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Inventor:
Lou; Yan
Address:
San Jose, CA
No. of patents:
10
Patents:












Patent Number Title Of Patent Date Issued
8119636 Pyrrolopyrazine kinase inhibitors February 21, 2012
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, ##STR00001## wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
8008298 Pyrrolopyrazine kinase inhibitors August 30, 2011
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, ##STR00001## wherein the variables Q.sup.1, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
7943618 Btk protein kinase inhibitors May 17, 2011
This application discloses pyridine and pyrimidine compounds according to formula I wherein R.sup.1, ##STR00001## R.sup.2, R.sup.3, R.sup.4, R.sup.5, X.sup.1 and A are as described herein which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and
7939531 Pyrrolopyrazine kinase inhibitors May 10, 2011
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, ##STR00001## wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
7932254 Pyrrolopyrazine kinase inhibitors April 26, 2011
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, ##STR00001## wherein the variables Q.sup.1 and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
7906509 Inhibitors of bruton's tyrosine kinase March 15, 2011
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-III: ##STR00001## wherein, variables R, X, Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, n and m are defined as described herein, which inhibit Btk. The compounds d
7902197 Pyrrolopyrazine kinase inhibitors March 8, 2011
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, ##STR00001## wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
7902194 Inhibitors of bruton's tyrosine kinase March 8, 2011
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-IV: ##STR00001## wherein, variables R, X, Y.sup.1, Y.sup.2, Y.sup.2, Y.sup.3, Y.sup.4, n and m are defined as described herein, which inhibit Btk. The com
7683064 Inhibitors of Bruton's tyrosine kinase March 23, 2010
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-III: ##STR00001## wherein, variables R, X, Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, n and m are defined as described herein, which inhibit Btk. The compounds d
7563800 Substituted pyrazolo[3,4-D]pyrimidines as p38 map kinase inhibitors July 21, 2009
Compounds of formula Ia or Ib: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.










 
 
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