope glycoprotein.sup.+ cell with an appropriate CD4.sup.+ cell without cross reacting with the HIV-1 envelope glycoprotein or CD4 and capable of inhibiting infection by one or more stra |
| 7070991 |
Cells expressing a CD4-IgG2 chimeric heterotetramer |
July 4, 2006 |
| This invention provides an expression vector encoding a CD4-gamma2 chimeric heavy chain homodimer. This invention also provides an expression vector encoding the heavy chains of a CD4-IgG2 chimeric heterotetramer. Finally, this invention provides an expression vector encoding the lig |
| 6737267 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates, and uses thereof |
May 18, 2004 |
| This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxi |
| 6673896 |
Derivatives of soluble T-4 |
January 6, 2004 |
| This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence sh |
| 6570000 |
DNA encoding the T cell surface protein CD4 and use of fragments of CD4 in the treatment of AIDS |
May 27, 2003 |
| A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject |
| 6451313 |
CD4-gamma2 and CD4-IGG2 chimeras |
September 17, 2002 |
| This invention provides an expression vector encoding a CD4-gamma2 chimeric heavy chain homodimer. This invention also provides an expression vector encoding the heavy chains of a CD4-IgG2 chimeric heterotetramer. Finally, this invention provides an expression vector encoding the light c |
| 6342586 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates and uses thereof |
January 29, 2002 |
| This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxi |
| 6187748 |
Uses of CD4-gamma2 and CD4-IgG2 chimeras |
February 13, 2001 |
| This invention provides the CD4-IgG2 chimeric heterotetramer, wherein the heavy chains of the chimeric heterotetramer is encoded by the expression vector designated CD4-IgG2HC-pRcCMV (ATCC No. 75193). This invention also provides the CD4-IgG2 chimeric heterotetramer, wherein the light ch |
| 6177549 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates, and uses thereof |
January 23, 2001 |
| This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxi |
| 6093539 |
DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS |
July 25, 2000 |
| This invention provides an isolated single-stranded nucleic acid which encodes an aqueous-soluble polypeptide comprising at least a portion of a human T4 glycoprotein, which portion specifically forms a complex with a human immunodeficiency virus envelope glycoprotein. |
| 6083478 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 Immunoconjugates, and uses thereof |
July 4, 2000 |
| An immunoconjugate which consists of a cytotoxic radionuclide and a homodimer comprising two heavy chains, the cytotoxic radionuclide being linked to the heavy chains dirctly or using a bifunctional chelator and a composition which comprises the immunoconjugate and an acceptable carrier. |
| 6034223 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates, and uses thereof |
March 7, 2000 |
| This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxi |
| 5958678 |
DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS |
September 28, 1999 |
| A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject |
| 5886163 |
HIV-1 antigens, antibody compositions related thereto, and therapeutic and prophylactic uses the |
March 23, 1999 |
| The subject invention provides a recombinant nucleic acid molecule which encodes a mutant HIV-1 gp120 envelope glycoprotein comprising a V3 loop deletion and a C4 domain.sub.(W.fwdarw.X) point mutation wherein X is an amino acid residue other than tryptophan, and the HIV-1 gp120 envelope |
| 5871913 |
DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS |
February 16, 1999 |
| A single-stranded nucleic acid molecule which encodes the amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject |
| 5869624 |
HIV-1 vaccines, antibody compositions related thereto, and therapeutic and prophylactic uses the |
February 9, 1999 |
| The subject invention provides a recombinant nucleic acid molecule which encodes a mutant HIV-1 gp120 envelope glycoprotein comprising a V3 loop deletion and a C4 domain.sub.(W.fwdarw.X) point mutation wherein X is an amino acid residue other than tryptophan, and the HIV-1 gp120 envelope |
| 5817767 |
Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same |
October 6, 1998 |
| The invention is directed to compositions containing CD4-based immunoconjugates and antibodies specific for the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1). The CD4-based immunoconjugates comprise a portion obtained from CD4 conjugated to a heavy or light cha |
| 5422274 |
Internal deletion mutants of soluble T4(CD4) |
June 6, 1995 |
| This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in |
| 5126433 |
Soluble forms of the T cell surface protein CD4 |
June 30, 1992 |
| A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject |
| 5110906 |
Derivatives of soluble T-4 |
May 5, 1992 |
| This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence sh |
