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Inventor: Losel; Walter
Address: Gau-Algesheim, DE
No. of patents: 28
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 6465483 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
October 15, 2002 |
| A compound of formula I ##STR1##wherein A denotes a benzo, indolo or thieno group; R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of |
| 6180645 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
January 30, 2001 |
| A compound of formula I ##STR1##whereinA denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2##whereinR.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substitue |
| 6136819 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
October 24, 2000 |
| Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1 -.sub.6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4 -.sub.7)cycloalkyl, (C.sub.4 - |
| 6034094 |
Pharmaceutically useful 3,4-dihydroisoquinoline |
March 7, 2000 |
| The invention relates to the use of carbocyclically and heterocycally fused dihydroyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhabiting blood clotting, and also relates to new compounds of formula Ie ##STR1## |
| 5968948 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
October 19, 1999 |
| Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl( |
| 5925650 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
July 20, 1999 |
| A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of |
| 5861412 |
Dihydro-isoquinoline compounds and their use as pharmaceuticals |
January 19, 1999 |
| Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing t |
| 5837712 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
November 17, 1998 |
| A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of t |
| 5783576 |
Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositi |
July 21, 1998 |
| New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions. |
| 5688793 |
Pyridazino[4',5':3,4]pyrrolo-[2,1-a]-isoquinolines and the use thereof for preparing pharmaceuti |
November 18, 1997 |
| The invention relates to new pyridazino[4',5':3,4]-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids and complex-forming agents, wherein X is O, S or NHO and R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub. |
| 5686462 |
Anti-inflammatory method |
November 11, 1997 |
| The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1## |
| 5677304 |
9-amino-pyridazino[4'5':3,4]pyrrolo-[2,1-a]isoquinolines and the use thereof for the production |
October 14, 1997 |
| The invention relates to the use of 9-amino-pyridazino-[4',5':3,4]pyrrolo[2,1-a]isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcerat |
| 5674878 |
Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations |
October 7, 1997 |
| Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing t |
| 5665729 |
Cerebroprojection method |
September 9, 1997 |
| The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1## |
| 5661157 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
August 26, 1997 |
| Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --0--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl( |
| 5643919 |
Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation |
July 1, 1997 |
| Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing t |
| 5614516 |
12-aminopyridazinopyrroloisoquinoline compounds |
March 25, 1997 |
| The invention relates to new 12-amino-pyridazino-[4',5':3,4]-pyrrolo[2,1-a]isoquinolines of general formula (I) ##STR1## wherein --NR.sub.1 R.sub.2 represents an amino or substituted amino group, and acid addition salts thereof. The new active substances have potential use in |
| 5607943 |
Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations |
March 4, 1997 |
| A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## whereinR.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the |
| 5565452 |
9-amino-pyridazino[4',5':3,4]pyrrolo-[2,1-A]isoquinolines and the use thereof for the production |
October 15, 1996 |
| The invention relates to the use of 9-amino-pyridazino-[4', 5':3,4]pyrrolo[2,1-a]isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcera |
| 5008273 |
Amino acid derivatives and their pharmaceutical use |
April 16, 1991 |
| Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way. |
| 4826855 |
Thieno pyridines and their use as anti-hypertensive agents |
May 2, 1989 |
| Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms, or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m a |
| 4766217 |
Preparation of 5,6-dihydro-pyrrolo[2,1-a]isoquinolines |
August 23, 1988 |
| 5,6,-dihydro-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## are prepared by heating a 1-(3-furyl)-3,4-dihydro-isoquinoline of the formula ##STR2## in a primary or secondary amine to at least 80.degree. C. for several hours, the amine is removed, the reaction product is t |
| 4766129 |
Pyrrolo[2,3-C]pyridines and their use as anti-hypertensive agents |
August 23, 1988 |
| Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m ar |
| 4694085 |
5,6-dihydro-pyrrolo[2,1-a]isoquinolines and the preparation thereof |
September 15, 1987 |
| The invention relates to 5,6-dihydro-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## wherein R, R.sup.2, R.sup.3, and R.sup.7, which may be identical or different, each represent a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms;R.sup.1 represents a cyano, hyd |
| 4683238 |
2,3,4,9-tetrahydro beta carboline derivatives, useful as antihypertensive agents |
July 28, 1987 |
| Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m ar |
| 4555511 |
Thieno [3,2,C]pyridines useful as antihypertensives |
November 26, 1985 |
| Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms; and the |
| 4452789 |
1-Furyl-3,4-dihydro-isoquinolines |
June 5, 1984 |
| Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydroxyl or lower alkoxyR.sub.3 is cyano or --CO--Y;Y is hydroxyl, lower alkoxy, or a primary or secondary, substituted or unsubstituted, aliphatic, cycloal |
| 4322418 |
Substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines, compositions and use |
March 30, 1982 |
| This invention relates to substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines in the racemic or optically active form and the non-toxic pharmacologically acceptable salts thereof. These compounds are useful in the promotion of blood circulation in warm-blooded anim |
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