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Inventor:
Losel; Walter
Address:
Gau-Algesheim, DE
No. of patents:
28
Patents:












Patent Number Title Of Patent Date Issued
6465483 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations October 15, 2002
A compound of formula I ##STR1##wherein A denotes a benzo, indolo or thieno group; R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of
6180645 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations January 30, 2001
A compound of formula I ##STR1##whereinA denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2##whereinR.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substitue
6136819 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations October 24, 2000
Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1 -.sub.6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4 -.sub.7)cycloalkyl, (C.sub.4 -
6034094 Pharmaceutically useful 3,4-dihydroisoquinoline March 7, 2000
The invention relates to the use of carbocyclically and heterocycally fused dihydroyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhabiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
5968948 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations October 19, 1999
Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(
5925650 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations July 20, 1999
A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of
5861412 Dihydro-isoquinoline compounds and their use as pharmaceuticals January 19, 1999
Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing t
5837712 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations November 17, 1998
A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of t
5783576 Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositi July 21, 1998
New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
5688793 Pyridazino[4',5':3,4]pyrrolo-[2,1-a]-isoquinolines and the use thereof for preparing pharmaceuti November 18, 1997
The invention relates to new pyridazino[4',5':3,4]-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids and complex-forming agents, wherein X is O, S or NHO and R.sub.1, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.
5686462 Anti-inflammatory method November 11, 1997
The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
5677304 9-amino-pyridazino[4'5':3,4]pyrrolo-[2,1-a]isoquinolines and the use thereof for the production October 14, 1997
The invention relates to the use of 9-amino-pyridazino-[4',5':3,4]pyrrolo[2,1-a]isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcerat
5674878 Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations October 7, 1997
Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing t
5665729 Cerebroprojection method September 9, 1997
The invention relates to the use of carbocyclically and heterocyclically fused dihydropyridines as cerebroprotective agents, as agents for treating chronic inflammatory processes and as agents for inhibiting blood clotting, and also relates to new compounds of formula Ie ##STR1##
5661157 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations August 26, 1997
Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --0--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1-6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4-7)cycloalkyl, (C.sub.4-6)cycloalkyl(
5643919 Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation July 1, 1997
Compound of general formula I ##STR1## wherein A is a benzo or thieno group;R.sub.1 is (C.sub.4-6)cycloalkyl, (C.sub.4-6)cycloalkyl-(C.sub.1-5)alkyl or ##STR2## R.sup.2, m, R.sup.3, R.sup.4, R and u are defined as in the specification, and pharmaceutical preparations containing t
5614516 12-aminopyridazinopyrroloisoquinoline compounds March 25, 1997
The invention relates to new 12-amino-pyridazino-[4',5':3,4]-pyrrolo[2,1-a]isoquinolines of general formula (I) ##STR1## wherein --NR.sub.1 R.sub.2 represents an amino or substituted amino group, and acid addition salts thereof. The new active substances have potential use in
5607943 Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations March 4, 1997
A compound of formula I ##STR1## wherein A denotes a benzo, indolo or thieno group;R.sup.1 denotes thienyl or the group ##STR2## whereinR.sup.7, R.sup.8 and R.sup.9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, whilst not more than 2 of the
5565452 9-amino-pyridazino[4',5':3,4]pyrrolo-[2,1-A]isoquinolines and the use thereof for the production October 15, 1996
The invention relates to the use of 9-amino-pyridazino-[4', 5':3,4]pyrrolo[2,1-a]isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and complexing agents for preparing agents for treating chronic inflammatory processes, ulcera
5008273 Amino acid derivatives and their pharmaceutical use April 16, 1991
Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
4826855 Thieno pyridines and their use as anti-hypertensive agents May 2, 1989
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms, or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m a
4766217 Preparation of 5,6-dihydro-pyrrolo[2,1-a]isoquinolines August 23, 1988
5,6,-dihydro-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## are prepared by heating a 1-(3-furyl)-3,4-dihydro-isoquinoline of the formula ##STR2## in a primary or secondary amine to at least 80.degree. C. for several hours, the amine is removed, the reaction product is t
4766129 Pyrrolo[2,3-C]pyridines and their use as anti-hypertensive agents August 23, 1988
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m ar
4694085 5,6-dihydro-pyrrolo[2,1-a]isoquinolines and the preparation thereof September 15, 1987
The invention relates to 5,6-dihydro-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## wherein R, R.sup.2, R.sup.3, and R.sup.7, which may be identical or different, each represent a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms;R.sup.1 represents a cyano, hyd
4683238 2,3,4,9-tetrahydro beta carboline derivatives, useful as antihypertensive agents July 28, 1987
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl(alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms;n and m ar
4555511 Thieno [3,2,C]pyridines useful as antihypertensives November 26, 1985
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms; and the
4452789 1-Furyl-3,4-dihydro-isoquinolines June 5, 1984
Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydroxyl or lower alkoxyR.sub.3 is cyano or --CO--Y;Y is hydroxyl, lower alkoxy, or a primary or secondary, substituted or unsubstituted, aliphatic, cycloal
4322418 Substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines, compositions and use March 30, 1982
This invention relates to substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines in the racemic or optically active form and the non-toxic pharmacologically acceptable salts thereof. These compounds are useful in the promotion of blood circulation in warm-blooded anim










 
 
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